Conformational transitions in human AP endonuclease 1 and its active site mutant during abasic site repair. (Q43006628)

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6 February 2020

title

Conformational transitions in human AP endonuclease 1 and its active site mutant during abasic site repair (English)

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6 February 2020

2

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6 February 2020

Olga S. Fedorova

5

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6 February 2020

author name string

Lyubov Yu Kanazhevskaya

1

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6 February 2020

Dmitry O Zharkov

3

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6 February 2020

Phyllis R Strauss

4

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6 February 2020

language of work or name

English

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publication date

1 August 2010

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6 February 2020

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6 February 2020

volume

49

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6 February 2020

issue

30

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6 February 2020

page(s)

6451-6461

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Conformational dynamics of human AP endonuclease in base excision and nucleotide incision repair pathways

6 February 2020

cites work

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Enzymatic mechanism of human apurinic/apyrimidinic endonuclease against a THF AP site model substrate

26 May 2018

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Characterization of abasic endonuclease activity of human Ape1 on alternative substrates, as well as effects of ATP and sequence context on AP site incision

26 May 2018

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A dominant-negative form of the major human abasic endonuclease enhances cellular sensitivity to laboratory and clinical DNA-damaging agents

26 May 2018

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Role of active site tyrosines in dynamic aspects of DNA binding by AP endonuclease

26 May 2018

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Pre-steady-state kinetic study of substrate specificity of Escherichia coli formamidopyrimidine--DNA glycosylase

26 May 2018

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DNA repair protein involved in heart and blood development

26 May 2018

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Role of the tryptophan residue in the vicinity of the catalytic center of exonuclease III family AP endonucleases: AP site recognition mechanism

26 May 2018

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Molecular and biological roles of Ape1 protein in mammalian base excision repair

26 May 2018

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Kinetics of substrate recognition and cleavage by human 8-oxoguanine-DNA glycosylase

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Protein-protein interactions and posttranslational modifications in mammalian base excision repair

26 May 2018

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Human apurinic endonuclease 1 (APE1) expression and prognostic significance in osteosarcoma: enhanced sensitivity of osteosarcoma to DNA damaging agents using silencing RNA APE1 expression inhibition

26 May 2018

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Pre-steady-state kinetics shows differences in processing of various DNA lesions by Escherichia coli formamidopyrimidine-DNA glycosylase

26 May 2018

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Repair of abasic sites in DNA.

26 May 2018

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Repair of endogenous DNA damage

26 May 2018

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The apurinic/apyrimidinic endonuclease activity of Ape1/Ref-1 contributes to human glioma cell resistance to alkylating agents and is elevated by oxidative stress

26 May 2018

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The major human abasic endonuclease: formation, consequences and repair of abasic lesions in DNA.

26 May 2018

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Solution structure of an oligonucleotide containing an abasic site: evidence for an unusual deoxyribose conformation

26 May 2018

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Two divalent metal ions in the active site of a new crystal form of human apurinic/apyrimidinic endonuclease, Ape1: implications for the catalytic mechanism

26 May 2018

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Conformation and dynamics of abasic sites in DNA investigated by time-resolved fluorescence of 2-aminopurine

26 May 2018

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Abasic site recognition by two apurinic/apyrimidinic endonuclease families in DNA base excision repair: the 3' ends justify the means

26 May 2018

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Suppression of spontaneous mutagenesis in human cells by DNA base excision-repair

26 May 2018

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DNA-bound structures and mutants reveal abasic DNA binding by APE1 and DNA repair coordination [corrected]

26 May 2018

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Ref-1 regulates the transactivation and pro-apoptotic functions of p53 in vivo.

26 May 2018

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Endogenous apurinic/apyrimidinic sites in genomic DNA of mammalian tissues

26 May 2018

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26 May 2018

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Beyond enzyme kinetics: direct determination of mechanisms by stopped-flow mass spectrometry

26 May 2018

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Substrate binding by human apurinic/apyrimidinic endonuclease indicates a Briggs-Haldane mechanism

26 May 2018

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Improved thermodynamic parameters and helix initiation factor to predict stability of DNA duplexes

26 May 2018

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The redox/DNA repair protein, Ref-1, is essential for early embryonic development in mice.

26 May 2018

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Program DYNAFIT for the analysis of enzyme kinetic data: application to HIV proteinase

26 May 2018

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Instability and decay of the primary structure of DNA

26 May 2018

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A role for the human DNA repair enzyme HAP1 in cellular protection against DNA damaging agents and hypoxic stress

26 May 2018

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Incision Activity of Human Apurinic Endonuclease (Ape) at Abasic Site Analogs in DNA

26 May 2018

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Rate of depurination of native deoxyribonucleic acid

26 May 2018

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Predicting DNA duplex stability from the base sequence

26 May 2018

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Identification and characterization of Ref-1, a nuclear protein that facilitates AP-1 DNA-binding activity

26 May 2018

1 reference

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Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme

26 May 2018

1 reference

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Probing conformational changes in Ape1 during the progression of base excision repair

26 May 2018

1 reference

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A "moving metal mechanism" for substrate cleavage by the DNA repair endonuclease APE-1.

16 August 2018

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Novel role of tyrosine in catalysis by human AP endonuclease 1.

16 August 2018

1 reference

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Blockage of abasic site repair enhances antitumor efficacy of 1,3-bis-(2-chloroethyl)-1-nitrosourea in colon tumor xenografts

16 August 2018

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Stopped-flow kinetic studies of the interaction between Escherichia coli Fpg protein and DNA substrates

16 August 2018

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Alternative nucleotide incision repair pathway for oxidative DNA damage

16 August 2018

1 reference

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The role of Mg2+ and specific amino acid residues in the catalytic reaction of the major human abasic endonuclease: new insights from EDTA-resistant incision of acyclic abasic site analogs and site-directed mutagenesis.

16 August 2018

1 reference

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Oligodeoxynucleotides containing synthetic abasic sites. Model substrates for DNA polymerases and apurinic/apyrimidinic endonucleases.

16 August 2018

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Pre-steady-state kinetic characterization of the AP endonuclease activity of human AP endonuclease 1

16 August 2018

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12 December 2020

Thermodynamic consequences of an abasic lesion in duplex DNA are strongly dependent on base sequence

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12 December 2020

Allosteric enzyme models and their analysis by the theory of graphs

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12 December 2020

Rapid Mixing and Sampling Techniques

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12 December 2020

Single-turnover analysis of mutant human apurinic/apyrimidinic endonuclease

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12 December 2020

Kinetic conformational analysis of human 8-oxoguanine-DNA glycosylase

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Redox regulation of fos and jun DNA-binding activity in vitro

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12 December 2020

Kinetic mechanism of rat polymerase beta-dsDNA interactions. Fluorescence stopped-flow analysis of the cooperative ligand binding to a two-site one-dimensional lattice

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Mapping the protein-DNA interface and the metal-binding site of the major human apurinic/apyrimidinic endonuclease

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12 December 2020

Identifiers

DOI

10.1021/BI100769K

1 reference

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6 February 2020

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6 February 2020

PubMed publication ID

20575528

1 reference