Human fibroblast replicative senescence can occur in the absence of extensive cell division and short telomeres (Q42827551)

8 November 2017

Human fibroblast replicative senescence can occur in the absence of extensive cell division and short telomeres (English)

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8 November 2017

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Munro J

1

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8 November 2017

Steeghs K

2

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8 November 2017

Morrison V

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8 November 2017

Ireland H

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8 November 2017

Parkinson EK

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8 November 2017

language of work or name

English

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publication date

1 June 2001

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8 November 2017

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8 November 2017

20

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8 November 2017

27

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8 November 2017

3541-3552

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1204460

8 November 2017

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cites work

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Telomere length predicts replicative capacity of human fibroblasts

21 January 2018

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Telomere shortening is associated with cell division in vitro and in vivo

21 January 2018

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Extension of life-span by introduction of telomerase into normal human cells

21 January 2018

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Gene mutations and increased levels of p53 protein in human squamous cell carcinomas and their cell lines

21 January 2018

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Replicative senescence of human fibroblast-like cells in culture

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A biomarker that identifies senescent human cells in culture and in aging skin in vivo

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Accumulation of the cyclin-dependent kinase inhibitor p27/Kip1 and the timing of oligodendrocyte differentiation

21 January 2018

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p27Kip1 alters the response of cells to mitogen and is part of a cell-intrinsic timer that arrests the cell cycle and initiates differentiation.

21 January 2018

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Senescence of cultured human fibroblasts: mitotic versus metabolic time.

21 January 2018

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Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence

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Telomere loss: mitotic clock or genetic time bomb?

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THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS

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21 January 2018

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Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype

21 January 2018

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Evidence for a telomere-independent "clock" limiting RAS oncogene-driven proliferation of human thyroid epithelial cells

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p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2

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Hypervariable ultra-long telomeres in mice

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Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells.

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Essential role of mouse telomerase in highly proliferative organs

21 January 2018

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Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening

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Expression of p24, a novel p21Waf1/Cip1/Sdi1-related protein, correlates with measurement of the finite proliferative potential of rodent embryo fibroblasts

21 January 2018

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Absence of cancer-associated changes in human fibroblasts immortalized with telomerase

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A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon

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p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest

21 January 2018

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Agents that cause DNA double strand breaks lead to p16INK4a enrichment and the premature senescence of normal fibroblasts

21 January 2018

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Role of the INK4a locus in tumor suppression and cell mortality.

21 January 2018

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Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

21 January 2018

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Clonal heterogeneity in fibroblast phenotype: implications for the control of epithelial-mesenchymal interactions

21 January 2018

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Microarray analysis of replicative senescence

21 January 2018

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Accelerated telomere shortening in fibroblasts after extended periods of confluency.

21 January 2018

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TRF2 Protects Human Telomeres from End-to-End Fusions

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Origins of G1 arrest in senescent human fibroblasts

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The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

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Ras activity late in G1 phase required for p27kip1 downregulation, passage through the restriction point, and entry into S phase in growth factor-stimulated NIH 3T3 fibroblasts

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ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase.

21 January 2018

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Expression of the p16INK4a tumor suppressor versus other INK4 family members during mouse development and aging.

21 January 2018

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Inhibition of the Phosphoinositide 3-Kinase Pathway Induces a Senescence-like Arrest Mediated by p27Kip1

21 January 2018

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p19ARF links the tumour suppressor p53 to Ras

21 January 2018

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Translocation of cdk2 to the nucleus during G1-phase in PDGF-stimulated human fibroblasts

21 January 2018

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7 January 2021

Inhibitors of cyclin-dependent kinases induce features of replicative senescence in early passage human diploid fibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204460

7 January 2021

Stochastic mechanism of cellular aging--abrupt telomere shortening as a model for stochastic nature of cellular aging

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7 January 2021

Intraclonal variation in proliferative potential of human diploid fibroblasts: stochastic mechanism for cellular aging

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7 January 2021

Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span

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7 January 2021

Differential CDK-inhibitor gene expression in aging human diploid fibroblasts

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204460

7 January 2021

Mild Hyperoxia Shortens Telomeres and Inhibits Proliferation of Fibroblasts: A Model for Senescence?

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7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1204460

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Dimensions Publication ID

8 November 2017

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