Accessible mutational trajectories for the evolution of pyrimethamine resistance in the malaria parasite Plasmodium vivax (Q43757497)

26 November 2017

Accessible mutational trajectories for the evolution of pyrimethamine resistance in the malaria parasite Plasmodium vivax (English)

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26 November 2017

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3

Daniel L Hartl

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26 November 2017

Pan-Pan Jiang

1

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PubMed ID

24071997

26 November 2017

Russell B Corbett-Detig

series ordinal

2

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PubMed ID

24071997

26 November 2017

Elena R Lozovsky

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4

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26 November 2017

27 September 2013

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Journal of Molecular Evolution

26 November 2017

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26 November 2017

77

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26 November 2017

3

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26 November 2017

81-91

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https://scigraph.springernature.com/pub.10.1007/s00239-013-9582-z

26 November 2017

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Compensatory mutations restore fitness during the evolution of dihydrofolate reductase

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Diminishing returns epistasis among beneficial mutations decelerates adaptation

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Antifolate resistance due to new and known Plasmodium falciparum dihydrofolate reductase mutations expressed in yeast

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Amino acid changes linked to pyrimethamine resistance in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum

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Sequence variations in the Plasmodium vivax dihydrofolate reductase-thymidylate synthase gene and their relationship with pyrimethamine resistance

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Dihydrofolate reductase mutations in Plasmodium vivax from Indonesia and therapeutic response to sulfadoxine plus pyrimethamine

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Antifolates can have a role in the treatment of Plasmodium vivax

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Multiple origins of resistance-conferring mutations in Plasmodium vivax dihydrofolate reductase

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Construction of a dihydrofolate reductase-deficient mutant of Escherichia coli by gene replacement

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Drug-resistant malaria

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Spontaneous mutations in diploid Saccharomyces cerevisiae: more beneficial than expected

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Drug concentration heterogeneity facilitates the evolution of drug resistance.

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Reduced impact of pyrimethamine drug pressure on Plasmodium malariae dihydrofolate reductase gene

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Molecular characterization of dihydrofolate reductase in relation to antifolate resistance in Plasmodium vivax

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Stepwise acquisition of pyrimethamine resistance in the malaria parasite

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Adaptive copy number evolution in malaria parasites

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The malaria parasite Plasmodium vivax exhibits greater genetic diversity than Plasmodium falciparum

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Plasmodium vivax vaccine research: insights from Colombian studies

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simuPOP: a forward-time population genetics simulation environment

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Evidence that a point mutation in dihydrofolate reductase-thymidylate synthase confers resistance to pyrimethamine in falciparum malaria

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Pyrimethamine-sulfadoxine resistance in Plasmodium falciparum: what next?

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Mefloquine pharmacokinetic-pharmacodynamic models: implications for dosing and resistance.

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Focus on Plasmodium vivax

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Therapeutic efficacies of artesunate-sulfadoxine-pyrimethamine and chloroquine-sulfadoxine-pyrimethamine in vivax malaria pilot studies: relationship to Plasmodium vivax dhfr mutations

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Diminishing returns and tradeoffs constrain the laboratory optimization of an enzyme

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Drug resistance in Plasmodium falciparum from the Chittagong Hill Tracts, Bangladesh

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Evolution of an antibiotic resistance enzyme constrained by stability and activity trade-offs

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Darwinian evolution can follow only very few mutational paths to fitter proteins

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Interaction of pyrimethamine, cycloguanil, WR99210 and their analogues with Plasmodium falciparum dihydrofolate reductase: structural basis of antifolate resistance

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12 December 2020

Clinical studies of atovaquone, alone or in combination with other antimalarial drugs, for treatment of acute uncomplicated malaria in Thailand

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12 December 2020

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12 December 2020

A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae

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Identifiers

DOI

1 reference

26 November 2017

1 reference

PubMed ID

24071997