Geldanamycin promotes premature mitotic entry and micronucleation in irradiated p53/p21 deficient colon carcinoma cells (Q42930980)

11 November 2017

Geldanamycin promotes premature mitotic entry and micronucleation in irradiated p53/p21 deficient colon carcinoma cells (English)

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11 November 2017

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D M Moran

1

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11 November 2017

G Gawlak

2

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11 November 2017

M S Jayaprakash

3

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11 November 2017

S Mayar

4

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11 November 2017

C G Maki

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11 November 2017

language of work or name

English

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publication date

26 May 2008

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11 November 2017

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11 November 2017

27

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11 November 2017

42

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11 November 2017

5567-5577

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https://scigraph.springernature.com/pub.10.1038/onc.2008.172

11 November 2017

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cites work

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Schedule-dependent synergy between the heat shock protein 90 inhibitor 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin and doxorubicin restores apoptosis to p53-mutant lymphoma cell lines

27 May 2018

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Inhibition of homologous recombination repair in irradiated tumor cells pretreated with Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin

27 May 2018

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P53-dependent radiosensitizing effects of Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin on human oral squamous cell carcinoma cell lines

27 May 2018

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Inhibition of hsp90 compromises the DNA damage response to radiation

27 May 2018

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The p53 tumor suppressor participates in multiple cell cycle checkpoints

27 May 2018

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HSP90 and the chaperoning of cancer

27 May 2018

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Regulation of p21(WAF1/CIP1) stability by WISp39, a Hsp90 binding TPR protein

27 May 2018

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Enhanced tumor cell radiosensitivity and abrogation of G2 and S phase arrest by the Hsp90 inhibitor 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin

27 May 2018

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Hsp90 activation and cell cycle regulation

27 May 2018

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Role of cell cycle in mediating sensitivity to radiotherapy

27 May 2018

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G2 checkpoint abrogators as anticancer drugs

27 May 2018

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Cell death by mitotic catastrophe: a molecular definition

27 May 2018

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Hsp90 inhibition depletes Chk1 and sensitizes tumor cells to replication stress

27 May 2018

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A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors

27 May 2018

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DNA damage checkpoint control in cells exposed to ionizing radiation

27 May 2018

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Non-targeted and Delayed Effects of Exposure to Ionizing Radiation: II. Radiation-Induced Genomic Instability and Bystander EffectsIn Vivo,Clastogenic Factors and Transgenerational Effects

27 May 2018

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Non-targeted and Delayed Effects of Exposure to Ionizing Radiation: I. Radiation-Induced Genomic Instability and Bystander EffectsIn Vitro

27 May 2018

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Therapeutic exploitation of checkpoint defects in cancer cells lacking p53 function

27 May 2018

1 reference

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If not apoptosis, then what? Treatment-induced senescence and mitotic catastrophe in tumor cells

27 May 2018

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Radiosensitization of p53 mutant cells by PD0166285, a novel G(2) checkpoint abrogator.

27 May 2018

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MDM2 can promote the ubiquitination, nuclear export, and degradation of p53 in the absence of direct binding

27 May 2018

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ATM phosphorylates histone H2AX in response to DNA double-strand breaks

27 May 2018

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An indolocarbazole inhibitor of human checkpoint kinase (Chk1) abrogates cell cycle arrest caused by DNA damage

27 May 2018

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How does radiation kill cells?

27 May 2018

1 reference

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Requirement for p53 and p21 to sustain G2 arrest after DNA damage

27 May 2018

1 reference

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Delayed chromosomal instability induced by DNA damage

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811229

G1 phase progression: cycling on cue

27 May 2018

1 reference

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Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811229

Regulatory phosphorylation of the p34cdc2 protein kinase in vertebrates

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811229

Colcemid and the mitotic cycle

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811229

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811229

Phase I pharmacokinetic and pharmacodynamic study of 17-allylamino, 17-demethoxygeldanamycin in patients with advanced malignancies

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811229

Phase I and pharmacologic study of 17-(allylamino)-17-demethoxygeldanamycin in adult patients with solid tumors.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811229

Knockdown of Chk1, Wee1 and Myt1 by RNA interference abrogates G2 checkpoint and induces apoptosis

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811229

Geldanamycin and 17-allylamino-17-demethoxygeldanamycin potentiate the in vitro and in vivo radiation response of cervical tumor cells via the heat shock protein 90-mediated intracellular signaling and cytotoxicity.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811229

Coadministration of the heat shock protein 90 antagonist 17-allylamino- 17-demethoxygeldanamycin with suberoylanilide hydroxamic acid or sodium butyrate synergistically induces apoptosis in human leukemia cells

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811229

Hsp90 chaperone complexes are required for the activity and stability of yeast protein kinases Mik1, Wee1 and Swe1.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811229

Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811229

Chromosomal instability and its relationship to other end points of genomic instability.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811229

Preferential radiosensitization of G1 checkpoint-deficient cells by methylxanthines.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811229

Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21

16 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FONC.2008.172

MDM2 binding induces a conformational change in p53 that is opposed by heat-shock protein 90 and precedes p53 proteasomal degradation

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FONC.2008.172

31 March 2020

Identifiers

DOI

10.1038/ONC.2008.172

1 reference

Dimensions Publication ID

11 November 2017

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11 November 2017

1 reference