Amino acid determinants in cyclooxygenase-2 oxygenation of the endocannabinoid 2-arachidonylglycerol (Q43636970)

25 November 2017

Amino acid determinants in cyclooxygenase-2 oxygenation of the endocannabinoid 2-arachidonylglycerol (English)

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25 November 2017

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4

C Schneider

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25 November 2017

K R Kozak

1

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25 November 2017

J J Prusakiewicz

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2

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25 November 2017

S W Rowlinson

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3

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25 November 2017

L J Marnett

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5

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25 November 2017

language of work or name

English

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publication date

11 June 2001

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Journal of Biological Chemistry

25 November 2017

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25 November 2017

276

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25 November 2017

30072-30077

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25 November 2017

32

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Detection and Isolation of an Endoperoxide Intermediate in Prostaglandin Biosynthesis

25 November 2017

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https://api.crossref.org/works/10.1074%2FJBC.M104467200

Prostaglandin endoperoxide H synthases (cyclooxygenases)-1 and -2

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M104467200

Prostaglandin G/H synthase isoenzyme 2 expression in fibroblasts: regulation by dexamethasone, mitogens, and oncogenes

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M104467200

Prostaglandin synthase 2.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M104467200

Inflammation, reproduction, cancer and all that.... The regulation and role of the inducible prostaglandin synthase

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M104467200

Cyclooxygenases: structural, cellular, and molecular biology

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M104467200

21 January 2018

Cyclooxygenases 1 and 2

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https://api.crossref.org/works/10.1074%2FJBC.M104467200

Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M104467200

Inducible isoforms of cyclooxygenase and nitric-oxide synthase in inflammation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M104467200

Cloning and expression of rat prostaglandin endoperoxide synthase (cyclooxygenase)-2 cDNA.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M104467200

Synthesis of prostaglandin E2 ethanolamide from anandamide by cyclooxygenase-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104467200

Oxygenation of the endocannabinoid, 2-arachidonylglycerol, to glyceryl prostaglandins by cyclooxygenase-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104467200

Enantiomeric separation of hydroxy eicosanoids by chiral column chromatography: effect of the alcohol modifier.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104467200

Flexibility of the NSAID binding site in the structure of human cyclooxygenase-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104467200

The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104467200

Involvement of arginine 120, glutamate 524, and tyrosine 355 in the binding of arachidonate and 2-phenylpropionic acid inhibitors to the cyclooxygenase active site of ovine prostaglandin endoperoxide H synthase-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104467200

The structural basis of aspirin activity inferred from the crystal structure of inactivated prostaglandin H2 synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104467200

Synthesis and use of iodinated nonsteroidal antiinflammatory drug analogs as crystallographic probes of the prostaglandin H2 synthase cyclooxygenase active site

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104467200

The productive conformation of arachidonic acid bound to prostaglandin synthase

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M104467200

Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M104467200

Molecular cloning, functional expression, and selective regulation of ovine prostaglandin H synthase-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104467200

A single amino acid difference between cyclooxygenase-1 (COX-1) and -2 (COX-2) reverses the selectivity of COX-2 specific inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104467200

Role of Val509 in time-dependent inhibition of human prostaglandin H synthase-2 cyclooxygenase activity by isoform-selective agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104467200

Structural insights into the stereochemistry of the cyclooxygenase reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104467200

Prostaglandin endoperoxide H synthase-1: the functions of cyclooxygenase active site residues in the binding, positioning, and oxygenation of arachidonic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104467200

Analysis of hydroperoxide-induced tyrosyl radicals and lipoxygenase activity in aspirin-treated human prostaglandin H synthase-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104467200

Spatial requirements for 15-(R)-hydroxy-5Z,8Z,11Z, 13E-eicosatetraenoic acid synthesis within the cyclooxygenase active site of murine COX-2. Why acetylated COX-1 does not synthesize 15-(R)-hete

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104467200

Differential activation of peroxisome proliferator-activated receptors by eicosanoids.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104467200

The binding of arachidonic acid in the cyclooxygenase active site of mouse prostaglandin endoperoxide synthase-2 (COX-2). A putative L-shaped binding conformation utilizing the top channel region

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104467200

Rapid inactivation of prostaglandin endoperoxide synthases by N-(carboxyalkyl)maleimides

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104467200

The interaction of arginine 106 of human prostaglandin G/H synthase-2 with inhibitors is not a universal component of inhibition mediated by nonsteroidal anti-inflammatory drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104467200

Altered sensitivity of aspirin-acetylated prostaglandin G/H synthase-2 to inhibition by nonsteroidal anti-inflammatory drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104467200

Stereospecificity of hydrogen abstraction in the conversion of arachidonic acid to 15R-HETE by aspirin-treated cyclooxygenase-2. Implications for the alignment of substrate in the active site

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104467200

Structural requirements for prostaglandin analog interaction with the ovine corpus luteum prostaglandin F2 alpha receptor. Implications for development of a photoaffinity probe

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104467200

21 January 2018

Identifiers

DOI

10.1074/JBC.M104467200

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25 November 2017

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