DNA damage checkpoint control in cells exposed to ionizing radiation (Q35208818)

7 August 2017

title

DNA damage checkpoint control in cells exposed to ionizing radiation (English)

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7 August 2017

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George Iliakis

1

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7 August 2017

Ya Wang

series ordinal

2

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7 August 2017

Jun Guan

series ordinal

3

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7 August 2017

Huichen Wang

series ordinal

4

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7 August 2017

language of work or name

English

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publication date

1 September 2003

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7 August 2017

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7 August 2017

volume

22

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7 August 2017

issue

37

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7 August 2017

page(s)

5834-5847

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Involvement of the interaction between p21 and proliferating cell nuclear antigen for the maintenance of G2/M arrest after DNA damage.

7 August 2017

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CHK2 kinase--a busy messenger.

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DNA replication in eukaryotic cells

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Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro

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Effects of ionizing radiation on cell cycle progression

21 January 2018

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Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity

21 January 2018

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p38 and Chk1 kinases: different conductors for the G(2)/M checkpoint symphony

21 January 2018

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The G(2) DNA damage checkpoint delays expression of genes encoding mitotic regulators

21 January 2018

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DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme?

21 January 2018

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Initiation of DNA replication in eukaryotic cells

21 January 2018

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The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01

21 January 2018

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Identification of CDK4 as a target of c-MYC.

21 January 2018

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The role of p53 and pRB in apoptosis and cancer

21 January 2018

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Role of inhibitory CDC2 phosphorylation in radiation-induced G2 arrest in human cells

21 January 2018

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Nuclear localization of cyclin B1 controls mitotic entry after DNA damage

21 January 2018

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The checkpoint protein Chfr is a ligase that ubiquitinates Plk1 and inhibits Cdc2 at the G2 to M transition

21 January 2018

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The many substrates and functions of ATM

21 January 2018

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A p53-independent damage-sensing mechanism that functions as a checkpoint at the G1/S transition in Chinese hamster ovary cells

21 January 2018

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Purification and characterization of human DNA damage checkpoint Rad complexes

21 January 2018

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myc function and regulation

21 January 2018

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Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro

21 January 2018

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Kinetics of DNA Double-strand Break Repair Throughout the Cell Cycle as Assayed by Pulsed Field Gel Electrophoresis in CHO Cells

21 January 2018

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Animal cell cycles and their control

21 January 2018

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Toward maintaining the genome: DNA damage and replication checkpoints

21 January 2018

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Radiosensitivity in ataxia-telangiectasia: a new explanation

21 January 2018

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A human homologue of the Schizosaccharomyces pombe rad1+ checkpoint gene encodes an exonuclease

21 January 2018

1 reference

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Human cyclins A and B1 are differentially located in the cell and undergo cell cycle-dependent nuclear transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

Design of new anticancer therapies targeting cell cycle checkpoint pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

p53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

Preclinical and clinical development of cyclin-dependent kinase modulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

Purification and DNA binding properties of the ataxia-telangiectasia gene product ATM.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

DNA replication is required for the checkpoint response to damaged DNA in Xenopus egg extracts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

Chromosomal stability and the DNA double-stranded break connection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

Human homologs of Schizosaccharomyces pombe rad1, hus1, and rad9 form a DNA damage-responsive protein complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

Roles of replication protein A and DNA-dependent protein kinase in the regulation of DNA replication following DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

Deficiency of human BRCA2 leads to impaired homologous recombination but maintains normal nonhomologous end joining

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

Distinct Initiation and Maintenance Mechanisms Cooperate to Induce G1 Cell Cycle Arrest in Response to DNA Damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

7 January 2021

Transcriptional activation by the human c-Myc oncoprotein in yeast requires interaction with Max.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

7 January 2021

Homologous recombination as a potential target for caffeine radiosensitization in mammalian cells: reduced caffeine radiosensitization in XRCC2 and XRCC3 mutants

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

7 January 2021

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

7 January 2021

Enhanced phosphorylation of p53 by ATM in response to DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

7 January 2021

ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

7 January 2021

Pathways governing G1/S transition and their response to DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

7 January 2021

Mammalian G1- and S-phase checkpoints in response to DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

7 January 2021

Purification and characterization of ATM from human placenta. A manganese-dependent, wortmannin-sensitive serine/threonine protein kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

7 January 2021

14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

7 January 2021

ATR and ATRIP: partners in checkpoint signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

7 January 2021

Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

7 January 2021

Beating a path to Myc

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

7 January 2021

Proteomic screen finds pSer/pThr-binding domain localizing Plk1 to mitotic substrates

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

7 January 2021

Cell cycle checkpoints: preventing an identity crisis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

7 January 2021

The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

7 January 2021

Cdc25 cell-cycle phosphatase as a target of c-myc

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

7 January 2021

ATM-dependent phosphorylation of nibrin in response to radiation exposure

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

7 January 2021

MDC1 is required for the intra-S-phase DNA damage checkpoint

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

7 January 2021

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

7 January 2021

Cell cycle control and cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

7 January 2021

Checkpoints: controls that ensure the order of cell cycle events

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

7 January 2021

DNA damage-induced activation of p53 by the checkpoint kinase Chk2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

7 January 2021

Genome maintenance mechanisms for preventing cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

7 January 2021

Sensing and repairing DNA double-strand breaks

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

7 January 2021

p34(Cdc2) kinase activity is excluded from the nucleus during the radiation-induced G(2) arrest in HeLa cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

7 January 2021

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

1 reference

7 January 2021

Cdc25C interacts with PCNA at G2/M transition

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

7 January 2021

Inhibition of DNA replication by ionizing radiation is mediated by a trans-acting factor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

7 January 2021

Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

7 January 2021

Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

7 January 2021

ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

7 January 2021

MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

7 January 2021

Yeast checkpoint genes in DNA damage processing: implications for repair and arrest

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

7 January 2021

Rapid destruction of human Cdc25A in response to DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

7 January 2021

Linkage of ATM to cell cycle regulation by the Chk2 protein kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

7 January 2021

Principles of CDK regulation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

7 January 2021

Universal control mechanism regulating onset of M-phase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

7 January 2021

Ordering S phase and M phase in the cell cycle

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

7 January 2021

Checkpoint pathways come of age.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

7 January 2021

Inactivation of the p34cdc2-cyclin B complex by the human WEE1 tyrosine kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

7 January 2021

When checkpoints fail

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

7 January 2021

Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

7 January 2021

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

1 reference

7 January 2021

ATM: a mediator of multiple responses to genotoxic stress

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

7 January 2021

Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

7 January 2021

Chfr defines a mitotic stress checkpoint that delays entry into metaphase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

7 January 2021

In search of the tumour-suppressor functions of BRCA1 and BRCA2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

7 January 2021

Myc suppression of the p21 Cip1 Cdk inhibitor influences the outcome of the p53 response to DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

7 January 2021

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

1 reference

7 January 2021

Signal transduction. Capturing polo kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

7 January 2021

Arrest of the cell cycle by the tumour-suppressor BRCA1 requires the CDK-inhibitor p21WAF1/CiP1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

7 January 2021

MDC1 is a mediator of the mammalian DNA damage checkpoint

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

7 January 2021

Smart machines at the DNA replication fork.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

7 January 2021

Cell cycle control of DNA replication.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

7 January 2021

p53 inhibits entry into mitosis when DNA synthesis is blocked

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

7 January 2021

Regulation of the G2/M transition by p53.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

7 January 2021

Requirement for tyrosine phosphorylation of Cdk4 in Gl arrest induced by ultraviolet irradiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

7 January 2021

Different drugs arrest cells at a number of distinct stages in G2.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

7 January 2021

Surfing the p53 network

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

7 January 2021

Caffeine could not efficiently sensitize homologous recombination repair-deficient cells to ionizing radiation-induced killing

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

7 January 2021

Efficient rejoining of radiation-induced DNA double-strand breaks in vertebrate cells deficient in genes of the RAD52 epistasis group.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

7 January 2021

New link in a web of human genes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

7 January 2021

Deficient recovery from potentially lethal radiation damage in ataxia telangiectasia and xeroderma pigmentosum

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

7 January 2021

ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

7 January 2021

D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

7 January 2021

Specific protection against breast cancers by cyclin D1 ablation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

7 January 2021

Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

7 January 2021

The DNA damage response: putting checkpoints in perspective

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

7 January 2021

A cellular survival switch: poly(ADP-ribosyl)ation stimulates DNA repair and silences transcription

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206682

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1206682

1 reference

7 August 2017

1 reference