Dominant-negative effects in prion diseases: insights from molecular dynamics simulations on mouse prion protein chimeras (Q43493602)

24 November 2017

title

Dominant-negative effects in prion diseases: insights from molecular dynamics simulations on mouse prion protein chimeras (English)

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24 November 2017

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24 November 2017

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24 November 2017

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24 November 2017

Salvatore Bongarzone

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Giulia Rossetti

object named as

Giulia Rossetti

series ordinal

4

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Xiaojing Cong

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1

object named as

Xiaojing Cong

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24 November 2017

publication date

30 August 2012

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Journal of Biomolecular Structure and Dynamics

24 November 2017

published in

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24 November 2017

volume

31

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24 November 2017

issue

8

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24 November 2017

page(s)

829-840

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Prion Fibrillization Is Mediated by a Native Structural Element That Comprises Helices H2 and H3

24 November 2017

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PRNP variation in UK sporadic and variant Creutzfeldt Jakob disease highlights genetic risk factors and a novel non-synonymous polymorphism

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PrP genotype contributes to determining survival times of sheep with natural scrapie.

21 January 2018

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Normal host prion protein (PrPC) is required for scrapie spread within the central nervous system

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Mice devoid of PrP are resistant to scrapie

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Influence of pH on NMR structure and stability of the human prion protein globular domain

21 January 2018

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Genetic Creutzfeldt-Jakob disease and fatal familial insomnia: insights into phenotypic variability and disease pathogenesis

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The conversion of helix H2 to beta-sheet is accelerated in the monomer and dimer of the prion protein upon T183A mutation

21 January 2018

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Prion protein NMR structure from tammar wallaby (Macropus eugenii) shows that the beta2-alpha2 loop is modulated by long-range sequence effects

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NMR structure of the bank vole prion protein at 20 degrees C contains a structured loop of residues 165-171

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Molecular architecture of human prion protein amyloid: a parallel, in-register beta-structure

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Therapeutic approaches to protein-misfolding diseases

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Cellular prion protein conformation and function

21 January 2018

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Probing the Conformation of a Prion Protein Fibril with Hydrogen Exchange

21 January 2018

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RNA molecules stimulate prion protein conversion

21 January 2018

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Isolation of phosphatidylethanolamine as a solitary cofactor for prion formation in the absence of nucleic acids

21 January 2018

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Mutant prion protein expression causes motor and memory deficits and abnormal sleep patterns in a transgenic mouse model.

21 January 2018

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Detecting prion protein gene mutations by denaturing gradient gel electrophoresis

21 January 2018

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Trans-dominant inhibition of prion propagation in vitro is not mediated by an accessory cofactor

21 January 2018

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PrP genotype and agent effects in scrapie: change in allelic interaction with different isolates of agent in sheep, a natural host of scrapie

21 January 2018

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Prion protein NMR structures of elk and of mouse/elk hybrids

21 January 2018

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21 January 2018

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Molecular conformation and dynamics of the Y145Stop variant of human prion protein in amyloid fibrils

21 January 2018

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GROMACS 4: Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation

21 January 2018

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Human prion protein (PrP) 219K is converted to PrPSc but shows heterozygous inhibition in variant Creutzfeldt-Jakob disease infection

21 January 2018

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VMD: visual molecular dynamics

21 January 2018

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Spontaneous generation of prion infectivity in fatal familial insomnia knockin mice

21 January 2018

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Solution structure of a 142-residue recombinant prion protein corresponding to the infectious fragment of the scrapie isoform

21 January 2018

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Comparison of simple potential functions for simulating liquid water

21 January 2018

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Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features

21 January 2018

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Prediction of amyloid fibril-forming proteins.

21 January 2018

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Evidence for protein X binding to a discontinuous epitope on the cellular prion protein during scrapie prion propagation

21 January 2018

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Heterozygous inhibition in prion infection: the stone fence model

21 January 2018

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Slow conformational dynamics in the hamster prion protein

21 January 2018

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Locally disordered conformer of the hamster prion protein: a crucial intermediate to PrPSc?

21 January 2018

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https://api.crossref.org/works/10.1080%2F07391102.2012.712477

The dominant-negative effect of the Q218K variant of the prion protein does not require protein X.

21 January 2018

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https://api.crossref.org/works/10.1080%2F07391102.2012.712477

Continuum of prion protein structures enciphers a multitude of prion isolate-specified phenotypes.

21 January 2018

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https://api.crossref.org/works/10.1080%2F07391102.2012.712477

Solid-state NMR structural studies of the fibril form of a mutant mouse prion peptide PrP89-143(P101L).

21 January 2018

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Physiology of the prion protein

21 January 2018

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Beta-sheet core of human prion protein amyloid fibrils as determined by hydrogen/deuterium exchange

21 January 2018

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Prion protein NMR structures of cats, dogs, pigs, and sheep

21 January 2018

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The genetics of prion diseases

21 January 2018

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Balancing selection at the prion protein gene consistent with prehistoric kurulike epidemics

21 January 2018

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Recurrent oligomers in proteins: an optimal scheme reconciling accurate and concise backbone representations in automated folding and design studies.

21 January 2018

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Distinct conformations of in vitro and in vivo amyloids of huntingtin-exon1 show different cytotoxicity

21 January 2018

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Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins

21 January 2018

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Horse prion protein NMR structure and comparisons with related variants of the mouse prion protein

21 January 2018

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Dominant-negative inhibition of prion replication in transgenic mice

21 January 2018

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21 January 2018

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NMR structure of the mouse prion protein domain PrP(121-231)

21 January 2018

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Prion protein NMR structure and familial human spongiform encephalopathies

21 January 2018

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Structural facets of disease-linked human prion protein mutants: a molecular dynamic study

21 January 2018

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https://api.crossref.org/works/10.1080%2F07391102.2012.712477

PrP polymorphisms tightly control sheep prion replication in cultured cells

21 January 2018

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https://api.crossref.org/works/10.1080%2F07391102.2012.712477

Helix H1 of the prion protein is rather stable against environmental perturbations: molecular dynamics of mutation and deletion variants of PrP(90-231).

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07391102.2012.712477

Molecular dynamics simulation of dimeric and monomeric forms of human prion protein: insight into dynamics and properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07391102.2012.712477

Codon 219 Lys allele of PRNP is not found in sporadic Creutzfeldt-Jakob disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07391102.2012.712477

Spongiform encephalopathy in transgenic mice expressing a point mutation in the β2-α2 loop of the prion protein

21 January 2018

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https://api.crossref.org/works/10.1080%2F07391102.2012.712477

De novo generation of a transmissible spongiform encephalopathy by mouse transgenesis

21 January 2018

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https://api.crossref.org/works/10.1080%2F07391102.2012.712477

A molecular switch controls interspecies prion disease transmission in mice

21 January 2018

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https://api.crossref.org/works/10.1080%2F07391102.2012.712477

Prion susceptibility and protective alleles exhibit marked geographic differences

21 January 2018

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https://api.crossref.org/works/10.1080%2F07391102.2012.712477

Representing an ensemble of NMR-derived protein structures by a single structure

21 January 2018

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https://api.crossref.org/works/10.1080%2F07391102.2012.712477

Transmission of Creutzfeldt-Jakob disease from humans to transgenic mice expressing chimeric human-mouse prion protein

21 January 2018

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https://api.crossref.org/works/10.1080%2F07391102.2012.712477

Prion propagation in mice expressing human and chimeric PrP transgenes implicates the interaction of cellular PrP with another protein

21 January 2018

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https://api.crossref.org/works/10.1080%2F07391102.2012.712477

Prion recognition elements govern nucleation, strain specificity and species barriers

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07391102.2012.712477

The α-helical C-terminal domain of full-length recombinant PrP converts to an in-register parallel β-sheet structure in PrP fibrils: evidence from solid state nuclear magnetic resonance

21 January 2018

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https://api.crossref.org/works/10.1080%2F07391102.2012.712477

The consequences of pathogenic mutations to the human prion protein

21 January 2018

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https://api.crossref.org/works/10.1080%2F07391102.2012.712477

Pathogenic mutations in the hydrophobic core of the human prion protein can promote structural instability and misfolding

21 January 2018

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https://api.crossref.org/works/10.1080%2F07391102.2012.712477

Unique Structural Characteristics of the Rabbit Prion Protein

21 January 2018

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https://api.crossref.org/works/10.1080%2F07391102.2012.712477

Homozygosity for prion protein alleles encoding glutamine-171 renders sheep susceptible to natural scrapie

21 January 2018

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https://api.crossref.org/works/10.1080%2F07391102.2012.712477

NMR solution structure of the human prion protein

21 January 2018

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https://api.crossref.org/works/10.1080%2F07391102.2012.712477

Particle mesh Ewald: An N⋅log(N) method for Ewald sums in large systems

21 January 2018

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https://api.crossref.org/works/10.1080%2F07391102.2012.712477

Molecular dynamics simulations at constant pressure and/or temperature

21 January 2018

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https://api.crossref.org/works/10.1080%2F07391102.2012.712477

Common Structural Traits across Pathogenic Mutants of the Human Prion Protein and Their Implications for Familial Prion Diseases

21 January 2018

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https://api.crossref.org/works/10.1080%2F07391102.2012.712477

Impact of the tail and mutations G131V and M129V on prion protein flexibility

21 January 2018

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https://api.crossref.org/works/10.1080%2F07391102.2012.712477

The oligomerization properties of prion protein are restricted to the H2H3 domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07391102.2012.712477

10.1080/07391102.2012.712477

21 January 2018

Identifiers

DOI

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24 November 2017

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