Resolution of P-glycoprotein and non-P-glycoprotein effects on drug permeability using intestinal tissues from mdr1a (-/-) mice. (Q43263789)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11959808%20AND%20SRC:MED&resulttype=core&format=json

9 December 2019

title

Resolution of P-glycoprotein and non-P-glycoprotein effects on drug permeability using intestinal tissues from mdr1a (-/-) mice (English)

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9 December 2019

1

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9 December 2019

author name string

C A O'Neill

2

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9 December 2019

J Bennett

3

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9 December 2019

M Humphrey

4

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9 December 2019

B Henry

5

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9 December 2019

M Rowland

6

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9 December 2019

G Warhurst

7

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9 December 2019

language of work or name

English

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publication date

1 April 2002

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British Journal of Pharmacology

9 December 2019

published in

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9 December 2019

volume

135

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9 December 2019

issue

8

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9 December 2019

page(s)

2038-2046

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Kinetic profiling of P-glycoprotein-mediated drug efflux in rat and human intestinal epithelia.

9 December 2019

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25 May 2018

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Modulation of the permeability of H2 receptor antagonists cimetidine and ranitidine by P-glycoprotein in rat intestine and the human colonic cell line Caco-2.

25 May 2018

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Decreased drug accumulation without increased drug efflux in a novel MRP-overexpressing multidrug-resistant cell line

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Characterization of the regional intestinal kinetics of drug efflux in rat and human intestine and in Caco-2 cells

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25 May 2018

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Membrane transport of drugs in different regions of the intestinal tract of the rat.

25 May 2018

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Disruption of the murine MRP (multidrug resistance protein) gene leads to increased sensitivity to etoposide (VP-16) and increased levels of glutathione.

25 May 2018

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Evidence that the multidrug resistance protein (MRP) functions as a co-transporter of glutathione and natural product toxins

25 May 2018

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Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins

25 May 2018

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Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine

25 May 2018

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25 May 2018

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25 May 2018

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25 May 2018

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25 May 2018

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Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

25 May 2018

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25 May 2018

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Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

25 May 2018

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25 May 2018

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25 May 2018

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25 May 2018

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15 August 2018

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15 August 2018

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15 August 2018

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Inhibition of intestinal P-glycoprotein and effects on etoposide absorption.

15 August 2018

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ATP-dependent transport of lipophilic cytotoxic drugs by membrane vesicles prepared from MRP-overexpressing HL60/ADR cells

15 August 2018

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Involvement of an organic anion transporter (canalicular multispecific organic anion transporter/multidrug resistance-associated protein 2) in gastrointestinal secretion of glutathione conjugates in rats

29 September 2018

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12 December 2020

Calcein is excreted from the intestinal mucosal cell membrane by the active transport system

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12 December 2020

Role of breast cancer resistance protein in the bioavailability and fetal penetration of topotecan

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12 December 2020

Possible involvement of multiple P-glycoprotein-mediated efflux systems in the transport of verapamil and other organic cations across rat intestine

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12 December 2020

Identifiers

DOI

10.1038/SJ.BJP.0704668

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11959808%20AND%20SRC:MED&resulttype=core&format=json

9 December 2019

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11959808%20AND%20SRC:MED&resulttype=core&format=json

9 December 2019

PubMed publication ID

11959808

1 reference