Recruitment of PKC-betaII to lipid rafts mediates apoptosis-resistance in chronic lymphocytic leukemia expressing ZAP-70. (Q43243964)

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12 February 2020

title

Recruitment of PKC-betaII to lipid rafts mediates apoptosis-resistance in chronic lymphocytic leukemia expressing ZAP-70 (English)

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12 February 2020

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chronic lymphocytic leukemia

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9

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12 February 2020

author name string

C Meyer zum Büschenfelde

1

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12 February 2020

M Wagner

2

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12 February 2020

G Lutzny

3

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12 February 2020

M Oelsner

4

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12 February 2020

Y Feuerstacke

5

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12 February 2020

T Decker

6

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12 February 2020

C Bogner

7

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12 February 2020

C Peschel

8

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12 February 2020

publication date

12 November 2009

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12 February 2020

number of pages

12

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inferred from page(s)

published in

Leukemia

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12 February 2020

volume

24

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12 February 2020

issue

1

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page(s)

141-152

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Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia

12 February 2020

cites work

1 reference

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ZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR zeta chain

21 January 2018

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Expression of ZAP-70 is associated with increased B-cell receptor signaling in chronic lymphocytic leukemia

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ZAP-70 enhances IgM signaling independent of its kinase activity in chronic lymphocytic leukemia

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ZAP-70 enhances B-cell-receptor signaling despite absent or inefficient tyrosine kinase activation in chronic lymphocytic leukemia and lymphoma B cells.

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miR-15 and miR-16 induce apoptosis by targeting BCL2

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Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane

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Downregulation of Bim, a proapoptotic relative of Bcl-2, is a pivotal step in cytokine-initiated survival signaling in murine hematopoietic progenitors

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Constitutively activated phosphatidylinositol-3 kinase (PI-3K) is involved in the defect of apoptosis in B-CLL: association with protein kinase Cdelta.

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Cyclin-dependent kinase inhibitor Roscovitine induces apoptosis in chronic lymphocytic leukemia cells.

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Bcl-2 phosphorylation required for anti-apoptosis function

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Posttranslational modification of Bcl-2 facilitates its proteasome-dependent degradation: molecular characterization of the involved signaling pathway.

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Tether and trap: regulation of membrane-raft dynamics by actin-binding proteins.

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In the immune synapse, ZAP-70 controls T cell polarization and recruitment of signaling proteins but not formation of the synaptic pattern.

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PKC-beta controls I kappa B kinase lipid raft recruitment and activation in response to BCR signaling

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Differences in phorbol-ester-induced down-regulation of protein kinase C between cell lines

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Survival factor-induced extracellular signal-regulated kinase phosphorylates BIM, inhibiting its association with BAX and proapoptotic activity.

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Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function.

21 January 2018

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Acyclic N-(azacycloalkyl)bisindolylmaleimides: isozyme selective inhibitors of PKCβ

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Human chronic lymphocytic leukemia modeled in mouse by targeted TCL1 expression

21 January 2018

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B cell receptors in TCL1 transgenic mice resemble those of aggressive, treatment-resistant human chronic lymphocytic leukemia

21 January 2018

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PKCbeta is essential for the development of chronic lymphocytic leukemia in the TCL1 transgenic mouse model: validation of PKCbeta as a therapeutic target in chronic lymphocytic leukemia.

21 January 2018

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Mcl-1 expression has in vitro and in vivo significance in chronic lymphocytic leukemia and is associated with other poor prognostic markers.

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BCL-2 phosphorylation modulates sensitivity to the BH3 mimetic GX15-070 (Obatoclax) and reduces its synergistic interaction with bortezomib in chronic lymphocytic leukemia cells.

21 January 2018

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Bcl2's flexible loop domain regulates p53 binding and survival

21 January 2018

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Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737.

21 January 2018

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The Akt/Mcl-1 pathway plays a prominent role in mediating antiapoptotic signals downstream of the B-cell receptor in chronic lymphocytic leukemia B cells

21 January 2018

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Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

21 January 2018

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Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim inhibits BCR stimulation-induced apoptosis and deletion of autoreactive B cells

21 January 2018

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Phase II study of enzastaurin, a protein kinase C beta inhibitor, in patients with relapsed or refractory diffuse large B-cell lymphoma

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B-cell receptor signaling in chronic lymphocytic leukemia cells is regulated by overexpressed active protein kinase C II

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MALT1 directs B cell receptor–induced canonical nuclear factor-κB signaling selectively to the c-Rel subunit

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7 January 2021

Endogenous association of Bim BH3-only protein with Mcl-1, Bcl-xL and Bcl-2 on mitochondria in human B cells

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7 January 2021

Phase I dose escalation and pharmacokinetic study of enzastaurin, an oral protein kinase C beta inhibitor, in patients with advanced cancer

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7 January 2021

Regulation of the proapoptotic BH3-only protein BIM by glucocorticoids, survival signals and proteasome in chronic lymphocytic leukemia cells

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7 January 2021

Identifiers

DOI

10.1038/LEU.2009.216

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19907441%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

12 February 2020

1020234818

0 references

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