Structure-activity relationship studies of a novel series of anthrax lethal factor inhibitors (Q42811116)

7 November 2017

Structure-activity relationship studies of a novel series of anthrax lethal factor inhibitors (English)

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7 November 2017

Sherida L Johnson

1

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7 November 2017

Li-Hsing Chen

2

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7 November 2017

Elisa Barile

3

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7 November 2017

Aras Emdadi

4

1 reference

7 November 2017

Mojgan Sabet

5

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7 November 2017

Hongbin Yuan

6

1 reference

7 November 2017

Jun Wei

7

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7 November 2017

Donald Guiney

8

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7 November 2017

Maurizio Pellecchia

9

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7 November 2017

language of work or name

English

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publication date

26 March 2009

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Bioorganic & Medicinal Chemistry

7 November 2017

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7 November 2017

17

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7 November 2017

9

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7 November 2017

3352-3368

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Combating the threat of anthrax: a quantitative structure-activity relationship approach

7 November 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730741

Discovery of aminoquinolines as a new class of potent inhibitors of heat shock protein 90 (Hsp90): Synthesis, biology, and molecular modeling

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730741

Low molecular weight inhibitors of the protease anthrax lethal factor

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730741

Anthrax edema toxin sensitizes DBA/2J mice to lethal toxin

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730741

A high-throughput screening approach to anthrax lethal factor inhibition

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730741

Anthrax lethal factor protease inhibitors: synthesis, SAR, and structure-based 3D QSAR studies.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730741

Bacillus anthracis edema toxin causes extensive tissue lesions and rapid lethality in mice

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730741

Metalloproteinase inhibitors, nonantimicrobial chemically modified tetracyclines, and ilomastat block Bacillus anthracis lethal factor activity in viable cells

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730741

Receptor-specific requirements for anthrax toxin delivery into cells

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730741

Efficient synthetic inhibitors of anthrax lethal factor

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730741

Anthrax lethal factor inhibition

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730741

Structure-based design, synthesis, and study of potent inhibitors of beta-ketoacyl-acyl carrier protein synthase III as potential antimicrobial agents

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730741

Chemical screening by mass spectrometry to identify inhibitors of anthrax lethal factor

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730741

Identification of small molecule inhibitors of anthrax lethal factor

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730741

The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730741

Observations on experimental anthrax; demonstration of a specific lethal factor produced in vivo by Bacillus anthracis

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730741

Anthrax toxins and the host: a story of intimacy

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730741

Macrophage apoptosis by anthrax lethal factor through p38 MAP kinase inhibition

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730741

Screening inhibitors of anthrax lethal factor

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730741

A peptide-based fluorescence resonance energy transfer assay for Bacillus anthracis lethal factor protease

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730741

Design and therapeutic application of matrix metalloproteinase inhibitors

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730741

Empirical scoring functions: I. The development of a fast empirical scoring function to estimate the binding affinity of ligands in receptor complexes.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730741

Development and validation of a genetic algorithm for flexible docking

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730741

Rhodanine derivatives as selective protease inhibitors against bacterial toxins

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730741

Guanidinylated 2,5-dideoxystreptamine derivatives as anthrax lethal factor inhibitors

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730741

Inhibition of the proteolytic activity of anthrax lethal factor by aminoglycosides

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730741

Selectively guanidinylated derivatives of neamine. Syntheses and inhibition of anthrax lethal factor protease

16 August 2018

1 reference

12 December 2020

Novel small-molecule inhibitors of anthrax lethal factor identified by high-throughput screening

1 reference

12 December 2020

Identification of novel anthrax lethal factor inhibitors generated by combinatorial Pictet-Spengler reaction followed by screening in situ

1 reference

12 December 2020

Mechanistic differences between in vitro assays for hydrazone-based small molecule inhibitors of anthrax lethal factor

1 reference

12 December 2020

10.1016/J.BMC.2009.03.040

Identifiers

DOI

1 reference

7 November 2017

1 reference

7 November 2017

PubMed publication ID

19359184

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