A defect in Nrf2 signaling constitutes a mechanism for cellular stress hypersensitivity in a genetic rat model of type 2 diabetes (Q43788237)

26 November 2017

A defect in Nrf2 signaling constitutes a mechanism for cellular stress hypersensitivity in a genetic rat model of type 2 diabetes (English)

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26 November 2017

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2

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26 November 2017

Milad S Bitar

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26 November 2017

30 August 2011

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American Journal of Physiology - Endocrinology and Metabolism

26 November 2017

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26 November 2017

301

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26 November 2017

6

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26 November 2017

E1119-29

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Nuclear factor erythroid 2-related factor 2 deletion impairs glucose tolerance and exacerbates hyperglycemia in type 1 diabetic mice.

26 November 2017

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https://api.crossref.org/works/10.1152%2FAJPENDO.00047.2011

Mitochondrial metabolism of reactive oxygen species.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00047.2011

Role of glutathione depletion and reactive oxygen species generation in apoptotic signaling in a human B lymphoma cell line.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00047.2011

Nrf transcription factors in keratinocytes are essential for skin tumor prevention but not for wound healing

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00047.2011

High-capacity redox control at the plasma membrane of mammalian cells: trans-membrane, cell surface, and serum NADH-oxidases.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00047.2011

Impaired liver regeneration in Nrf2 knockout mice: role of ROS-mediated insulin/IGF-1 resistance

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00047.2011

Inflammation and apoptosis in aortic tissues of aged type II diabetes: amelioration with alpha-lipoic acid through phosphatidylinositol 3-kinase/Akt- dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00047.2011

Alpha-lipoic acid mitigates insulin resistance in Goto-Kakizaki rats

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00047.2011

Nrf2 transcription factor, a novel target of keratinocyte growth factor action which regulates gene expression and inflammation in the healing skin wound

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00047.2011

Advances in protein kinase B signalling: AKTion on multiple fronts

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00047.2011

Sulforaphane protects astrocytes against oxidative stress and delayed death caused by oxygen and glucose deprivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00047.2011

Calorie restriction attenuates age-related alterations in the plasma membrane antioxidant system in rat liver

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00047.2011

The role of Keap1 in cellular protective responses

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00047.2011

Stabilization of Nrf2 protein by D3T provides protection against ethanol-induced apoptosis in PC12 cells

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00047.2011

ATP-induced inhibition of mitochondrial ATPase by oligomycin

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00047.2011

Cellular stress responses: cell survival and cell death

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00047.2011

Review of molecular mechanisms involved in the activation of the Nrf2-ARE signaling pathway by chemopreventive agents.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00047.2011

Nrf2-regulated glutathione recycling independent of biosynthesis is critical for cell survival during oxidative stress

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00047.2011

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00047.2011

Proliferation, oxidative stress and cell death in cells exposed to 872 MHz radiofrequency radiation and oxidants.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00047.2011

Life and death: metabolic rate, membrane composition, and life span of animals.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00047.2011

Calorie restriction up-regulates the plasma membrane redox system in brain cells and suppresses oxidative stress during aging

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00047.2011

GSK-3beta acts upstream of Fyn kinase in regulation of nuclear export and degradation of NF-E2 related factor 2.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00047.2011

Production of reactive oxygen species due to metabolic activation of butylated hydroxyanisole

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00047.2011

Tyrosine phosphorylation controls nuclear export of Fyn, allowing Nrf2 activation of cytoprotective gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00047.2011

Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00047.2011

Phosphatidylinositol 3-kinase, not extracellular signal-regulated kinase, regulates activation of the antioxidant-responsive element in IMR-32 human neuroblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00047.2011

Nrf2 signaling, a mechanism for cellular stress resistance in long-lived mice

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00047.2011

Genetic dissection of systemic autoimmune disease in Nrf2-deficient mice

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00047.2011

Intracellular localization and preassembly of the NADPH oxidase complex in cultured endothelial cells

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00047.2011

Molecular mechanisms of Nrf2-mediated antioxidant response

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00047.2011

Increased susceptibility of Nrf2-null mice to 1-bromopropane-induced hepatotoxicity

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00047.2011

Coordinate regulation of enzyme markers for inflammation and for protection against oxidants and electrophiles.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00047.2011

Ascorbate recycling in human erythrocytes: role of GSH in reducing dehydroascorbate

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00047.2011

The human copper-zinc superoxide dismutase gene (SOD1) proximal promoter is regulated by Sp1, Egr-1, and WT1 via non-canonical binding sites

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00047.2011

Genetic or pharmacologic amplification of nrf2 signaling inhibits acute inflammatory liver injury in mice

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00047.2011

Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00047.2011

Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00047.2011

Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00047.2011

CDDO-Im protects from acetaminophen hepatotoxicity through induction of Nrf2-dependent genes

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00047.2011

The selective detection of mitochondrial superoxide by live cell imaging

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00047.2011

NAD(P)H:quinone oxidoreductase 1 (NQO1): chemoprotection, bioactivation, gene regulation and genetic polymorphisms

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00047.2011

Glycogen synthase kinase-3beta inhibits the xenobiotic and antioxidant cell response by direct phosphorylation and nuclear exclusion of the transcription factor Nrf2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00047.2011

Nrf2 as a master redox switch in turning on the cellular signaling involved in the induction of cytoprotective genes by some chemopreventive phytochemicals

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00047.2011

Novel Nox inhibitor VAS2870 attenuates PDGF-dependent smooth muscle cell chemotaxis, but not proliferation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00047.2011

Apoptosis and necrosis: intracellular ATP level as a determinant for cell death modes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00047.2011

Methylmercury toxicity and Nrf2-dependent detoxification in astrocytes

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00047.2011

Nrf2-deficient female mice develop lupus-like autoimmune nephritis

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00047.2011

10.1152/AJPENDO.00047.2011

21 January 2018

Identifiers

DOI

1 reference

26 November 2017

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PubMed ID

21878664