Mechanistic dissection of the enzyme complexes involved in biosynthesis of lacticin 3147 and nisin. (Q43248208)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18791001%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

title

Mechanistic dissection of the enzyme complexes involved in biosynthesis of lacticin 3147 and nisin (English)

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14 January 2020

4

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14 January 2020

author name string

Anneke Kuipers

1

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14 January 2020

Jenny Meijer-Wierenga

2

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14 January 2020

Rick Rink

3

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14 January 2020

Gert N Moll

5

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14 January 2020

language of work or name

English

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publication date

12 September 2008

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Applied and Environmental Microbiology

14 January 2020

published in

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14 January 2020

volume

74

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14 January 2020

issue

21

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14 January 2020

page(s)

6591-6597

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Use of lantibiotic synthetases for the preparation of bioactive constrained peptides

14 January 2020

cites work

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Dissection and modulation of the four distinct activities of nisin by mutagenesis of rings A and B and by C-terminal truncation

25 May 2018

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On the regioselectivity of thioether formation by lacticin 481 synthetase

25 May 2018

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25 May 2018

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25 May 2018

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25 May 2018

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Overproduction of wild-type and bioengineered derivatives of the lantibiotic lacticin 3147.

25 May 2018

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The dehydratase activity of lacticin 481 synthetase is highly processive

25 May 2018

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25 May 2018

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Posttranslational conversion of L-serines to D-alanines is vital for optimal production and activity of the lantibiotic lacticin 3147

25 May 2018

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Post-translational modification of therapeutic peptides by NisB, the dehydratase of the lantibiotic nisin

25 May 2018

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25 May 2018

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Maturation by LctT is required for biosynthesis of full-length lantibiotic lacticin 481.

25 May 2018

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NisT, the transporter of the lantibiotic nisin, can transport fully modified, dehydrated, and unmodified prenisin and fusions of the leader peptide with non-lantibiotic peptides.

25 May 2018

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Lacticin 481: in vitro reconstitution of lantibiotic synthetase activity

25 May 2018

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Lantibiotics: structure, biosynthesis and mode of action

25 May 2018

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Specific binding of nisin to the peptidoglycan precursor lipid II combines pore formation and inhibition of cell wall biosynthesis for potent antibiotic activity

25 May 2018

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Use of the cell wall precursor lipid II by a pore-forming peptide antibiotic.

25 May 2018

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Lacticin 3147, a broad-spectrum bacteriocin which selectively dissipates the membrane potential.

25 May 2018

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Characterization of the lacticin 481 operon: the Lactococcus lactis genes lctF, lctE, and lctG encode a putative ABC transporter involved in bacteriocin immunity.

25 May 2018

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Evidence for a multimeric subtilin synthetase complex

25 May 2018

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Biosynthesis of lantibiotic nisin. Posttranslational modification of its prepeptide occurs at a multimeric membrane-associated lanthionine synthetase complex

25 May 2018

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An application in cheddar cheese manufacture for a strain of Lactococcus lactis producing a novel broad-spectrum bacteriocin, lacticin 3147.

25 May 2018

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Characterization of the Lactococcus lactis nisin A operon genes nisP, encoding a subtilisin-like serine protease involved in precursor processing, and nisR, encoding a regulatory protein involved in nisin biosynthesis.

25 May 2018

1 reference

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Biosynthesis and biological activities of lantibiotics with unique post-translational modifications

25 May 2018

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A family of bacteriocin ABC transporters carry out proteolytic processing of their substrates concomitant with export

25 May 2018

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Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa

25 May 2018

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NisC, the cyclase of the lantibiotic nisin, can catalyze cyclization of designed nonlantibiotic peptides

25 May 2018

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15 August 2018

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Identification of essential catalytic residues of the cyclase NisC involved in the biosynthesis of nisin.

15 August 2018

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Complete alanine scanning of the two-component lantibiotic lacticin 3147: generating a blueprint for rational drug design.

15 August 2018

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Engineering dehydro amino acids and thioethers into peptides using lacticin 481 synthetase.

15 August 2018

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An alternative bactericidal mechanism of action for lantibiotic peptides that target lipid II.

15 August 2018

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Structure and mechanism of the lantibiotic cyclase involved in nisin biosynthesis.

15 August 2018

1 reference

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Lantibiotic structures as guidelines for the design of peptides that can be modified by lantibiotic enzymes.

15 August 2018

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Structural characterization of lacticin 3147, a two-peptide lantibiotic with synergistic activity.

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2576704

NisB is required for the dehydration and NisC for the lanthionine formation in the post-translational modification of nisin.

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2576704

Each peptide of the two-component lantibiotic lacticin 3147 requires a separate modification enzyme for activity.

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2576704

Biological and molecular characterization of a two-peptide lantibiotic produced by Lactococcus lactis IFPL105.

15 August 2018

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Characterization of the nisin gene cluster nisABTCIPR of Lactococcus lactis. Requirement of expression of the nisA and nisI genes for development of immunity.

15 August 2018

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Construction of a vector plasmid family and its use for molecular cloning in Streptococcus lactis

15 August 2018

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12 December 2020

Extensive post-translational modification, including serine to D-alanine conversion, in the two-component lantibiotic, lacticin 3147

1 reference

12 December 2020

Controlled overproduction of proteins by lactic acid bacteria

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12 December 2020

A system for the random mutagenesis of the two-peptide lantibiotic lacticin 3147: analysis of mutants producing reduced antibacterial activities

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12 December 2020

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12 December 2020

Evidence for a role of NisT in transport of the lantibiotic nisin produced by Lactococcus lactis N8

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12 December 2020

Transformation of Lactococcus by electroporation

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12 December 2020

The mode of action of the lantibiotic lacticin 3147--a complex mechanism involving specific interaction of two peptides and the cell wall precursor lipid II

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12 December 2020

Identifiers

DOI

10.1128/AEM.01334-08

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18791001%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18791001%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

1 reference