Insulin antagonizes interleukin-6 signaling and is anti-inflammatory in 3T3-L1 adipocytes (Q42831454)

8 November 2017

Insulin antagonizes interleukin-6 signaling and is anti-inflammatory in 3T3-L1 adipocytes (English)

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8 November 2017

Christian X Andersson

1

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8 November 2017

Victoria Rotter Sopasakis

2

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8 November 2017

Emelie Wallerstedt

3

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8 November 2017

Ulf Smith

4

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8 November 2017

language of work or name

English

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publication date

31 January 2007

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Journal of Biological Chemistry

8 November 2017

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8 November 2017

282

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8 November 2017

13

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8 November 2017

9430-9435

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The effect of PPARgamma ligands on the adipose tissue in insulin resistance

8 November 2017

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https://api.crossref.org/works/10.1074%2FJBC.M609980200

High local concentrations and effects on differentiation implicate interleukin-6 as a paracrine regulator.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609980200

Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-alpha, in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609980200

Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-alpha, overexpressed in human fat cells from insulin-resistant subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609980200

A family of cytokine-inducible inhibitors of signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609980200

Suppressor of cytokine signaling 3 is a physiological regulator of adipocyte insulin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609980200

SOCS-3 is an insulin-induced negative regulator of insulin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609980200

Severely impaired adipsin expression in genetic and acquired obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609980200

Principles of interleukin (IL)-6-type cytokine signalling and its regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609980200

The YXXQ motif in gp 130 is crucial for STAT3 phosphorylation at Ser727 through an H7-sensitive kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609980200

Sequential activation of Rac-1, SEK-1/MKK-4, and protein kinase Cdelta is required for interleukin-6-induced STAT3 Ser-727 phosphorylation and transactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609980200

Requirement for Ras/Rac1-mediated p38 and c-Jun N-terminal kinase signaling in Stat3 transcriptional activity induced by the Src oncoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609980200

Rapid inhibition of interleukin-6 signaling and Stat3 activation mediated by mitogen-activated protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609980200

Serine phosphorylation and negative regulation of Stat3 by JNK

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609980200

Protein kinase C delta associates with and phosphorylates Stat3 in an interleukin-6-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609980200

STAT3 serine phosphorylation by ERK-dependent and -independent pathways negatively modulates its tyrosine phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609980200

Mapping of Stat3 serine phosphorylation to a single residue (727) and evidence that serine phosphorylation has no influence on DNA binding of Stat1 and Stat3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609980200

STAT3 is a serine kinase target in T lymphocytes. Interleukin 2 and T cell antigen receptor signals converge upon serine 727.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609980200

Insulin inhibits intranuclear nuclear factor kappaB and stimulates IkappaB in mononuclear cells in obese subjects: evidence for an anti-inflammatory effect?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609980200

Design of conditionally active STATs: insights into STAT activation and gene regulatory function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609980200

Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609980200

Interleukin 6, the third mediator of acute-phase reaction, modulates hepatic protein synthesis in human and mouse. Comparison with interleukin 1 beta and tumor necrosis factor-alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609980200

Regulation of haptoglobin gene expression in 3T3-L1 adipocytes by cytokines, catecholamines, and PPARgamma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609980200

Abnormal mesoderm patterning in mouse embryos mutant for the SH2 tyrosine phosphatase Shp-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609980200

Serine phosphorylation and maximal activation of STAT3 during CNTF signaling is mediated by the rapamycin target mTOR

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609980200

Involvement of tyrosine phosphatase PTP1D in the inhibition of interleukin-6-induced Stat3 signaling by alpha-thrombin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609980200

A discoidin domain receptor 1/SHP-2 signaling complex inhibits alpha2beta1-integrin-mediated signal transducers and activators of transcription 1/3 activation and cell migration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609980200

Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609980200

SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609980200

The inhibition of interleukin-6-dependent STAT activation by mitogen-activated protein kinases depends on tyrosine 759 in the cytoplasmic tail of glycoprotein 130.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609980200

SHP-2 is a dual-specificity phosphatase involved in Stat1 dephosphorylation at both tyrosine and serine residues in nuclei

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609980200

Insulin stimulates the serine phosphorylation of the signal transducer and activator of transcription (STAT3) isoform

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609980200

ERK and PI3K negatively regulate STAT-transcriptional activities in human melanoma cells: implications towards sensitization to apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609980200

Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609980200

Fat apoptosis through targeted activation of caspase 8: a new mouse model of inducible and reversible lipoatrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609980200

Insulin signaling and action in fat cells: associations with insulin resistance and type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609980200

Insulin receptor substrate (IRS) 1 is reduced and IRS-2 is the main docking protein for phosphatidylinositol 3-kinase in adipocytes from subjects with non-insulin-dependent diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609980200

21 January 2018

Identifiers

DOI

10.1074/JBC.M609980200

1 reference

8 November 2017

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