Increased sensitivity to N-methyl-D-aspartate receptor-mediated excitotoxicity in a mouse model of Huntington's disease (Q43925468)

28 November 2017

Increased sensitivity to N-methyl-D-aspartate receptor-mediated excitotoxicity in a mouse model of Huntington's disease (English)

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28 November 2017

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28 November 2017

7

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28 November 2017

6

Patrik Brundin

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28 November 2017

5

Blair R Leavitt

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28 November 2017

8

Lynn A Raymond

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28 November 2017

4

Cheryl L Wellington

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28 November 2017

1

Melinda M Zeron

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28 November 2017

Nansheng Chen

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PubMed ID

11906693

28 November 2017

language of work or name

English

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publication date

1 March 2002

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28 November 2017

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28 November 2017

33

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6

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28 November 2017

849-860

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Abnormalities of striatal projection neurons and N-methyl-D-aspartate receptors in presymptomatic Huntington's disease

28 November 2017

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https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900615-3

7 January 2021

Replication of the neurochemical characteristics of Huntington's disease by quinolinic acid

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https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900615-3

7 January 2021

AMPA receptor desensitization predicts the selective vulnerability of cerebellar Purkinje cells to excitotoxicity

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https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900615-3

7 January 2021

Mitochondrial and extramitochondrial apoptotic signaling pathways in cerebrocortical neurons

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https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900615-3

7 January 2021

Intrinsic membrane properties of neostriatal neurons can account for their low level of spontaneous activity.

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https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900615-3

7 January 2021

Synaptic transmission in the striatum: from plasticity to neurodegeneration

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https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900615-3

7 January 2021

Dopamine and N-methyl-D-aspartate receptor interactions in the neostriatum

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https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900615-3

7 January 2021

NMDA receptor function in mouse models of Huntington disease

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https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900615-3

7 January 2021

Differential sensitivity of medium- and large-sized striatal neurons to NMDA but not kainate receptor activation in the rat.

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https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900615-3

7 January 2021

Differential sensitivity of recombinant N-methyl-D-aspartate receptor subtypes to zinc inhibition.

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https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900615-3

7 January 2021

Subtype-specific enhancement of NMDA receptor currents by mutant huntingtin

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https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900615-3

7 January 2021

Epidermal immunization by a needle-free powder delivery technology: Immunogenicity of influenza vaccine and protection in mice

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https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900615-3

7 January 2021

Glutamate neurotoxicity and diseases of the nervous system

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https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900615-3

7 January 2021

A one-hit model of cell death in inherited neuronal degenerations

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https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900615-3

7 January 2021

Truncated N-terminal fragments of huntingtin with expanded glutamine repeats form nuclear and cytoplasmic aggregates in cell culture.

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https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900615-3

7 January 2021

Lesion of striatal neurons with kainic acid provides a model for Huntington's chorea

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https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900615-3

7 January 2021

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

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https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900615-3

7 January 2021

Excitotoxic injury of the neostriatum: a model for Huntington's disease

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https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900615-3

7 January 2021

Selective sparing of a class of striatal neurons in Huntington's disease

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https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900615-3

7 January 2021

Inhibition of succinate dehydrogenase by malonic acid produces an "excitotoxic" lesion in rat striatum

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https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900615-3

7 January 2021

Nuclear and neuropil aggregates in Huntington's disease: relationship to neuropathology.

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https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900615-3

7 January 2021

The influence of huntingtin protein size on nuclear localization and cellular toxicity.

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https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900615-3

7 January 2021

Transgenic mice expressing a Huntington's disease mutation are resistant to quinolinic acid-induced striatal excitotoxicity

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https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900615-3

7 January 2021

Resistance to NMDA toxicity correlates with appearance of nuclear inclusions, behavioural deficits and changes in calcium homeostasis in mice transgenic for exon 1 of the huntington gene

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https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900615-3

7 January 2021

A primate model of Huntington's disease: behavioral and anatomical studies of unilateral excitotoxic lesions of the caudate-putamen in the baboon

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https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900615-3

7 January 2021

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

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https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900615-3

7 January 2021

A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration.

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https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900615-3

7 January 2021

Cloned glutamate receptors

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https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900615-3

7 January 2021

Muscarinic receptors modulate N-, P-, and L-type Ca2+ currents in rat striatal neurons through parallel pathways

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https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900615-3

7 January 2021

Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis.

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https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900615-3

7 January 2021

Cortical and striatal neuronal cultures of the same embryonic origin show intrinsic differences in glutamate receptor expression and vulnerability to excitotoxicity

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https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900615-3

7 January 2021

Localization of alternatively spliced NMDAR1 glutamate receptor isoforms in rat striatal neurons

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https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900615-3

7 January 2021

Changes in cortical and striatal neurons predict behavioral and electrophysiological abnormalities in a transgenic murine model of Huntington's disease

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https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900615-3

7 January 2021

NMDA receptor subunit mRNA expression by projection neurons and interneurons in rat striatum.

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https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900615-3

7 January 2021

Cellular defects and altered gene expression in PC12 cells stably expressing mutant huntingtin

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https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900615-3

7 January 2021

Amino-terminal fragments of mutant huntingtin show selective accumulation in striatal neurons and synaptic toxicity

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https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900615-3

7 January 2021

Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

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https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900615-3

7 January 2021

Length of huntingtin and its polyglutamine tract influences localization and frequency of intracellular aggregates

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https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900615-3

7 January 2021

Duplication of biochemical changes of Huntington's chorea by intrastriatal injections of glutamic and kainic acids

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https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900615-3

7 January 2021

Developmental and regional expression in the rat brain and functional properties of four NMDA receptors

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https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900615-3

7 January 2021

Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease

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https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900615-3

7 January 2021

N-methyl-D-aspartate receptor proteins NR2A and NR2B are differentially distributed in the developing rat central nervous system as revealed by subunit-specific antibodies.

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https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900615-3

7 January 2021

Caspase-8 is required for cell death induced by expanded polyglutamine repeats.

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https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900615-3

7 January 2021

Axonal transport of N-terminal huntingtin suggests early pathology of corticostriatal projections in Huntington disease

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https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900615-3

7 January 2021

Activation and desensitization of N-methyl-D-aspartate receptors in nucleated outside-out patches from mouse neurones

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https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900615-3

7 January 2021

Postsynaptic organization and regulation of excitatory synapses

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https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900615-3

7 January 2021

Fluoro-Jade: a novel fluorochrome for the sensitive and reliable histochemical localization of neuronal degeneration

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900615-3

7 January 2021

Polyglutamine-expanded huntingtin promotes sensitization of N-methyl-D-aspartate receptors via post-synaptic density 95.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900615-3

7 January 2021

Immunohistochemical localization of N-methyl-D-aspartate receptor NR1, NR2A, NR2B and NR2C/D subunits in the adult mammalian cerebellum

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900615-3

7 January 2021

Huntington's disease: the challenge for cell biologists

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https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900615-3

7 January 2021

The pathways of cell death: oncosis, apoptosis, and necrosis

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900615-3

7 January 2021

Neuronal activity differentially regulates NMDA receptor subunit expression in cerebellar granule cells

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https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900615-3

7 January 2021

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900615-3

1 reference

7 January 2021

Phosphorylation and modulation of a kainate receptor (GluR6) by cAMP-dependent protein kinase

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https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900615-3

7 January 2021

Modulation of AMPA/kainate receptors in cultured murine hippocampal neurones by protein kinase C.

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https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900615-3

7 January 2021

Caspases and neurodegeneration: on the cutting edge of new therapeutic approaches.

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https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900615-3

7 January 2021

Inhibiting caspase cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and nonneuronal cells

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https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900615-3

7 January 2021

Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900615-3

7 January 2021

NMDA receptor losses in putamen from patients with Huntington's disease

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https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900615-3

7 January 2021

Mutant huntingtin enhances excitotoxic cell death.

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https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2900615-3

7 January 2021

10.1016/S0896-6273(02)00615-3

Identifiers

DOI

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28 November 2017

1 reference

PubMed ID

11906693