Oncogenic Ras-mediated downregulation of Gadd153/CHOP is required for Ras-induced cellular transformation (Q42815082)

7 November 2017

title

Oncogenic Ras-mediated downregulation of Gadd153/CHOP is required for Ras-induced cellular transformation (English)

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7 November 2017

Rong Rong

1

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7 November 2017

JoAnne Montalbano

2

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7 November 2017

Weixin Jin

3

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7 November 2017

Jennifer Zhang

4

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7 November 2017

Maria Garling

5

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7 November 2017

M Saeed Sheikh

6

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7 November 2017

Ying Huang

7

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7 November 2017

language of work or name

English

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publication date

1 July 2005

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7 November 2017

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7 November 2017

volume

24

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7 November 2017

issue

30

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7 November 2017

page(s)

4867-4872

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1208660

7 November 2017

exact match

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cites work

CHOP (GADD153) and its oncogenic variant, TLS-CHOP, have opposing effects on the induction of G1/S arrest.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208660

The downregulation of the pro-apoptotic protein Par-4 is critical for Ras-induced survival and tumor progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208660

A target for phosphoinositide 3-kinase: Akt/PKB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208660

Amino Acid Limitation Induces Expression ofCHOP, a CCAAT/Enhancer Binding Protein-related Gene, at Both Transcriptional and Post-transcriptional Levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208660

Increasing complexity of Ras signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208660

The phosphoinositide 3-kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208660

A human oncogene of the RAS superfamily unmasked by expression cDNA cloning

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208660

The dark side of Ras: regulation of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208660

Cellular survival: a play in three Akts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208660

The product of par-4, a gene induced during apoptosis, interacts selectively with the atypical isoforms of protein kinase C

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208660

Ras signalling and apoptosis

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1208660

Targeting RAS signalling pathways in cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208660

hsp70-DnaJ chaperone pair prevents nitric oxide- and CHOP-induced apoptosis by inhibiting translocation of Bax to mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208660

Aberrant function of the Ras-related protein TC21/R-Ras2 triggers malignant transformation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208660

Reduction of trans-4,5-dihydroxy-1,2-dithiane by cellular oxidoreductases activates gadd153/chop and grp78 transcription and induces cellular tolerance in kidney epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208660

Endoplasmic reticulum calcium pool depletion-induced apoptosis is coupled with activation of the death receptor 5 pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208660

Akt signaling: linking membrane events to life and death decisions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208660

Inhibition of CHOP translation by a peptide encoded by an open reading frame localized in the chop 5'UTR

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208660

GADD153-mediated anticancer effects of N-(4-hydroxyphenyl)retinamide on human hepatoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208660

Function and regulation of ras.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1208660

How do small GTPase signal transduction pathways regulate cell cycle entry?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208660

Ectopic expression of CHOP (GADD153) induces apoptosis in M1 myeloblastic leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208660

Stress-inducible transcription factor CHOP/gadd153 induces apoptosis in mammalian cells via p38 kinase-dependent and -independent mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208660

Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208660

Involvement of phosphatidylinositol 3-kinase, but not RalGDS, in TC21/R-Ras2-mediated transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208660

Oncogenic Ras sensitizes cells to apoptosis by Par-4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208660

Isolation, characterization and chromosomal localization of the human GADD153 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208660

Negative regulation of Par-4 by oncogenic Ras is essential for cellular transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208660

CCAAT/enhancer-binding proteins: structure, function and regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208660

CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208660

TC21 mediates transformation and cell survival via activation of phosphatidylinositol 3-kinase/Akt and NF-kappaB signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208660

Activation of the Raf/MAP kinase cascade by the Ras-related protein TC21 is required for the TC21-mediated transformation of NIH 3T3 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208660

Activation of the Ral and phosphatidylinositol 3' kinase signaling pathways by the ras-related protein TC21.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208660

Downregulation of the pro-apoptotic protein Bak is required for the ras-induced transformation of intestinal epithelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208660

Upregulation of BiP and CHOP by the unfolded-protein response is independent of presenilin expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208660

PKB/AKT: functional insights from genetic models

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208660

Expression and function of the leucine zipper protein Par-4 in apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208660

Akt/PKB activity is required for Ha-Ras-mediated transformation of intestinal epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208660

CHOP/GADD153 and methionyl-tRNA synthetase (MetRS) genes overlap in a conserved region that controls mRNA stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208660

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208660

Signals from the stressed endoplasmic reticulum induce C/EBP-homologous protein (CHOP/GADD153).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208660

21 January 2018

Identifiers

DOI

10.1038/SJ.ONC.1208660

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Dimensions Publication ID

7 November 2017

1017026678

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