Copper converts the cellular prion protein into a protease-resistant species that is distinct from the scrapie isoform (Q43559600)

24 November 2017

Copper converts the cellular prion protein into a protease-resistant species that is distinct from the scrapie isoform (English)

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24 November 2017

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E Quaglio

1

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24 November 2017

R Chiesa

series ordinal

2

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24 November 2017

D A Harris

series ordinal

3

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24 November 2017

language of work or name

English

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publication date

18 January 2001

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Journal of Biological Chemistry

24 November 2017

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24 November 2017

276

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24 November 2017

14

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24 November 2017

11432-11438

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Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins

24 November 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009666200

Secondary structure analysis of the scrapie-associated protein PrP 27-30 in water by infrared spectroscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009666200

NMR solution structure of the human prion protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009666200

Solution structure of Syrian hamster prion protein rPrP(90-231).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009666200

A cellular gene encodes scrapie PrP 27-30 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009666200

Separation and properties of cellular and scrapie prion proteins

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M009666200

Copper binding to the prion protein: structural implications of four identical cooperative binding sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009666200

Copper binding to octarepeat peptides of the prion protein monitored by mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009666200

Prion protein selectively binds copper(II) ions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009666200

Raman spectroscopic study on the copper(II) binding mode of prion octapeptide and its pH dependence

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009666200

Copper binding to the N-terminal tandem repeat regions of mammalian and avian prion protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009666200

The cellular prion protein binds copper in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009666200

Copper stimulates endocytosis of the prion protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009666200

Prion protein-deficient cells show altered response to oxidative stress due to decreased SOD-1 activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009666200

Prion protein expression and superoxide dismutase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009666200

Reversibility of scrapie inactivation is enhanced by copper.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009666200

Strain-specific prion-protein conformation determined by metal ions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009666200

Histopathological similarities between scrapie and cuprizone toxicity in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009666200

Accumulation of protease-resistant prion protein (PrP) and apoptosis of cerebellar granule cells in transgenic mice expressing a PrP insertional mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009666200

Neurological illness in transgenic mice expressing a prion protein with an insertional mutation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009666200

A mutant prion protein displays an aberrant membrane association when expressed in cultured cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009666200

Ataxia in prion protein (PrP)-deficient mice is associated with upregulation of the novel PrP-like protein doppel

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009666200

Consequences of manganese replacement of copper for prion protein function and proteinase resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009666200

Processing of a cellular prion protein: identification of N- and C-terminal cleavage sites.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009666200

Truncated forms of the human prion protein in normal brain and in prion diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009666200

A conformational transition at the N terminus of the prion protein features in formation of the scrapie isoform

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009666200

Eight prion strains have PrP(Sc) molecules with different conformations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009666200

Doppel is an N-glycosylated, glycosylphosphatidylinositol-anchored protein. Expression in testis and ectopic production in the brains of Prnp(0/0) mice predisposed to Purkinje cell loss

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009666200

Chicken prion tandem repeats form a stable, protease-resistant domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009666200

Copper(II)-induced conformational changes and protease resistance in recombinant and cellular PrP. Effect of protein age and deamidation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009666200

Copper refolding of prion protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009666200

Partial unfolding and refolding of scrapie-associated prion protein: evidence for a critical 16-kDa C-terminal domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009666200

Perturbation of the secondary structure of the scrapie prion protein under conditions that alter infectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009666200

Aggregation and fibrillization of the recombinant human prion protein huPrP90-231.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009666200

A scrapie-like unfolding intermediate of the prion protein domain PrP(121-231) induced by acidic pH.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009666200

Physical studies of conformational plasticity in a recombinant prion protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009666200

Reversible conversion of monomeric human prion protein between native and fibrilogenic conformations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009666200

Multiple folding pathways for heterologously expressed human prion protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009666200

Self-assembly of recombinant prion protein of 106 residues

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009666200

De novo generation of a PrPSc-like conformation in living cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009666200

Pathologic conformations of prion proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009666200

Transmissible and genetic prion diseases share a common pathway of neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009666200

Prion protein of 106 residues creates an artifical transmission barrier for prion replication in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009666200

Prion protein devoid of the octapeptide repeat region restores susceptibility to scrapie in PrP knockout mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009666200

21 January 2018

Identifiers

DOI

10.1074/JBC.M009666200

1 reference

24 November 2017

1 reference