LRRK2 G2019S mutation induces dendrite degeneration through mislocalization and phosphorylation of tau by recruiting autoactivated GSK3ß. (Q42873469)

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14 February 2020

title

LRRK2 G2019S mutation induces dendrite degeneration through mislocalization and phosphorylation of tau by recruiting autoactivated GSK3ß (English)

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14 February 2020

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1

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14 February 2020

Ruey-Meei Wu

series ordinal

3

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4

Cheng-Ting Chien

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14 February 2020

author name string

Pei-I Tsai

series ordinal

2

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14 February 2020

language of work or name

English

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publication date

1 September 2010

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14 February 2020

number of pages

12

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inferred from page(s)

published in

Journal of Neuroscience

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volume

30

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issue

39

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page(s)

13138-13149

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Phosphorylated serine422 on tau proteins is a pathological epitope found in several diseases with neurofibrillary degeneration

14 February 2020

cites work

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Synaptic localization and restricted diffusion of a Drosophila neuronal synaptobrevin--green fluorescent protein chimera in vivo.

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Tau protein isoforms, phosphorylation and role in neurodegenerative disorders11These authors contributed equally to this work

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Binding of the adenomatous polyposis coli protein to microtubules increases microtubule stability and is regulated by GSK3 beta phosphorylation

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Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus

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Glycogen Synthase Kinase-3 Modulates Neurite Outgrowth in Cultured Neurons: Possible Implications for Neurite Pathology in Alzheimer's Disease

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Involvement of aberrant glycosylation in phosphorylation of tau by cdk5 and GSK-3beta

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Functions and malfunctions of the tau proteins

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Different levels of the homeodomain protein cut regulate distinct dendrite branching patterns of Drosophila multidendritic neurons

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Lithium antagonizes dopamine-dependent behaviors mediated by an AKT/glycogen synthase kinase 3 signaling cascade

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Autosomal dominant parkinsonism associated with variable synuclein and tau pathology

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Refining GAL4-driven transgene expression in Drosophila with a GAL80 enhancer-trap.

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Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

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GSK-3beta regulates phosphorylation of CRMP-2 and neuronal polarity.

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Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

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GSK3B polymorphisms alter transcription and splicing in Parkinson's disease

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Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration

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LRRK2G2019S as a Cause of Parkinson's Disease in North African Arabs

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Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17)

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Parkinsonism, Lrrk2 G2019S, and tau neuropathology

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GSK3 at the edge: regulation of developmental specification and cell polarization

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The familial Parkinsonism gene LRRK2 regulates neurite process morphology

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A chaperone-dependent GSK3beta transitional intermediate mediates activation-loop autophosphorylation

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Lrrk2 G2385R is an ancestral risk factor for Parkinson's disease in Asia

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Cytoskeleton proteins are modulators of mutant tau-induced neurodegeneration in Drosophila.

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12 December 2020

LRK-1, a C. elegans PARK8-related kinase, regulates axonal-dendritic polarity of SV proteins

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Drosophila sensory neurons require Dscam for dendritic self-avoidance and proper dendritic field organization

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12 December 2020

Loss of LRRK2/PARK8 induces degeneration of dopaminergic neurons in Drosophila.

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12 December 2020

Mechanistic insight into the dominant mode of the Parkinson's disease-associated G2019S LRRK2 mutation

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12 December 2020

Calcium, ageing, and neuronal vulnerability in Parkinson's disease

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12 December 2020

Tau phosphorylation sites work in concert to promote neurotoxicity in vivo

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12 December 2020

Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells

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12 December 2020

The Roc domain of leucine-rich repeat kinase 2 is sufficient for interaction with microtubules

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The chaperone activity of heat shock protein 90 is critical for maintaining the stability of leucine-rich repeat kinase 2.

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Glycogen synthase kinase (GSK) 3beta directly phosphorylates Serine 212 in the regulatory loop and inhibits microtubule affinity-regulating kinase (MARK) 2.

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Phosphorylation of tau regulates its axonal transport by controlling its binding to kinesin.

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Sensory deficit in Parkinson's disease: evidence of a cutaneous denervation

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Drosophila models of neurodegenerative diseases

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The Parkinson disease protein leucine-rich repeat kinase 2 transduces death signals via Fas-associated protein with death domain and caspase-8 in a cellular model of neurodegeneration

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Parkinson's disease: from monogenic forms to genetic susceptibility factors

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Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease

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12 December 2020

Dopamine D1 receptor activation induces tau phosphorylation via cdk5 and GSK3 signaling pathways

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12 December 2020

Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis

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12 December 2020

Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's disease

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12 December 2020

Evidence for cdk5 as a Major Activity Phosphorylating Tau Protein in Porcine Brain Extract1

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12 December 2020

The extent of phosphorylation of fetal tau is comparable to that of PHF-tau from Alzheimer paired helical filaments

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12 December 2020

Phosphorylation of recombinant tau by cAMP-dependent protein kinase. Identification of phosphorylation sites and effect on microtubule assembly.

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12 December 2020

Neuropathology of Parkinson's disease

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12 December 2020

Phosphorylation of tau by glycogen synthase kinase-3β in intact mammalian cells: The effects on the organization and stability of microtubules

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Regulated phosphorylation and dephosphorylation of tau protein: effects on microtubule interaction, intracellular trafficking and neurodegeneration

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Unique Alzheimer's disease paired helical filament specific epitopes involve double phosphorylation at specific sites.

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12 December 2020

Sequential phosphorylation of Tau by glycogen synthase kinase-3beta and protein kinase A at Thr212 and Ser214 generates the Alzheimer-specific epitope of antibody AT100 and requires a paired-helical-filament-like conformation

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In vivo dynamics of axon pathfinding in the Drosophilia CNS: a time-lapse study of an identified motorneuron.

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12 December 2020

10.1523/JNEUROSCI.1737-10.2010

Identifiers

DOI

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14 February 2020

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14 February 2020

PubMed publication ID

20881132

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