Cadmium-induced DNA damage triggers G(2)/M arrest via chk1/2 and cdc2 in p53-deficient kidney proximal tubule cells (Q43239275)

17 November 2017

Cadmium-induced DNA damage triggers G(2)/M arrest via chk1/2 and cdc2 in p53-deficient kidney proximal tubule cells (English)

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17 November 2017

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2

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17 November 2017

Ulrich Bork

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17 November 2017

Anna Kuchler

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3

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17 November 2017

Thomas Dittmar

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4

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17 November 2017

Frank Thévenod

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5

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17 November 2017

18 November 2009

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American Journal of Physiology - Renal Physiology

17 November 2017

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17 November 2017

298

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17 November 2017

2

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17 November 2017

F255-65

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DNA damage detection and repair pathways--recent advances with inhibitors of checkpoint kinases in cancer therapy

17 November 2017

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00273.2009

Repair and genetic consequences of endogenous DNA base damage in mammalian cells

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00273.2009

Chk1 and Chk2 kinases in checkpoint control and cancer

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00273.2009

DNA damage response as an anti-cancer barrier: damage threshold and the concept of 'conditional haploinsufficiency'.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00273.2009

DNA damage responses to oxidative stress

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00273.2009

Carcinogenic metal compounds: recent insight into molecular and cellular mechanisms

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00273.2009

CDC25 phosphatases in cancer cells: key players? Good targets?

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00273.2009

Requirement for p53 and p21 to sustain G2 arrest after DNA damage

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00273.2009

p53-Dependent but ATM-independent inhibition of DNA synthesis and G2 arrest in cadmium-treated human fibroblasts

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00273.2009

Cyclin-dependent kinase-1: linking apoptosis to cell cycle and mitotic catastrophe.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00273.2009

The molecular control of DNA damage-induced cell death

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00273.2009

Flow cytofluorometric analysis of cell cycle distributions using propidium iodide. Properties of the method and mathematical analysis of the data

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00273.2009

Mdm2 association with p53 targets its ubiquitination

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00273.2009

cdc25 is a specific tyrosine phosphatase that directly activates p34cdc2.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00273.2009

The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00273.2009

A rapid method for detection of nongenotoxic carcinogens of environmental pollutants using synchronized V79 cells and flow cytometry

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00273.2009

21 January 2018

The Hallmarks of Cancer

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00273.2009

Renal cell carcinoma and occupational exposure to chemicals in Canada

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00273.2009

The many substrates and functions of ATM

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00273.2009

Extracellular signal-regulated kinase-signaling-dependent G2/M arrest and cell death in murine macrophages by cadmium

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00273.2009

Inhibition of Chk1-dependent G2 DNA damage checkpoint radiosensitizes p53 mutant human cells

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00273.2009

Cd(2+)-induced cytochrome c release in apoptotic proximal tubule cells: role of mitochondrial permeability transition pore and Ca(2+) uniporter

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00273.2009

Enhancement of radiation cytotoxicity by UCN-01 in non-small cell lung carcinoma cells

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00273.2009

Mammalian cyclin-dependent kinases

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00273.2009

Cadmium induces conformational modifications of wild-type p53 and suppresses p53 response to DNA damage in cultured cells

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00273.2009

DNA damage-induced apoptosis

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00273.2009

Occupational risk factors for renal cell carcinoma: agent-specific results from a case-control study in Germany. MURC Study Group. Multicenter urothelial and renal cancer study

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00273.2009

Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00273.2009

p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00273.2009

Tyrosine phosphorylation of cdc2 is required for the replication checkpoint in Schizosaccharomyces pombe

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00273.2009

DNA damage-induced cell death by apoptosis.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00273.2009

Regulation of DNA replication by ATR: signaling in response to DNA intermediates

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00273.2009

A simple technique for quantitation of low levels of DNA damage in individual cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00273.2009

An international literature survey of "IARC Group I carcinogens" reported in mainstream cigarette smoke

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00273.2009

Dephosphorylation and activation of a p34cdc2/cyclin B complex in vitro by human CDC25 protein

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00273.2009

Regulation of the G2/M transition by p53.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00273.2009

Cadmium and cellular signaling cascades: to be or not to be?

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00273.2009

Up-regulation of multidrug resistance P-glycoprotein via nuclear factor-kappaB activation protects kidney proximal tubule cells from cadmium- and reactive oxygen species-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00273.2009

Cadmium induces nuclear translocation of beta-catenin and increases expression of c-myc and Abcb1a in kidney proximal tubule cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00273.2009

Potentiation of cytotoxicity of topoisomerase i poison by concurrent and sequential treatment with the checkpoint inhibitor UCN-01 involves disparate mechanisms resulting in either p53-independent clonogenic suppression or p53-dependent mitotic cata

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00273.2009

Mechanisms of mitotic cell death induced by chemotherapy-mediated G2 checkpoint abrogation.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00273.2009

21 January 2018

Surfing the p53 network

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00273.2009

Live or let die: the cell's response to p53

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00273.2009

Molecular and cellular mechanisms of cadmium carcinogenesis

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00273.2009

UCN-01: a potent abrogator of G2 checkpoint function in cancer cells with disrupted p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00273.2009

Immortalization and characterization of proximal tubule cells derived from kidneys of spontaneously hypertensive and normotensive rats

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00273.2009

The p53-mdm-2 autoregulatory feedback loop

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00273.2009

Cadmium induces cell cycle arrest in rat kidney epithelial cells in G2/M phase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00273.2009

ATM, ATR and DNA-PK: initiators of the cellular genotoxic stress responses.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00273.2009

The DNA damage response: putting checkpoints in perspective

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00273.2009

10.1152/AJPRENAL.00273.2009

21 January 2018

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DOI

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17 November 2017

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