Regulation of Rac1 by simvastatin in endothelial cells: differential roles of AMP-activated protein kinase and calmodulin-dependent kinase kinase-beta. (Q43123382)

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scientific article published on 30 March 2009

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English	Regulation of Rac1 by simvastatin in endothelial cells: differential roles of AMP-activated protein kinase and calmodulin-dependent kinase kinase-beta.	scientific article published on 30 March 2009

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25 January 2020

Regulation of Rac1 by simvastatin in endothelial cells: differential roles of AMP-activated protein kinase and calmodulin-dependent kinase kinase-beta (English)

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25 January 2020

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Juliano L Sartoretto

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Ruqin Kou

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25 January 2020

Thomas Michel

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30 March 2009

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25 January 2020

Journal of Biological Chemistry

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25 January 2020

14734-14743

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25 January 2020

C-terminal phosphorylation of LKB1 is not required for regulation of AMP-activated protein kinase, BRSK1, BRSK2, or cell cycle arrest

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LKB1-dependent signaling pathways

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LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1

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Cytoskeletal activation and altered gene expression in endothelial barrier regulation by simvastatin

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Calcium signaling regulates translocation and activation of Rac.

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Mapping the binding site for the GTP-binding protein Rac-1 on its inhibitor RhoGDI-1

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Inhibition of the Ca2+/calmodulin-dependent protein kinase I cascade by cAMP-dependent protein kinase

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Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase

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Phosphorylation and subcellular translocation of endothelial nitric oxide synthase

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Agonist-modulated regulation of AMP-activated protein kinase (AMPK) in endothelial cells. Evidence for an AMPK -> Rac1 -> Akt -> endothelial nitric-oxide synthase pathway.

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Statins activate AMP-activated protein kinase in vitro and in vivo

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12 December 2020

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AMP-activated protein kinase phosphorylation of endothelial NO synthase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19332549

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Statin-Mediated Inhibition of Rho

1 reference

https://pubmed.ncbi.nlm.nih.gov/19332549

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Direct grafting of RGD-motif-containing peptide on the surface of polycaprolactone films

1 reference

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12 December 2020

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Fluid Shear Stress and NO Decrease the Activity of the Hydroxy-Methylglutaryl Coenzyme A Reductase in Endothelial Cells via the AMP-Activated Protein Kinase and FoxO1

1 reference

https://pubmed.ncbi.nlm.nih.gov/19332549

12 December 2020

based on heuristic

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Identifiers

10.1074/JBC.M808664200

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25 January 2020

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Europe PubMed Central

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25 January 2020

1 reference

Europe PubMed Central

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25 January 2020

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