A single amino acid substitution (N297A) in the conserved NPXXY sequence of the human N-formyl peptide receptor results in inhibition of desensitization and endocytosis, and a dose-dependent shift in p42/44 mitogen-activated protein kinase activatio (Q42998072)

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scientific article published in December 2000

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English	A single amino acid substitution (N297A) in the conserved NPXXY sequence of the human N-formyl peptide receptor results in inhibition of desensitization and endocytosis, and a dose-dependent shift in p42/44 mitogen-activated protein kinase activatio	scientific article published in December 2000

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11085933%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

A single amino acid substitution (N297A) in the conserved NPXXY sequence of the human N-formyl peptide receptor results in inhibition of desensitization and endocytosis, and a dose-dependent shift in p42/44 mitogen-activated protein kinase activation and chemotaxis (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11085933%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

desensitization

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Algirdas J. Jesaitis

2

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2 November 2019

author name string

J M Gripentrog

1

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2 November 2019

H M Miettinen

3

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2 November 2019

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publication date

1 December 2000

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2 November 2019

number of pages

9

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Biochemical Journal

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2 November 2019

352 Pt 2

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2 November 2019

399-407

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PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11085933%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

Eotaxin induces degranulation and chemotaxis of eosinophils through the activation of ERK2 and p38 mitogen-activated protein kinases

1 reference

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A cell's sense of direction

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Dynamics of a chemoattractant receptor in living neutrophils during chemotaxis

1 reference

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Role of arrestins in endocytosis and signaling of alpha2-adrenergic receptor subtypes

1 reference

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Multiple activation steps of the N-formyl peptide receptor

1 reference

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1 reference

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Chemotaxis of chinese hamster ovary cells expressing the human neutrophil formyl peptide receptor: role of signal transduction molecules and alpha5beta1 integrin.

1 reference

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Rhodopsin-family receptors associate with small G proteins to activate phospholipase D.

1 reference

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Essential role for G protein-coupled receptor endocytosis in the activation of mitogen-activated protein kinase.

1 reference

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26 May 2018

Phosphorylation of the N-formyl peptide receptor is required for receptor internalization but not chemotaxis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221471

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Dissociation of chemotaxis from agonist-induced receptor internalization in a lymphocyte cell line transfected with CCR2B. Evidence that directed migration does not require rapid modulation of signaling at the receptor level

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221471

26 May 2018

Desensitization of N-formylpeptide receptor-mediated activation is dependent upon receptor phosphorylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221471

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Structure and function of leukocyte chemoattractant receptors

1 reference

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Regulation of cell motility by mitogen-activated protein kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221471

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PH domains: diverse sequences with a common fold recruit signaling molecules to the cell surface

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221471

26 May 2018

The tyrosine within the NPXnY motif of the human angiotensin II type 1 receptor is involved in mediating signal transduction but is not essential for internalization.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221471

26 May 2018

Functional molecular complexes of human N-formyl chemoattractant receptors and actin

1 reference

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26 May 2018

Binding of low affinity N-formyl peptide receptors to G protein. Characterization of a novel inactive receptor intermediate

1 reference

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Role of phosphorylation in agonist-promoted beta 2-adrenergic receptor sequestration. Rescue of a sequestration-defective mutant receptor by beta ARK1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221471

26 May 2018

Expression of recombinant plasmids in mammalian cells is enhanced by sodium butyrate

1 reference

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The isolation and partial characterization of neutrophil chemotactic factors from Escherichia coli

1 reference

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U50,488H-induced internalization of the human kappa opioid receptor involves a beta-arrestin- and dynamin-dependent mechanism. Kappa receptor internalization is not required for mitogen-activated protein kinase activation

1 reference

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Regulatory interaction of N-formyl peptide chemoattractant receptors with the membrane skeleton in human neutrophils

1 reference

https://pubmed.ncbi.nlm.nih.gov/11085933

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A highly conserved tyrosine residue in G protein-coupled receptors is required for agonist-mediated beta 2-adrenergic receptor sequestration

1 reference

https://pubmed.ncbi.nlm.nih.gov/11085933

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The conserved NPXnY motif present in the gastrin-releasing peptide receptor is not a general sequestration sequence

1 reference

https://pubmed.ncbi.nlm.nih.gov/11085933

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A Conserved NPLFY Sequence Contributes to Agonist Binding and Signal Transduction but Is Not an Internalization Signal for the Type 1 Angiotensin II Receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/11085933

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Angiotensin II receptor endocytosis involves two distinct regions of the cytoplasmic tail. A role for residues on the hydrophobic face of a putative amphipathic helix

1 reference

https://pubmed.ncbi.nlm.nih.gov/11085933

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The conserved seven-transmembrane sequence NP(X)2,3Y of the G-protein-coupled receptor superfamily regulates multiple properties of the beta 2-adrenergic receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/11085933

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential effects of a mitogen-activated protein kinase kinase inhibitor on human neutrophil responses to chemotactic factors

1 reference

https://pubmed.ncbi.nlm.nih.gov/11085933

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural and functional requirements for agonist-induced internalization of the human platelet-activating factor receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/11085933

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The ligand binding site of the formyl peptide receptor maps in the transmembrane region

1 reference

https://pubmed.ncbi.nlm.nih.gov/11085933

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Importance of MEK in neutrophil microbicidal responsiveness

1 reference

https://pubmed.ncbi.nlm.nih.gov/11085933

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

G protein-coupled receptor kinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/11085933

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

G protein signaling events are activated at the leading edge of chemotactic cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/11085933

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of the mitogen-activated protein kinase pathway by a Gq/11-coupled muscarinic receptor is independent of receptor internalization

1 reference

https://pubmed.ncbi.nlm.nih.gov/11085933

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

C-reactive protein inhibits chemotactic peptide-induced p38 mitogen-activated protein kinase activity and human neutrophil movement

1 reference

https://pubmed.ncbi.nlm.nih.gov/11085933

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of Putative Sites of Interaction between the Human Formyl Peptide Receptor and G Protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/11085933

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1042/0264-6021:3520399

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

10.1042/BJ3520399

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11085933%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11085933%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

PubMed publication ID

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11085933%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

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