Regulation of ubiquitination and degradation of p53 in unstressed cells through C-terminal phosphorylation (Q43657451)

25 November 2017

Regulation of ubiquitination and degradation of p53 in unstressed cells through C-terminal phosphorylation (English)

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25 November 2017

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protein ubiquitination

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M V Chernov

1

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25 November 2017

L J Bean

series ordinal

2

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25 November 2017

N Lerner

series ordinal

3

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25 November 2017

G R Stark

series ordinal

4

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25 November 2017

language of work or name

English

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publication date

28 June 2001

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Journal of Biological Chemistry

25 November 2017

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25 November 2017

276

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25 November 2017

31819-31824

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25 November 2017

34

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The p53 tumour suppressor gene

25 November 2017

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https://api.crossref.org/works/10.1074%2FJBC.M103170200

Mutations in the p53 gene occur in diverse human tumour types

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103170200

Heat shock induces transient p53-dependent cell cycle arrest at G1/S.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103170200

p53-dependent induction of WAF1 by cold shock in human glioblastoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103170200

MYC abrogates p53-mediated cell cycle arrest in N-(phosphonacetyl)-L-aspartate-treated cells, permitting CAD gene amplification

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103170200

A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103170200

21 January 2018

p53: puzzle and paradigm

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103170200

Regulation of the p53 tumor suppressor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103170200

Covalent and noncovalent modifiers of the p53 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103170200

UV Irradiation Stimulates Levels of p53 Cellular Tumor Antigen in Nontransformed Mouse Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103170200

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103170200

The p53-mdm-2 autoregulatory feedback loop

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103170200

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103170200

Repression of p53-mediated transcription by MDM2: a dual mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103170200

DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103170200

DNA damage induces phosphorylation of the amino terminus of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103170200

Molecular characterization of the hdm2-p53 interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103170200

Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103170200

DNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103170200

Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103170200

DNA damage-induced activation of p53 by the checkpoint kinase Chk2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103170200

DNA-dependent protein kinase-independent activation of p53 in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103170200

Cooperative phosphorylation at multiple sites is required to activate p53 in response to UV radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103170200

Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103170200

Enhanced phosphorylation of p53 by ATM in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103170200

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103170200

The ataxia-telangiectasia related protein ATR mediates DNA-dependent phosphorylation of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103170200

E1A signaling to p53 involves the p19(ARF) tumor suppressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103170200

Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103170200

Cooperative signals governing ARF-mdm2 interaction and nucleolar localization of the complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103170200

Small peptides activate the latent sequence-specific DNA binding function of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103170200

Regulation of the cryptic sequence-specific DNA-binding function of p53 by protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103170200

Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103170200

Regulation of Mdm2-directed degradation by the C terminus of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103170200

Stabilization and activation of p53 are regulated independently by different phosphorylation events

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103170200

Mdm2 promotes the rapid degradation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103170200

Regulation of p53 expression by the RAS-MAP kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103170200

Ultraviolet radiation, but not gamma radiation or etoposide-induced DNA damage, results in the phosphorylation of the murine p53 protein at serine-389

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103170200

ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103170200

Allosteric activation of latent p53 tetramers

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103170200

Multiple lysine mutations in the C-terminal domain of p53 interfere with MDM2-dependent protein degradation and ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103170200

Multiple C-terminal lysine residues target p53 for ubiquitin-proteasome-mediated degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103170200

p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103170200

MDM2 inhibits p300-mediated p53 acetylation and activation by forming a ternary complex with the two proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103170200

DNA damage activates p53 through a phosphorylation-acetylation cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103170200

The mammalian UV response: c-Jun induction is required for exit from p53-imposed growth arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103170200

p19ARF links the tumour suppressor p53 to Ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103170200

Protein kinase CK1 is a p53-threonine 18 kinase which requires prior phosphorylation of serine 15

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103170200

Phosphorylation of p53 serine 15 increases interaction with CBP

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103170200

The p53 activation and apoptosis induced by DNA damage are reversibly inhibited by salicylate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103170200

21 January 2018

Identifiers

DOI

10.1074/JBC.M103170200

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release_f3bldqaf2rhenm3esxberqeih4

25 November 2017

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Fatcat

https://api.fatcat.wiki/v0/release/f3bldqaf2rhenm3esxberqeih4

mapped directly with Wikidata item

24 November 2022

based on heuristic

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