Molecular dynamics simulation of PNPLA3 I148M polymorphism reveals reduced substrate access to the catalytic cavity (Q43670289)

25 November 2017

Molecular dynamics simulation of PNPLA3 I148M polymorphism reveals reduced substrate access to the catalytic cavity (English)

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25 November 2017

Yong-Ning Xin

1

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25 November 2017

Yuqi Zhao

2

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25 November 2017

Zhong-Hua Lin

3

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25 November 2017

Xiangjun Jiang

4

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25 November 2017

Shi-Ying Xuan

5

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25 November 2017

Jingfei Huang

6

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25 November 2017

language of work or name

English

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publication date

5 November 2012

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25 November 2017

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25 November 2017

81

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25 November 2017

3

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25 November 2017

406-414

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Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities

25 November 2017

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https://api.crossref.org/works/10.1002%2FPROT.24199

Adiponutrin, a transmembrane protein corresponding to a novel dietary- and obesity-linked mRNA specifically expressed in the adipose lineage

21 January 2018

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https://api.crossref.org/works/10.1002%2FPROT.24199

A feed-forward loop amplifies nutritional regulation of PNPLA3

21 January 2018

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https://api.crossref.org/works/10.1002%2FPROT.24199

Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease

21 January 2018

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https://api.crossref.org/works/10.1002%2FPROT.24199

Long-term follow-up of patients with NAFLD and elevated liver enzymes

21 January 2018

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https://api.crossref.org/works/10.1002%2FPROT.24199

Genetic variance in the adiponutrin gene family and childhood obesity.

21 January 2018

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https://api.crossref.org/works/10.1002%2FPROT.24199

Variant in PNPLA3 is associated with alcoholic liver disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24199

A common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24199

A nonsynonymous gene variant in the adiponutrin gene is associated with nonalcoholic fatty liver disease severity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24199

Morbid obesity exposes the association between PNPLA3 I148M (rs738409) and indices of hepatic injury in individuals of European descent

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24199

Dissociation between fatty liver and insulin resistance in humans carrying a variant of the patatin-like phospholipase 3 gene

21 January 2018

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https://api.crossref.org/works/10.1002%2FPROT.24199

A sequence variation (I148M) in PNPLA3 associated with nonalcoholic fatty liver disease disrupts triglyceride hydrolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24199

A systematic analysis of heart transcriptome highlights divergent cardiovascular disease pathways between animal models and humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24199

Functional protein divergence in the evolution of Homo sapiens

21 January 2018

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https://api.crossref.org/works/10.1002%2FPROT.24199

Effects of point mutations in pVHL on the binding of HIF-1α.

21 January 2018

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https://api.crossref.org/works/10.1002%2FPROT.24199

Oncogenic mutations counteract intrinsic disorder in the EGFR kinase and promote receptor dimerization

21 January 2018

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https://api.crossref.org/works/10.1002%2FPROT.24199

The Universal Protein Resource (UniProt) in 2010

21 January 2018

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https://api.crossref.org/works/10.1002%2FPROT.24199

The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling

21 January 2018

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https://api.crossref.org/works/10.1002%2FPROT.24199

The crystal structure, mutagenesis, and activity studies reveal that patatin is a lipid acyl hydrolase with a Ser-Asp catalytic dyad

21 January 2018

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https://api.crossref.org/works/10.1002%2FPROT.24199

Stereochemistry of polypeptide chain configurations

21 January 2018

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https://api.crossref.org/works/10.1002%2FPROT.24199

Comparison of simple potential functions for simulating liquid water

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24199

Scalable molecular dynamics with NAMD

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24199

Extending the treatment of backbone energetics in protein force fields: limitations of gas-phase quantum mechanics in reproducing protein conformational distributions in molecular dynamics simulations

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24199

Importance of the CMAP correction to the CHARMM22 protein force field: dynamics of hen lysozyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24199

Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24199

Fully automated molecular mechanics based induced fit protein-ligand docking method.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24199

Contribution of conformer focusing to the uncertainty in predicting free energies for protein-ligand binding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24199

Homozygosity for the patatin-like phospholipase-3/adiponutrin I148M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24199

Behavior therapy for nonalcoholic fatty liver disease: The need for a multidisciplinary approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24199

21 January 2018

Identifiers

DOI

10.1002/PROT.24199

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25 November 2017

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