TGF-beta stimulates biglycan synthesis via p38 and ERK phosphorylation of the linker region of Smad2. (Q43137840)

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19 January 2020

title

TGF-beta stimulates biglycan synthesis via p38 and ERK phosphorylation of the linker region of Smad2 (English)

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19 January 2020

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3

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19 January 2020

Narin Osman

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19 January 2020

Peter J Little

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19 January 2020

author name string

Micah L Burch

1

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19 January 2020

Sundy N Y Yang

2

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19 January 2020

Robel Getachew

4

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19 January 2020

publication date

7 March 2010

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Cellular and Molecular Life Sciences

19 January 2020

published in

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19 January 2020

volume

67

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19 January 2020

issue

12

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19 January 2020

page(s)

2077-2090

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MEK1/2 and p38-like MAP kinase successively mediate H(2)O(2) signaling in Vicia guard cell

19 January 2020

cites work

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Crossref

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The JNK/AP1/ATF2 pathway is involved in H2O2-induced acetylcholinesterase expression during apoptosis

21 January 2018

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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

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Transforming growth factor-beta, cell signaling and cardiovascular disorders

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Distinct patterns of transforming growth factor-beta isoform and receptor expression in human atherosclerotic lesions. Colocalization implicates TGF-beta in fibrofatty lesion development

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12 December 2020

SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7

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12 December 2020

Subendothelial lipoprotein retention as the initiating process in atherosclerosis: update and therapeutic implications

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12 December 2020

Endothelin-1 activates ETA receptors on human vascular smooth muscle cells to yield proteoglycans with increased binding to LDL.

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12 December 2020

Intracellular pH in human arterial smooth muscle. Regulation by Na+/H+ exchange and a novel 5-(N-ethyl-N-isopropyl)amiloride-sensitive Na(+)- and HCO3(-)-dependent mechanism

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12 December 2020

Growth factor-mediated hyper-elongation of glycosaminoglycan chains on biglycan requires transcription and translation.

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12 December 2020

Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction

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12 December 2020

TGF-beta and HGF transmit the signals through JNK-dependent Smad2/3 phosphorylation at the linker regions

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12 December 2020

Non-Smad TGF-beta signals

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12 December 2020

Molecular cloning and characterization of a novel chondroitin sulfate glucuronyltransferase that transfers glucuronic acid to N-acetylgalactosamine.

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12 December 2020

Differential effects of gemfibrozil on migration, proliferation and proteoglycan production in human vascular smooth muscle cells.

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12 December 2020

Activation of p21ras by transforming growth factor beta in epithelial cells

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12 December 2020

Hyperelongated biglycan: the surreptitious initiator of atherosclerosis

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12 December 2020

Smad-dependent and Smad-independent pathways in TGF-beta family signalling

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12 December 2020

Integration of Smad and MAPK pathways: a link and a linker revisited

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12 December 2020

Inhibition of transforming growth factor (TGF)-beta1-induced extracellular matrix with a novel inhibitor of the TGF-beta type I receptor kinase activity: SB-431542

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12 December 2020

Proteoglycans synthesized by arterial smooth muscle cells in the presence of transforming growth factor-beta1 exhibit increased binding to LDLs

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12 December 2020

Proteoglycans synthesized by smooth muscle cells derived from monkey (Macaca nemestrina) aorta

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12 December 2020

TGF-beta signal transduction

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12 December 2020

Thrombin regulates vascular smooth muscle cell proteoglycan synthesis via PAR-1 and multiple downstream signalling pathways

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12 December 2020

Biosynthesis of natural and hyperelongated chondroitin sulfate glycosaminoglycans: new insights into an elusive process

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12 December 2020

Pharmacotherapy of coronary atherosclerosis

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12 December 2020

Transforming growth factor-beta (TGF-beta) type I receptor/ALK5-dependent activation of the GADD45beta gene mediates the induction of biglycan expression by TGF-beta

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12 December 2020

Smad and p38 MAP kinase-mediated signaling of proteoglycan synthesis in vascular smooth muscle

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12 December 2020

Vascular wall proteoglycan synthesis and structure as a target for the prevention of atherosclerosis

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12 December 2020

A mechanism of repression of TGFbeta/ Smad signaling by oncogenic Ras

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12 December 2020

Subendothelial retention of atherogenic lipoproteins in early atherosclerosis

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12 December 2020

The interaction of lipids and lipoproteins with the intercellular matrix of arterial tissue: its possible role in atherogenesis

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12 December 2020

The linker region of Smad2 mediates TGF-beta-dependent ERK2-induced collagen synthesis

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12 December 2020

Early human atherosclerosis: accumulation of lipid and proteoglycans in intimal thickenings followed by macrophage infiltration

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12 December 2020

Investigating the elusive mechanism of glycosaminoglycan biosynthesis

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12 December 2020

Platelet-derived growth factor and transforming growth factor-beta 1 differentially affect the synthesis of biglycan and decorin by monkey arterial smooth muscle cells

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12 December 2020

Regulation of glycosaminoglycan structure and atherogenesis.

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12 December 2020

A central role for the JNK pathway in mediating the antagonistic activity of pro-inflammatory cytokines against transforming growth factor-beta-driven SMAD3/4-specific gene expression.

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12 December 2020

Imatinib inhibits vascular smooth muscle proteoglycan synthesis and reduces LDL binding in vitro and aortic lipid deposition in vivo

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12 December 2020

Regulation of biglycan gene expression by transforming growth factor-beta requires MKK6-p38 mitogen-activated protein Kinase signaling downstream of Smad signaling

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12 December 2020

Cell biology of arterial proteoglycans.

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12 December 2020

10.1007/S00018-010-0315-9

Identifiers

DOI

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19 January 2020

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