Impact of a single amino acid in the variable region 2 of the Old World monkey TRIM5alpha SPRY (B30.2) domain on anti-human immunodeficiency virus type 2 activity. (Q43526177)

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English	Impact of a single amino acid in the variable region 2 of the Old World monkey TRIM5alpha SPRY (B30.2) domain on anti-human immunodeficiency virus type 2 activity.	scientific article

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25 January 2020

Impact of a single amino acid in the variable region 2 of the Old World monkey TRIM5alpha SPRY (B30.2) domain on anti-human immunodeficiency virus type 2 activity (English)

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25 January 2020

Francisco S Domingues

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Ken Kono

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Katarzyna Bozek

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25 January 2020

Tatsuo Shioda

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25 January 2020

Emi E Nakayama

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1 April 2009

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25 January 2020

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Retrovirus resistance factors Ref1 and Lv1 are species-specific variants of TRIM5alpha

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Site-directed mutagenesis by overlap extension using the polymerase chain reaction

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Structural basis for PRYSPRY-mediated tripartite motif (TRIM) protein function

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The human and African green monkey TRIM5alpha genes encode Ref1 and Lv1 retroviral restriction factor activities

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TRIM21 is an IgG receptor that is structurally, thermodynamically, and kinetically conserved

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Comparison of anti-viral activity of rhesus monkey and cynomolgus monkey TRIM5alphas against human immunodeficiency virus type 2 infection

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Baboons as an animal model for human immunodeficiency virus pathogenesis and vaccine development

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Silencing of tripartite motif protein (TRIM) 5alpha mediated anti-HIV-1 activity by truncated mutant of TRIM5alpha

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A specific region of 37 amino acid residues in the SPRY (B30.2) domain of African green monkey TRIM5alpha determines species-specific restriction of simian immunodeficiency virus SIVmac infection

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Balancing selection and the evolution of functional polymorphism in Old World monkey TRIM5alpha

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All three variable regions of the TRIM5alpha B30.2 domain can contribute to the specificity of retrovirus restriction

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Human tripartite motif 5alpha domains responsible for retrovirus restriction activity and specificity

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Two surface-exposed elements of the B30.2/SPRY domain as potency determinants of N-tropic murine leukemia virus restriction by human TRIM5alpha

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The tripartite motif family identifies cell compartments

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Positive selection of primate TRIM5alpha identifies a critical species-specific retroviral restriction domain

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The cytoplasmic body component TRIM5alpha restricts HIV-1 infection in Old World monkeys

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Species-specific variation in the B30.2(SPRY) domain of TRIM5alpha determines the potency of human immunodeficiency virus restriction

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Trim5alpha protein restricts both HIV-1 and murine leukemia virus

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A single amino acid change in the SPRY domain of human Trim5alpha leads to HIV-1 restriction

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