Structure-based mutagenesis reveals distinct functions for Ras switch 1 and switch 2 in Sos-catalyzed guanine nucleotide exchange (Q43595428)

25 November 2017

Structure-based mutagenesis reveals distinct functions for Ras switch 1 and switch 2 in Sos-catalyzed guanine nucleotide exchange (English)

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25 November 2017

Hall BE

1

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25 November 2017

Yang SS

2

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25 November 2017

Boriack-Sjodin PA

3

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25 November 2017

Kuriyan J

4

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25 November 2017

Bar-Sagi D

5

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25 November 2017

language of work or name

English

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publication date

1 May 2001

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Journal of Biological Chemistry

25 November 2017

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25 November 2017

276

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25 November 2017

27629-27637

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25 November 2017

29

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The Sos (Son of sevenless) protein

25 November 2017

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https://api.crossref.org/works/10.1074%2FJBC.M101727200

Proteins regulating Ras and its relatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101727200

Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101727200

Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101727200

Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101727200

The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101727200

In vivo functional analysis of the Ras exchange factor son of sevenless

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101727200

Functional roles for the pleckstrin and Dbl homology regions in the Ras exchange factor Son-of-sevenless

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101727200

The role of the PH domain in the signal-dependent membrane targeting of Sos.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101727200

Inhibition of mSOS-activity by binding of phosphatidylinositol 4,5-P2 to the mSOS pleckstrin homology domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101727200

Activation of Ras and its downstream extracellular signal-regulated protein kinases by the CDC25 homology domain of mouse Son-of-sevenless 1 (mSos1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101727200

N terminus of Sos1 Ras exchange factor: critical roles for the Dbl and pleckstrin homology domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101727200

Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101727200

Regulation of Sos activity by intramolecular interactions

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M101727200

Mutational analysis of a ras catalytic domain

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M101727200

Residues crucial for Ras interaction with GDP-GTP exchangers

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101727200

Identification of residues of the H-ras protein critical for functional interaction with guanine nucleotide exchange factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101727200

Amino acid residues in the CDC25 guanine nucleotide exchange factor critical for interaction with Ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101727200

Identification of residues critical for Ras(17N) growth-inhibitory phenotype and for Ras interaction with guanine nucleotide exchange factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101727200

Involvement of the switch 2 domain of Ras in its interaction with guanine nucleotide exchange factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101727200

Distinct subclasses of small GTPases interact with guanine nucleotide exchange factors in a similar manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101727200

The structural basis of the activation of Ras by Sos

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101727200

Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101727200

Characterization and properties of dominant-negative mutants of the ras-specific guanine nucleotide exchange factor CDC25(Mm).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101727200

Multiple Ras functions can contribute to mammalian cell transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101727200

Influence of guanine nucleotides on complex formation between Ras and CDC25 proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101727200

An open conformation of switch I revealed by the crystal structure of a Mg2+-free form of RHOA complexed with GDP. Implications for the GDP/GTP exchange mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101727200

Definition of the switch surface in the solution structure of Cdc42Hs

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101727200

The crystal structure of human rac1, a member of the rho-family complexed with a GTP analogue

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101727200

Crystal structure of RhoA-GDP and its functional implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101727200

Crystal structure of human RhoA in a dominantly active form complexed with a GTP analogue

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101727200

Structural Basis for Activation of ARF GTPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101727200

A glutamic finger in the guanine nucleotide exchange factor ARNO displaces Mg2+ and the beta-phosphate to destabilize GDP on ARF1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101727200

Structure of the guanine nucleotide exchange factor Sec7 domain of human arno and analysis of the interaction with ARF GTPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101727200

21 January 2018

Identifiers

DOI

10.1074/JBC.M101727200

1 reference

25 November 2017

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