Characterizing the effects of saturated fatty acids on insulin signaling and ceramide and diacylglycerol accumulation in 3T3-L1 adipocytes and C2C12 myotubes (Q42834541)

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scientific article published on November 15, 2003

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English	Characterizing the effects of saturated fatty acids on insulin signaling and ceramide and diacylglycerol accumulation in 3T3-L1 adipocytes and C2C12 myotubes	scientific article published on November 15, 2003

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scholarly article

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Europe PubMed Central

8 November 2017

Characterizing the effects of saturated fatty acids on insulin signaling and ceramide and diacylglycerol accumulation in 3T3-L1 adipocytes and C2C12 myotubes (English)

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Europe PubMed Central

8 November 2017

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based on heuristic

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10.1016/J.ABB.2003.08.020

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Scott A Summers

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Scott A Summers

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Europe PubMed Central

8 November 2017

author name string

Jose Antonio Chavez

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Europe PubMed Central

8 November 2017

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publication date

1 November 2003

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Europe PubMed Central

8 November 2017

15 November 2003

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National Center for Biotechnology Information

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full work available at URL

https://api.elsevier.com/content/article/PII:S0003986103004648?httpAccept=text/xml

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10.1016/J.ABB.2003.08.020

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https://api.elsevier.com/content/article/PII:S0003986103004648?httpAccept=text/plain

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10.1016/J.ABB.2003.08.020

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Archives of Biochemistry and Biophysics

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8 November 2017

419

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101-109

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New perspectives into the molecular pathogenesis and treatment of type 2 diabetes

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The metabolic syndrome X.

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Signalling aspects of insulin resistance in skeletal muscle: mechanisms induced by lipid oversupply

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Banting lecture 2001: dysregulation of fatty acid metabolism in the etiology of type 2 diabetes

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Signaling pathways mediating insulin-stimulated glucose transport

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Insulin signaling in the adipocyte

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After insulin binds

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Insulin signalling: the role of insulin receptor substrate 1

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Insulin-stimulated GLUT4 translocation is relevant to the phosphorylation of IRS-1 and the activity of PI3-kinase

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Inhibition of phosphatidylinositol 3-kinase activity by adenovirus-mediated gene transfer and its effect on insulin action

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Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor

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Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt.

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Phosphatidylinositol 3-kinase

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Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation.

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PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond

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PI3K: downstream AKTion blocks apoptosis

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Regulation of insulin-stimulated glucose transporter GLUT4 translocation and Akt kinase activity by ceramide.

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Protein kinase C isoforms alpha, delta and theta require insulin receptor substrate-1 to inhibit the tyrosine kinase activity of the insulin receptor in human kidney embryonic cells (HEK 293 cells).

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Activation of protein kinase C alpha inhibits signaling by members of the insulin receptor family

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Protein kinase C modulates insulin action in human skeletal muscle

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Inhibition of insulin signaling and glycogen synthesis by phorbol dibutyrate in rat skeletal muscle

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Polyoma middle T antigen activates the Ser/Thr kinase Akt in a PI3-kinase-dependent manner

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The role of glycogen synthase kinase 3beta in insulin-stimulated glucose metabolism

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Characterization of free and glyceride-esterified long chain fatty acids in different skeletal muscle types of the rat

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Type of dietary fat and insulin resistance.

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Characterization of 3T3-L1 storage lipid metabolism: effect of somatotropin and insulin on specific pathways

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Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitate

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Quantitative determination of ceramide using diglyceride kinase

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Measurement of plasma glucose, free fatty acid, lactate, and insulin for 24 h in patients with NIDDM.

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Glucose and free fatty acid turnover in normal subjects and in diabetic patients before and after insulin treatment

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De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway

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Lipoapoptosis in beta-cells of obese prediabetic fa/fa rats. Role of serine palmitoyltransferase overexpression

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Diacylglycerol--when is it an intracellular messenger?

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10.1016/J.ABB.2003.08.020

1 reference

Europe PubMed Central

8 November 2017

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Europe PubMed Central

8 November 2017

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