Liver-specific reduction of Mfn2 protein by RNAi results in impaired glycometabolism and lipid homeostasis in BALB/c mice (Q43206562)

16 November 2017

title

Liver-specific reduction of Mfn2 protein by RNAi results in impaired glycometabolism and lipid homeostasis in BALB/c mice (English)

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16 November 2017

2

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16 November 2017

Xiaolin Chen

1

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16 November 2017

publication date

29 December 2009

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Journal of Huazhong University of Science and Technology. Medical Sciences

16 November 2017

published in

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16 November 2017

volume

29

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16 November 2017

issue

6

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16 November 2017

page(s)

689-696

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Mutational analysis of action of mitochondrial fusion factor mitofusin-2.

16 November 2017

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Mitofusin-2 determines mitochondrial network architecture and mitochondrial metabolism. A novel regulatory mechanism altered in obesity

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Long-term administration of estradiol decreases expression of hepatic lipogenic genes and improves insulin sensitivity in ob/ob mice: a possible mechanism is through direct regulation of signal transducer and activator of transcription 3.

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Complementary roles of IRS-1 and IRS-2 in the hepatic regulation of metabolism

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Acute effects in vivo of anti-insulin serum on rates of fatty acid synthesis and activities of acetyl-coenzyme A carboxylase and pyruvate dehydrogenase in liver and epididymal adipose tissue of fed rats

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Molecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunction

21 January 2018

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Expression of Mfn2, the Charcot-Marie-Tooth neuropathy type 2A gene, in human skeletal muscle: effects of type 2 diabetes, obesity, weight loss, and the regulatory role of tumor necrosis factor alpha and interleukin-6.

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Could the low level of expression of the gene encoding skeletal muscle mitofusin-2 account for the metabolic inflexibility of obesity?

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RNA interference targeting Fas protects mice from fulminant hepatitis

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12 December 2020

knocking down liver ccaat/enhancer-binding protein alpha by adenovirus-transduced silent interfering ribonucleic acid improves hepatic gluconeogenesis and lipid homeostasis in db/db mice.

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12 December 2020

Gene silencing of human RAMP2 mediated by short-interfering RNA

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12 December 2020

Gene silencing by systemic delivery of synthetic siRNAs in adult mice

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Mitochondrial dysfunction in NASH: causes, consequences and possible means to prevent it.

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Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development

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Upregulation of peroxisome proliferator-activated receptor gamma coactivator gene (PGC1A) during weight loss is related to insulin sensitivity but not to energy expenditure

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RNAi in mice: a promising approach to decipher gene functions in vivo.

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Impact of mitochondrial ROS production in the pathogenesis of insulin resistance

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Associations between insulin resistance and TNF-alpha in plasma, skeletal muscle and adipose tissue in humans with and without type 2 diabetes.

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Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents.

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12 December 2020

Effectiveness of siRNA uptake in target tissues by various delivery methods

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Reduction of PTP1B by RNAi upregulates the activity of insulin controlled fatty acid synthase promoter.

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Validity of the rates of production and utilization of metabolites as determined by tracer methods in intact animals

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12 December 2020

Knock down of gfp and no tail expression in zebrafish embryo by in vivo-transcribed short hairpin RNA with T7 plasmid system.

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Dynamics of mitochondrial morphology in healthy cells and during apoptosis

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Roles of plasma interleukin-6 and tumor necrosis factor-alpha and FFA and TG in the development of insulin resistance induced by high-fat diet.

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Mitochondria-based model for fetal origin of adult disease and insulin resistance.

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12 December 2020

10.1007/S11596-009-0603-5

Identifiers

DOI

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16 November 2017

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