Hijacking of the human alkyl-N-purine-DNA glycosylase by 3,N4-ethenocytosine, a lipid peroxidation-induced DNA adduct (Q42831683)

8 November 2017

Hijacking of the human alkyl-N-purine-DNA glycosylase by 3,N4-ethenocytosine, a lipid peroxidation-induced DNA adduct (English)

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8 November 2017

Laurent Gros

1

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8 November 2017

Andrei V Maksimenko

2

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8 November 2017

Cyril V Privezentzev

3

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8 November 2017

Jacques Laval

4

1 reference

8 November 2017

Murat K Saparbaev

5

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8 November 2017

language of work or name

English

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publication date

2 February 2004

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Journal of Biological Chemistry

8 November 2017

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8 November 2017

279

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8 November 2017

17

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8 November 2017

17723-17730

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Lipid peroxidation as a potential endogenous source for the formation of exocyclic DNA adducts.

8 November 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314010200

Characterization of 2'-deoxycytidine adducts derived from 4-oxo-2-nonenal, a novel lipid peroxidation product

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314010200

Endogenous DNA adducts: potential and paradox

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314010200

Increased low-density lipoprotein oxidation and impaired high-density lipoprotein antioxidant defense are associated with increased macrophage homing and atherosclerosis in dyslipidemic obese mice: LCAT gene transfer decreases atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314010200

Mutagenic and genotoxic effects of three vinyl chloride-induced DNA lesions: 1,N6-ethenoadenine, 3,N4-ethenocytosine, and 4-amino-5-(imidazol-2-yl)imidazole.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314010200

Mutagenic potency of exocyclic DNA adducts: marked differences between Escherichia coli and simian kidney cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314010200

1,N6-ethenodeoxyadenosine, a DNA adduct highly mutagenic in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314010200

3,N4-ethenocytosine, a highly mutagenic adduct, is a primary substrate for Escherichia coli double-stranded uracil-DNA glycosylase and human mismatch-specific thymine-DNA glycosylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314010200

A 55-kDa protein isolated from human cells shows DNA glycosylase activity toward 3,N4-ethenocytosine and the G/T mismatch

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314010200

Investigation of the substrate spectrum of the human mismatch-specific DNA N-glycosylase MED1 (MBD4): fundamental role of the catalytic domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314010200

hUNG2 is the major repair enzyme for removal of uracil from U:A matches, U:G mismatches, and U in single-stranded DNA, with hSMUG1 as a broad specificity backup

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314010200

Enzymology of the repair of free radicals-induced DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314010200

Cloning and characterization of a mouse 3-methyladenine/7-methyl-guanine/3-methylguanine DNA glycosylase cDNA whose gene maps to chromosome 11

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314010200

Base excision repair deficient mice lacking the Aag alkyladenine DNA glycosylase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314010200

Alkylpurine-DNA-N-glycosylase knockout mice show increased susceptibility to induction of mutations by methyl methanesulfonate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314010200

Increased susceptibility to streptozotocin-induced beta-cell apoptosis and delayed autoimmune diabetes in alkylpurine-DNA-N-glycosylase-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314010200

Altered expression of the DNA repair protein, N-methylpurine-DNA glycosylase (MPG) in breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314010200

Structure of the human 3-methyladenine DNA glycosylase gene and localization close to the 16p telomere

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314010200

Evidence for the simultaneous expression of alternatively spliced alkylpurine N-glycosylase transcripts in human tissues and cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314010200

Human cDNA expressing a functional DNA glycosylase excising 3-methyladenine and 7-methylguanine

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314010200

Purification and characterization of human 3-methyladenine-DNA glycosylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314010200

1,N(2)-ethenoguanine, a mutagenic DNA adduct, is a primary substrate of Escherichia coli mismatch-specific uracil-DNA glycosylase and human alkylpurine-DNA-N-glycosylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314010200

Specific binding of a designed pyrrolidine abasic site analog to multiple DNA glycosylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314010200

Repair of 8-hydroxyguanine in DNA by mammalian N-methylpurine-DNA glycosylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314010200

Cisplatin adducts inhibit 1,N(6)-ethenoadenine repair by interacting with the human 3-methyladenine DNA glycosylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314010200

Molecular beacons: probes that fluoresce upon hybridization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314010200

Fluorescence Energy Transfer as a Spectroscopic Ruler

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314010200

Recognition of cisplatin adducts by cellular proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314010200

Structural features of trinucleotide repeats associated with DNA expansion

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314010200

Excision of hypoxanthine from DNA containing dIMP residues by the Escherichia coli, yeast, rat, and human alkylpurine DNA glycosylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314010200

Induction of O6-methylguanine-DNA-methyltransferase and N3-methyladenine-DNA-glycosylase in human cells exposed to DNA-damaging agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314010200

Characterisation of new substrate specificities of Escherichia coli and Saccharomyces cerevisiae AP endonucleases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314010200

Heterogeneous repair of N-methylpurines at the nucleotide level in normal human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314010200

Escherichia coli, Saccharomyces cerevisiae, rat and human 3-methyladenine DNA glycosylases repair 1,N6-ethenoadenine when present in DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314010200

Substrate specificity of human methylpurine DNA N-glycosylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314010200

Chimeric RNA-DNA molecular beacon assay for ribonuclease H activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314010200

Targeted deletion of alkylpurine-DNA-N-glycosylase in mice eliminates repair of 1,N6-ethenoadenine and hypoxanthine but not of 3,N4-ethenocytosine or 8-oxoguanine

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314010200

Base incorporation and extension at a site-specific ethenocytosine by Escherichia coli DNA polymerase I Klenow fragment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314010200

Structural insights by molecular dynamics simulations into differential repair efficiency for ethano-A versus etheno-A adducts by the human alkylpurine-DNA N-glycosylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314010200

Ultrasensitive and specific detection methods for exocylic DNA adducts: markers for lipid peroxidation and oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314010200

Enzymology of repair of etheno-adducts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314010200

Crystal structure of a human alkylbase-DNA repair enzyme complexed to DNA: mechanisms for nucleotide flipping and base excision

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314010200

Molecular basis for discriminating between normal and damaged bases by the human alkyladenine glycosylase, AAG

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314010200

Structural studies of human alkyladenine glycosylase and E. coli 3-methyladenine glycosylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314010200

Solution structure of a DNA duplex containing the exocyclic lesion 3,N4-etheno-2'-deoxycytidine opposite 2'-deoxyguanosine

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314010200

Solution structure of an 11-mer duplex containing the 3, N(4)-ethenocytosine adduct opposite 2'-deoxycytidine: implications for the recognition of exocyclic lesions by DNA glycosylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314010200

Base excision and DNA binding activities of human alkyladenine DNA glycosylase are sensitive to the base paired with a lesion

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314010200

Two human homologs of Rad23 are functionally interchangeable in complex formation and stimulation of XPC repair activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314010200

3-Methyladenine-DNA glycosylase (MPG protein) interacts with human RAD23 proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314010200

Msh2 deficiency prevents in vivo somatic instability of the CAG repeat in Huntington disease transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314010200

Trinucleotide expansion in haploid germ cells by gap repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314010200

Mechanisms of resistance to cisplatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314010200

Exocyclic DNA adducts as oxidative stress markers in colon carcinogenesis: potential role of lipid peroxidation, dietary fat and antioxidants

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314010200

The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314010200

1,N6-ethenodeoxyadenosine and 3,N4-ethenodeoxycytine in liver DNA from humans and untreated rodents detected by immunoaffinity/32P-postlabeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314010200

Multicolor molecular beacons for allele discrimination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314010200

Potential role of lipid peroxidation derived DNA damage in human colon carcinogenesis: studies on exocyclic base adducts as stable oxidative stress markers

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314010200

The adaptive imbalance in base excision-repair enzymes generates microsatellite instability in chronic inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314010200

21 January 2018

Identifiers

DOI

10.1074/JBC.M314010200

1 reference

8 November 2017

1 reference