A novel conditional Akt 'survival switch' reversibly protects cells from apoptosis (Q43918984)

28 November 2017

title

A novel conditional Akt 'survival switch' reversibly protects cells from apoptosis (English)

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28 November 2017

B Li

1

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28 November 2017

S A Desai

2

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28 November 2017

R A MacCorkle-Chosnek

3

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28 November 2017

L Fan

4

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28 November 2017

D M Spencer

5

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28 November 2017

publication date

1 February 2002

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28 November 2017

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28 November 2017

volume

9

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28 November 2017

issue

4

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28 November 2017

page(s)

233-244

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https://scigraph.springernature.com/pub.10.1038/sj.gt.3301641

28 November 2017

exact match

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cites work

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The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

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The activation of protein kinase B by H2O2 or heat shock is mediated by phosphoinositide 3-kinase and not by mitogen-activated protein kinase-activated protein kinase-2

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Dual modulation of cell survival and cell death by beta(2)-adrenergic signaling in adult mouse cardiac myocytes

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Mechanism of protein kinase B activation by cyclic AMP-dependent protein kinase

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PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2.

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Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site

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Inactivation and dephosphorylation of protein kinase Balpha (PKBalpha) promoted by hyperosmotic stress

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Up-regulation of Akt3 in estrogen receptor-deficient breast cancers and androgen-independent prostate cancer lines.

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Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

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New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

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Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

21 January 2018

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Transcriptional activation by tetracyclines in mammalian cells

21 January 2018

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Regulation of protein function through expression of chimaeric proteins

21 January 2018

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Conditional transformation of cells and rapid activation of the mitogen-activated protein kinase cascade by an estradiol-dependent human raf-1 protein kinase

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Controlling signal transduction with synthetic ligands

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Creating conditional mutations in mammals

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Functional analysis of Fas signaling in vivo using synthetic inducers of dimerization

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A proliferation switch for genetically modified cells

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Oligomerization activates c-Raf-1 through a Ras-dependent mechanism

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Synthetic activation of caspases: artificial death switches

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Dimeric ligands define a role for transcriptional activation domains in reinitiation

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A humanized system for pharmacologic control of gene expression

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A general strategy for producing conditional alleles of Src-like tyrosine kinases

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Signal transduction in T lymphocytes using a conditional allele of Sos

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Delivery of a stringent dimerizer-regulated gene expression system in a single retroviral vector

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Akt, a pleckstrin homology domain containing kinase, is activated primarily by phosphorylation

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Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue

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Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP

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Induction of NF-kappaB by the Akt/PKB kinase

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Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-kappaB.

21 January 2018

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Akt stimulates the transactivation potential of the RelA/p65 Subunit of NF-kappa B through utilization of the Ikappa B kinase and activation of the mitogen-activated protein kinase p38.

21 January 2018

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Role of translocation in the activation and function of protein kinase B

21 January 2018

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3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

21 January 2018

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Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B

21 January 2018

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Akt activation by growth factors is a multiple-step process: the role of the PH domain

21 January 2018

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Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

21 January 2018

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Staurosporine, a potent inhibitor of phospholipid/Ca++dependent protein kinase

21 January 2018

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The opposing roles of the Akt and c-Myc signalling pathways in survival from CD95-mediated apoptosis

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Akt signaling: linking membrane events to life and death decisions

21 January 2018

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Three-part inventions: intracellular signaling and induced proximity

21 January 2018

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Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate

21 January 2018

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Construction and characterization of a conditionally active version of the serine/threonine kinase Akt.

21 January 2018

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Inducible gene expression and protein translocation using nontoxic ligands identified by a mammalian three-hybrid screen

21 January 2018

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Transfer of the HSV-tk gene into donor peripheral blood lymphocytes for in vivo modulation of donor anti-tumor immunity after allogeneic bone marrow transplantation

21 January 2018

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A Fas-based suicide switch in human T cells for the treatment of graft-versus-host disease

21 January 2018

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BCL-2 transduction, using a herpes simplex virus amplicon, protects hippocampal neurons from transient global ischemia

21 January 2018

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Adeno-associated virus vector-mediated bcl-2 gene transfer into post-ischemic gerbil brain in vivo: prospects for gene therapy of ischemia-induced neuronal death

21 January 2018

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Reduction of ischemia-reperfusion injury of the liver by in vivo adenovirus-mediated gene transfer of the antiapoptotic Bcl-2 gene

21 January 2018

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Akt activation preserves cardiac function and prevents injury after transient cardiac ischemia in vivo

21 January 2018

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Activated Akt protects the lung from oxidant-induced injury and delays death of mice

21 January 2018

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Cytoprotection of human umbilical vein endothelial cells against apoptosis and CTL-mediated lysis provided by caspase-resistant Bcl-2 without alterations in growth or activation responses

21 January 2018

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Genetic modification of liver grafts with an adenoviral vector encoding the Bcl-2 gene improves organ preservation

21 January 2018

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Genetic cytoprotection of human endothelial cells during preservation time with an adenoviral vector encoding the anti-apoptotic human Bcl-2 gene

21 January 2018

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Gene transfer of the Bcl-2 gene confers cytoprotection to isolated adult porcine pancreatic islets exposed to xenoreactive antibodies and complement

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Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

21 January 2018

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Deficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulation

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Cell death induced by topoisomerase-targeted drugs: more questions than answers

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Dual regulation of platelet protein kinase B

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Frequent activation of AKT2 and induction of apoptosis by inhibition of phosphoinositide-3-OH kinase/Akt pathway in human ovarian cancer

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Hormone-conditional transformation by fusion proteins of c-Abl and its transforming variants

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Protection of CD95-mediated apoptosis by activation of phosphatidylinositide 3-kinase and protein kinase B

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Expression of bcl-2 from a defective herpes simplex virus-1 vector limits neuronal death in focal cerebral ischemia

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Relationship of p220 cleavage during picornavirus infection to 2A proteinase sequencing

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Identifiers

DOI

10.1038/SJ.GT.3301641

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Dimensions Publication ID

28 November 2017

1000107048

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Fatcat ID

release_6hx4yv6dejhvnf2lyroc4edsqu

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Fatcat

https://api.fatcat.wiki/v0/release/6hx4yv6dejhvnf2lyroc4edsqu

24 November 2022

mapped directly with Wikidata item

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