Skp2 regulates the antiproliferative function of the tumor suppressor RASSF1A via ubiquitin-mediated degradation at the G1-S transition (Q42819481)

8 November 2017

Skp2 regulates the antiproliferative function of the tumor suppressor RASSF1A via ubiquitin-mediated degradation at the G1-S transition (English)

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8 November 2017

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Song MS

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8 November 2017

Song SJ

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8 November 2017

Kim SJ

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8 November 2017

Nakayama K

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Nakayama KI

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8 November 2017

language of work or name

English

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publication date

10 December 2007

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8 November 2017

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3176-3185

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1210971

8 November 2017

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cites work

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Gene amplification and overexpression of CDK4 in sporadic breast carcinomas is associated with high tumor cell proliferation

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The tumor suppressor RASSF1A and MAP-1 link death receptor signaling to Bax conformational change and cell death

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Aberrant ubiquitin-mediated proteolysis of cell cycle regulatory proteins and oncogenesis

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Control of the SCF(Skp2-Cks1) ubiquitin ligase by the APC/C(Cdh1) ubiquitin ligase

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The SCF ubiquitin ligase: insights into a molecular machine

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SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

21 January 2018

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Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3.

21 January 2018

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Identification of the E1A-regulated transcription factor p120 E4F as an interacting partner of the RASSF1A candidate tumor suppressor gene

21 January 2018

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Skp2 is oncogenic and overexpressed in human cancers

21 January 2018

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A phosphorylation-driven ubiquitination switch for cell-cycle control

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Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation

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Role of the F-box protein Skp2 in lymphomagenesis

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ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

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Interaction between ubiquitin-protein ligase SCFSKP2 and E2F-1 underlies the regulation of E2F-1 degradation

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RASSF1A elicits apoptosis through an MST2 pathway directing proapoptotic transcription by the p73 tumor suppressor protein

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Cyclin-dependent kinases regulate the antiproliferative function of Smads

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Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication

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Skp2-mediated degradation of p27 regulates progression into mitosis

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Role of the tumor suppressor RASSF1A in Mst1-mediated apoptosis.

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When protein destruction runs amok, malignancy is on the loose

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Ratchets and clocks: the cell cycle, ubiquitylation and protein turnover

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Tumor suppressor RASSF1A is a microtubule-binding protein that stabilizes microtubules and induces G2/M arrest

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CDK inhibitors: positive and negative regulators of G1-phase progression

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The RASSF1A tumor suppressor blocks cell cycle progression and inhibits cyclin D1 accumulation

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The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex

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The RASSF1A isoform of RASSF1 promotes microtubule stability and suppresses tumorigenesis

21 January 2018

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A role for the RASSF1A tumor suppressor in the regulation of tubulin polymerization and genomic stability

21 January 2018

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Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex

21 January 2018

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A novel target gene, SKP2, within the 5p13 amplicon that is frequently detected in small cell lung cancers.

21 January 2018

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Whose end is destruction: cell division and the anaphase-promoting complex

21 January 2018

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Mitotic kinase Aurora-A phosphorylates RASSF1A and modulates RASSF1A-mediated microtubule interaction and M-phase cell cycle regulation

21 January 2018

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7 January 2021

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Identifiers

DOI

10.1038/SJ.ONC.1210971

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Dimensions Publication ID

8 November 2017

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1 reference