Cyclosporine inhibition of hepatic and intestinal CYP3A4, uptake and efflux transporters: application of PBPK modeling in the assessment of drug-drug interaction potential (Q43767845)

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English	Cyclosporine inhibition of hepatic and intestinal CYP3A4, uptake and efflux transporters: application of PBPK modeling in the assessment of drug-drug interaction potential	scientific article

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scholarly article

1 reference

Europe PubMed Central

26 November 2017

Cyclosporine inhibition of hepatic and intestinal CYP3A4, uptake and efflux transporters: application of PBPK modeling in the assessment of drug-drug interaction potential (English)

1 reference

Europe PubMed Central

26 November 2017

drug interaction

0 references

1 reference

based on heuristic

inferred from title

Aleksandra Galetin

object named as

Aleksandra Galetin

7

0 references

author name string

Michael Gertz

1

1 reference

Europe PubMed Central

26 November 2017

Catherine M Cartwright

2

1 reference

Europe PubMed Central

26 November 2017

Michael J Hobbs

3

1 reference

Europe PubMed Central

26 November 2017

Kathryn E Kenworthy

4

1 reference

Europe PubMed Central

26 November 2017

Malcolm Rowland

5

1 reference

Europe PubMed Central

26 November 2017

J Brian Houston

6

1 reference

Europe PubMed Central

26 November 2017

publication date

22 November 2012

1 reference

Europe PubMed Central

26 November 2017

Pharmaceutical Research

1 reference

Europe PubMed Central

26 November 2017

30

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Europe PubMed Central

26 November 2017

3

1 reference

Europe PubMed Central

26 November 2017

761-780

1 reference

Europe PubMed Central

26 November 2017

Multiple inhibition mechanisms and prediction of drug-drug interactions: status of metabolism and transporter models as exemplified by gemfibrozil-drug interactions.

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0918-Y

21 January 2018

In vitro and in silico strategies to identify OATP1B1 inhibitors and predict clinical drug-drug interactions

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0918-Y

21 January 2018

Membrane transporters in drug development

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0918-Y

21 January 2018

Transporter-mediated drug--drug interactions involving OATP substrates: predictions based on in vitro inhibition studies.

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0918-Y

21 January 2018

Drug and bile acid transporters in rosuvastatin hepatic uptake: function, expression, and pharmacogenetics.

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0918-Y

21 January 2018

Involvement of multiple transporters in the hepatobiliary transport of rosuvastatin

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0918-Y

21 January 2018

Pharmacokinetics of orally and intravenously administered cyclosporine in pre-kidney transplant patients

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0918-Y

21 January 2018

Alterations in cyclosporin A pharmacokinetics and metabolism during treatment with St John's wort in renal transplant patients

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0918-Y

21 January 2018

The kinetics of cyclosporine and its metabolites in bone marrow transplant patients

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0918-Y

21 January 2018

Cyclosporine A, but not tacrolimus, shows relevant inhibition of organic anion-transporting protein 1B1-mediated transport of atorvastatin

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0918-Y

21 January 2018

Physiologically based pharmacokinetics of cyclosporine A: reevaluation of dose-nonlinear kinetics in rats.

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0918-Y

21 January 2018

Physiologic modeling of cyclosporin kinetics in rat and man.

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0918-Y

21 January 2018

Physiologically based pharmacokinetic modeling of intestinal first-pass metabolism of CYP3A substrates with high intestinal extraction.

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0918-Y

21 January 2018

A compartmental absorption and transit model for estimating oral drug absorption.

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0918-Y

21 January 2018

Use of mechanistic modeling to assess interindividual variability and interspecies differences in active uptake in human and rat hepatocytes

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0918-Y

21 January 2018

A comprehensive assessment of repaglinide metabolic pathways: impact of choice of in vitro system and relative enzyme contribution to in vitro clearance

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0918-Y

21 January 2018

Inhibition of transporter-mediated hepatic uptake as a mechanism for drug-drug interaction between cerivastatin and cyclosporin A.

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0918-Y

21 January 2018

Inhibition of Organic Anion Transporting Polypeptide-Mediated Hepatic Uptake Is the Major Determinant in the Pharmacokinetic Interaction between Bosentan and Cyclosporin A in the Rat

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0918-Y

21 January 2018

Inhibition of human organic anion transporting polypeptide OATP 1B1 as a mechanism of drug-induced hyperbilirubinemia

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0918-Y

21 January 2018

Estimation of the increase in solubility of drugs as a function of bile salt concentration.

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0918-Y

21 January 2018

Cyclosporin: pharmacokinetics and detailed studies of plasma and erythrocyte binding during intravenous and oral administration.

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0918-Y

21 January 2018

Effect of food on the pharmacokinetics of cyclosporine in healthy subjects following oral and intravenous administration

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0918-Y

21 January 2018

Gender-dependent racial difference in disposition of cyclosporine among healthy African American and white volunteers

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0918-Y

21 January 2018

Prediction of human intestinal first-pass metabolism of 25 CYP3A substrates from in vitro clearance and permeability data.

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0918-Y

21 January 2018

Human jejunal permeability of cyclosporin A: influence of surfactants on P-glycoprotein efflux in Caco-2 cells

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0918-Y

21 January 2018

The absorption site of cyclosporin in the human gastrointestinal tract

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0918-Y

21 January 2018

Intestinal permeability and its relevance for absorption and elimination

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0918-Y

21 January 2018

Grapefruit juice-drug interaction studies as a method to assess the extent of intestinal availability: utility and limitations.

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0918-Y

21 January 2018

Selection of alternative CYP3A4 probe substrates for clinical drug interaction studies using in vitro data and in vivo simulation

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0918-Y

21 January 2018

Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions.

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0918-Y

21 January 2018

Effects of the SLCO1B1*1B haplotype on the pharmacokinetics and pharmacodynamics of repaglinide and nateglinide

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0918-Y

21 January 2018

Different effects of SLCO1B1 polymorphism on the pharmacokinetics and pharmacodynamics of repaglinide and nateglinide

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0918-Y

21 January 2018

The effect of SLCO1B1 polymorphism on repaglinide pharmacokinetics persists over a wide dose range

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0918-Y

21 January 2018

Polymorphic organic anion transporting polypeptide 1B1 is a major determinant of repaglinide pharmacokinetics

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0918-Y

21 January 2018

Cyclosporine markedly raises the plasma concentrations of repaglinide

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0918-Y

21 January 2018

Substrate-dependent drug-drug interactions between gemfibrozil, fluvastatin and other organic anion-transporting peptide (OATP) substrates on OATP1B1, OATP2B1, and OATP1B3.

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0918-Y

21 January 2018

Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0918-Y

21 January 2018

Is cyclosporin A an inhibitor of drug metabolism?

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0918-Y

21 January 2018

In vivo CYP3A activity is significantly lower in cyclosporine-treated as compared with tacrolimus-treated renal allograft recipients.

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0918-Y

21 January 2018

Pharmacokinetics and response to pravastatin in paediatric patients with familial hypercholesterolaemia and in paediatric cardiac transplant recipients in relation to polymorphisms of the SLCO1B1 and ABCB1 genes

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0918-Y

21 January 2018

Comparative Bioavailability of the Microemulsion Formulation of Cyclosporine (Neoral) With a Generic Dispersion Formulation (Cicloral) in Young Healthy Male Volunteers

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0918-Y

21 January 2018

SLCO1B1 polymorphism and sex affect the pharmacokinetics of pravastatin but not fluvastatin

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0918-Y

21 January 2018

SLCO1B1 polymorphism markedly affects the pharmacokinetics of simvastatin acid

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0918-Y

21 January 2018

Correlations between calcineurin phosphatase inhibition and cyclosporine metabolites concentrations in kidney transplant recipients: implications for immunoassays

1 reference

https://pubmed.ncbi.nlm.nih.gov/23179780

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Consensus document: Hawk's Cay meeting on therapeutic drug monitoring of cyclosporine

1 reference

https://pubmed.ncbi.nlm.nih.gov/23179780

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduced inter- and intraindividual variability in cyclosporine pharmacokinetics from a microemulsion formulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/23179780

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dose-dependent pharmacokinetics of cyclosporin A in rats: events in tissues.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23179780

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple-dose pharmacokinetics, safety, and tolerability of bosentan, an endothelin receptor antagonist, in healthy male volunteers

1 reference

https://pubmed.ncbi.nlm.nih.gov/23179780

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impact of parallel pathways of drug elimination and multiple cytochrome P450 involvement on drug-drug interactions: CYP2D6 paradigm.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23179780

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Unusual solubility behaviour of cyclosporin A in aqueous media

1 reference

https://pubmed.ncbi.nlm.nih.gov/23179780

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclosporin: erythrocyte binding and an examination of its use to estimate unbound concentration.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23179780

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of grapefruit juice on the pharmacokinetics of microemulsion cyclosporine and its metabolite in healthy volunteers: does the formulation difference matter?

1 reference

https://pubmed.ncbi.nlm.nih.gov/23179780

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effects of portal shunts on intestinal cytochrome P450 3A activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/23179780

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biliary Excretion of Cyclosporine in Liver Transplant Patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/23179780

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclosporine metabolite concentrations in the blood of liver, heart, kidney, and bone marrow transplant patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/23179780

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-term cyclosporine pharmacokinetic changes in renal transplant recipients: effects of binding and metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/23179780

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Disposition of intravenous and oral cyclosporine after administration with grapefruit juice

1 reference

https://pubmed.ncbi.nlm.nih.gov/23179780

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Physiologically based pharmacokinetic study on a cyclosporin derivative, SDZ IMM 125

1 reference

https://pubmed.ncbi.nlm.nih.gov/23179780

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effects of food on the dissolution of poorly soluble drugs in human and in model small intestinal fluids

1 reference

https://pubmed.ncbi.nlm.nih.gov/23179780

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Use of transporter knockdown Caco-2 cells to investigate the in vitro efflux of statin drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/23179780

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclosporin pharmacokinetics in heart-lung transplant recipients with cystic fibrosis. Effects of pancreatic enzymes and ranitidine

1 reference

https://pubmed.ncbi.nlm.nih.gov/23179780

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of interintestinal and intraintestinal variations in human CYP3A-dependent metabolism.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23179780

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A prospective cross-over study comparing the pharmacokinetics of cyclosporine A and its metabolites after oral versus short-time intravenous cyclosporine A administration in pre-heart transplant patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/23179780

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Performance and specificity of monoclonal immunoassays for cyclosporine monitoring: how specific is specific?

1 reference

https://pubmed.ncbi.nlm.nih.gov/23179780

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Physiologically based pharmacokinetics of cyclosporine A: extension to tissue distribution kinetics in rats and scale-up to human

1 reference

https://pubmed.ncbi.nlm.nih.gov/23179780

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S11095-012-0918-Y

1 reference

Europe PubMed Central

26 November 2017

1 reference

Europe PubMed Central

26 November 2017

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