Role of mTOR in the degradation of IRS-1: regulation of PP2A activity (Q42816608)

7 November 2017

Role of mTOR in the degradation of IRS-1: regulation of PP2A activity (English)

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7 November 2017

David Hartley

1

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PubMed ID

11948686

7 November 2017

Geoffrey M Cooper

series ordinal

2

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7 November 2017

1 January 2002

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Journal of Cellular Biochemistry

7 November 2017

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7 November 2017

85

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7 November 2017

2

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7 November 2017

304-314

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Alpha 4 associates with protein phosphatases 2A, 4, and 6

7 November 2017

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Release of insulin receptor substrate proteins from an intracellular complex coincides with the development of insulin resistance.

21 January 2018

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Novel protein serine/threonine phosphatases: variety is the spice of life

21 January 2018

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Nutrients, via the Tor proteins, stimulate the association of Tap42 with type 2A phosphatases

21 January 2018

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Membrane-targeted phosphatidylinositol 3-kinase mimics insulin actions and induces a state of cellular insulin resistance

21 January 2018

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Regulation of translation initiation by FRAP/mTOR

21 January 2018

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A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1.

21 January 2018

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A role for protein kinase Bbeta/Akt2 in insulin-stimulated GLUT4 translocation in adipocytes

21 January 2018

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Dynamics of insulin signaling in 3T3-L1 adipocytes. Differential compartmentalization and trafficking of insulin receptor substrate (IRS)-1 and IRS-2.

21 January 2018

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Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling

21 January 2018

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Tor proteins and protein phosphatase 2A reciprocally regulate Tap42 in controlling cell growth in yeast

21 January 2018

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Differential regulation of insulin receptor substrates-1 and -2 (IRS-1 and IRS-2) and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse

21 January 2018

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Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2.

21 January 2018

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Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation

21 January 2018

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Modulation of insulin receptor substrate-1 tyrosine phosphorylation by an Akt/phosphatidylinositol 3-kinase pathway

21 January 2018

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Phosphorylation and microtubule association of the Opitz syndrome protein mid-1 is regulated by protein phosphatase 2A via binding to the regulatory subunit alpha 4.

21 January 2018

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Regulation of protein kinase cascades by protein phosphatase 2A.

21 January 2018

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B cell receptor-associated protein alpha4 displays rapamycin-sensitive binding directly to the catalytic subunit of protein phosphatase 2A

21 January 2018

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Compartment-specific regulation of phosphoinositide 3-kinase by platelet-derived growth factor and insulin in 3T3-L1 adipocytes

21 January 2018

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A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1.

21 January 2018

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A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphory

21 January 2018

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Protein phosphatase 2A interacts with the 70-kDa S6 kinase and is activated by inhibition of FKBP12-rapamycinassociated protein

21 January 2018

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Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway

21 January 2018

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Differentiated 3T3L1 adipocytes are composed of heterogenous cell populations with distinct receptor tyrosine kinase signaling properties.

21 January 2018

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Platelet-derived growth factor inhibits insulin stimulation of insulin receptor substrate-1-associated phosphatidylinositol 3-kinase in 3T3-L1 adipocytes without affecting glucose transport

21 January 2018

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Mammalian target of rapamycin pathway regulates insulin signaling via subcellular redistribution of insulin receptor substrate 1 and integrates nutritional signals and metabolic signals of insulin

21 January 2018

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The insulin signalling system and the IRS proteins

21 January 2018

1 reference

The insulin receptor: structure and function

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1002/JCB.10135

1 reference

7 November 2017

1 reference

PubMed ID

11948686