Metformin attenuates cardiac fibrosis by inhibiting the TGFbeta1-Smad3 signalling pathway (Q43143850)

14 November 2017

Metformin attenuates cardiac fibrosis by inhibiting the TGFbeta1-Smad3 signalling pathway (English)

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14 November 2017

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Han Xiao

1

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14 November 2017

Xiaowei Ma

2

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14 November 2017

Wei Feng

3

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14 November 2017

Yongnan Fu

4

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14 November 2017

Zhizhen Lu

5

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14 November 2017

Ming Xu

6

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14 November 2017

Qiang Shen

7

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14 November 2017

Yi Zhu

8

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14 November 2017

Youyi Zhang

9

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14 November 2017

3 March 2010

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14 November 2017

Cardiovascular Research

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14 November 2017

87

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14 November 2017

504-513

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14 November 2017

3

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Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group

14 November 2017

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ066

10-year follow-up of intensive glucose control in type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ066

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ066

Metformin induces cardioprotection against ischaemia/reperfusion injury in the rat heart 24 hours after administration

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ066

Activation of AMP-activated protein kinase by metformin improves left ventricular function and survival in heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ066

Metformin prevents progression of heart failure in dogs: role of AMP-activated protein kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ066

Treatment with metformin of non-diabetic men with hypertension, hypertriglyceridaemia and central fat distribution: the BIGPRO 1.2 trial.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ066

Essential role of Smad3 in infarct healing and in the pathogenesis of cardiac remodeling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ066

Targeted disruption of Smad4 in cardiomyocytes results in cardiac hypertrophy and heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ066

AICAR stimulates IL-6 production via p38 MAPK in cardiac fibroblasts in adult mice: a possible role for AMPK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ066

Anoxia-reoxygenation stimulates collagen type-I and MMP-1 expression in cardiac fibroblasts: modulation by the PPAR-gamma ligand pioglitazone

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ066

Activation of PPARdelta inhibits cardiac fibroblast proliferation and the transdifferentiation into myofibroblasts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ066

AMP-activated protein kinase is involved in endothelial NO synthase activation in response to shear stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ066

Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ066

Activation of the AMP-activated protein kinase by the anti-diabetic drug metformin in vivo. Role of mitochondrial reactive nitrogen species

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ066

Metformin prevents alcohol-induced liver injury in the mouse: Critical role of plasminogen activator inhibitor-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ066

The effect of metformin on blood pressure and metabolism in nondiabetic hypertensive patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ066

Fibrosis in heart disease: understanding the role of transforming growth factor-beta in cardiomyopathy, valvular disease and arrhythmia

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ066

Osteogenic actions of the anti-diabetic drug metformin on osteoblasts in culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ066

Effect of metformin on bone marrow progenitor cell differentiation: in vivo and in vitro studies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ066

Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ066

ECM remodeling in hypertensive heart disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ066

TGFbeta-SMAD signal transduction: molecular specificity and functional flexibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ066

Mechanisms of TGF-beta signaling from cell membrane to the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ066

The early-immediate gene EGR-1 is induced by transforming growth factor-beta and mediates stimulation of collagen gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ066

Role of AMP-activated protein kinase in mechanism of metformin action

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ066

Acute metformin therapy confers cardioprotection against myocardial infarction via AMPK-eNOS-mediated signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ066

Activation of AMP-activated protein kinase inhibits protein synthesis associated with hypertrophy in the cardiac myocyte

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ066

Metabolic actions of metformin in the heart can occur by AMPK-independent mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ066

21 January 2018

Identifiers

DOI

10.1093/CVR/CVQ066

1 reference

release_nsyg7flepzbqde3ojehil33vpy

14 November 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/nsyg7flepzbqde3ojehil33vpy

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference