Neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) slows down Alzheimer's disease-like pathology in amyloid precursor protein-transgenic mice (Q42870334)

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scientific article published on 18 May 2011

Language	Label	Description	Also known as
English	Neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) slows down Alzheimer's disease-like pathology in amyloid precursor protein-transgenic mice	scientific article published on 18 May 2011

Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

9 November 2017

Neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) slows down Alzheimer's disease-like pathology in amyloid precursor protein-transgenic mice (English)

1 reference

Europe PubMed Central

PMC publication ID

9 November 2017

Alzheimer's disease

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author name string

Dorothea Rat

1

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Europe PubMed Central

PMC publication ID

9 November 2017

Ulrich Schmitt

2

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Europe PubMed Central

PMC publication ID

9 November 2017

Frank Tippmann

3

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Europe PubMed Central

PMC publication ID

9 November 2017

Ilse Dewachter

4

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Europe PubMed Central

PMC publication ID

9 November 2017

Clara Theunis

5

1 reference

Europe PubMed Central

PMC publication ID

9 November 2017

Ewa Wieczerzak

6

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Europe PubMed Central

PMC publication ID

9 November 2017

Rolf Postina

7

1 reference

Europe PubMed Central

PMC publication ID

9 November 2017

Fred van Leuven

8

1 reference

Europe PubMed Central

PMC publication ID

9 November 2017

Falk Fahrenholz

9

1 reference

Europe PubMed Central

PMC publication ID

9 November 2017

Elzbieta Kojro

10

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9 November 2017

language of work or name

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publication date

18 May 2011

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Europe PubMed Central

PMC publication ID

9 November 2017

1 reference

Europe PubMed Central

PMC publication ID

9 November 2017

25

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Europe PubMed Central

PMC publication ID

9 November 2017

9

1 reference

Europe PubMed Central

PMC publication ID

9 November 2017

3208-3218

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Europe PubMed Central

PMC publication ID

9 November 2017

Retinoic acid receptor-α signalling antagonizes both intracellular and extracellular amyloid-β production and prevents neuronal cell death caused by amyloid-β.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3157688

27 May 2018

ADAM10 is the physiologically relevant, constitutive alpha-secretase of the amyloid precursor protein in primary neurons

1 reference

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SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10.

1 reference

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Statins and the squalene synthase inhibitor zaragozic acid stimulate the non-amyloidogenic pathway of amyloid-beta protein precursor processing by suppression of cholesterol synthesis

1 reference

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Pituitary adenylate cyclase-activating polypeptide and its receptors: 20 years after the discovery.

1 reference

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Detection of behavioral alterations and learning deficits in mice lacking synaptophysin.

1 reference

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Up-regulation of the alpha-secretase ADAM10 by retinoic acid receptors and acitretin

1 reference

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Role of PACAP and VIP in astroglial functions

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Pulmonary and systemic effects of inhaled PACAP38 in healthy male subjects

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Intravenous infusion of pituitary adenylate cyclase-activating polypeptide (PACAP) in a patient with multiple myeloma and myeloma kidney: a case study

1 reference

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Microarray analyses of pituitary adenylate cyclase activating polypeptide (PACAP)-regulated gene targets in sympathetic neurons

1 reference

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Oligomeric amyloid decreases basal levels of brain-derived neurotrophic factor (BDNF) mRNA via specific downregulation of BDNF transcripts IV and V in differentiated human neuroblastoma cells

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Pituitary adenylate cyclase-activating polypeptide (PACAP) decreases ischemic neuronal cell death in association with IL-6.

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Alzheimer's amyloid beta-peptide (1-42) induces cell death in human neuroblastoma via bax/bcl-2 ratio increase: an intriguing role for methionine 35.

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The neuropeptide PACAP promotes the alpha-secretase pathway for processing the Alzheimer amyloid precursor protein

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A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model

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Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide inhibit CBP-NF-kappaB interaction in activated microglia.

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The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

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Neuronal deficiency of presenilin 1 inhibits amyloid plaque formation and corrects hippocampal long-term potentiation but not a cognitive defect of amyloid precursor protein [V717I] transgenic mice.

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The neuroprotective effect of pituitary adenylate cyclase-activating polypeptide on cerebellar granule cells is mediated through inhibition of the CED3-related cysteine protease caspase-3/CPP32

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Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide inhibit nuclear factor-kappa B-dependent gene activation at multiple levels in the human monocytic cell line THP-1.

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Synergistic induction of pituitary adenylate cyclase-activating polypeptide (PACAP) gene expression by nerve growth factor and PACAP in PC12 cells

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VIP and PACAP potentiate the action of glutamate on BDNF expression in mouse cortical neurones

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Prevention of ischemia-induced death of hippocampal neurons by pituitary adenylate cyclase activating polypeptide

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Effects of pituitary adenylate cyclase-activating polypeptide (PACAP) on gonadotropin-releasing hormone and somatostatin gene expression in the rat brain

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Demonstration of specific binding sites for pituitary adenylate cyclase activating polypeptide (PACAP) in rat astrocytes

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Pituitary adenylate cyclase-activating polypeptide protects astroglial cells against oxidative stress-induced apoptosis

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Levels of alpha- and beta-secretase cleaved amyloid precursor protein in the cerebrospinal fluid of Alzheimer's disease patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/21593432

12 December 2020

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10.1096/FJ.10-180133

1 reference

Europe PubMed Central

PMC publication ID

9 November 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

9 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

9 November 2017

ResearchGate publication ID

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