Serine 577 is phosphorylated and negatively affects the tRNA binding and eIF2alpha kinase activities of GCN2. (Q44031815)

29 November 2017

Serine 577 is phosphorylated and negatively affects the tRNA binding and eIF2alpha kinase activities of GCN2. (English)

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29 November 2017

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Minerva Garcia-Barrio

1

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29 November 2017

Jinsheng Dong

2

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29 November 2017

Vera A Cherkasova

3

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29 November 2017

Xiaolong Zhang

4

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29 November 2017

Fan Zhang

5

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29 November 2017

Sandra Ufano

6

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29 November 2017

Ruby Lai

7

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29 November 2017

Jun Qin

8

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29 November 2017

Alan G Hinnebusch

9

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29 November 2017

language of work or name

English

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publication date

17 June 2002

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Journal of Biological Chemistry

29 November 2017

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29 November 2017

277

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29 November 2017

34

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29 November 2017

30675-30683

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MAP kinase pathways in yeast: for mating and more

29 November 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203187200

Molecular cloning and mapping of the brain-abundant B1gamma subunit of protein phosphatase 2A, PPP2R2C, to human chromosome 4p16

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203187200

Transcriptional profiling shows that Gcn4p is a master regulator of gene expression during amino acid starvation in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203187200

Translation of the yeast transcriptional activator GCN4 is stimulated by purine limitation: implications for activation of the protein kinase GCN2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203187200

Glucose limitation induces GCN4 translation by activation of Gcn2 protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203187200

The protein kinase Gcn2p mediates sodium toxicity in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203187200

The histidyl-tRNA synthetase-related sequence in the eIF-2 alpha protein kinase GCN2 interacts with tRNA and is required for activation in response to starvation for different amino acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203187200

Histidyl-tRNA synthetase-related sequences in GCN2 protein kinase regulate in vitro phosphorylation of eIF-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203187200

Uncharged tRNA activates GCN2 by displacing the protein kinase moiety from a bipartite tRNA-binding domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203187200

Characterization of the hemin-sensitive eukaryotic initiation factor 2alpha kinase from mouse nonerythroid cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203187200

Regulated translation initiation controls stress-induced gene expression in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203187200

Dimerization by translation initiation factor 2 kinase GCN2 is mediated by interactions in the C-terminal ribosome-binding region and the protein kinase domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203187200

The tRNA-binding moiety in GCN2 contains a dimerization domain that interacts with the kinase domain and is required for tRNA binding and kinase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203187200

Ribosome association of GCN2 protein kinase, a translational activator of the GCN4 gene of Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203187200

Ribosome-binding domain of eukaryotic initiation factor-2 kinase GCN2 facilitates translation control

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203187200

Juxtaposition of domains homologous to protein kinases and histidyl-tRNA synthetases in GCN2 protein suggests a mechanism for coupling GCN4 expression to amino acid availability

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203187200

Association of GCN1-GCN20 regulatory complex with the N-terminus of eIF2alpha kinase GCN2 is required for GCN2 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203187200

Separate domains in GCN1 for binding protein kinase GCN2 and ribosomes are required for GCN2 activation in amino acid-starved cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203187200

Budding yeast GCN1 binds the GI domain to activate the eIF2alpha kinase GCN2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203187200

GCN1, a translational activator of GCN4 in Saccharomyces cerevisiae, is required for phosphorylation of eukaryotic translation initiation factor 2 by protein kinase GCN2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203187200

Evidence that GCN1 and GCN20, translational regulators of GCN4, function on elongating ribosomes in activation of eIF2alpha kinase GCN2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203187200

Mutations activating the yeast eIF-2 alpha kinase GCN2: isolation of alleles altering the domain related to histidyl-tRNA synthetases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203187200

Atomic structure of the MAP kinase ERK2 at 2.3 A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203187200

Crystal structure of cyclin-dependent kinase 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203187200

Phosphorylation modulates catalytic function and regulation in the cAMP-dependent protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203187200

Active and inactive protein kinases: structural basis for regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203187200

Autophosphorylation in the activation loop is required for full kinase activity in vivo of human and yeast eukaryotic initiation factor 2alpha kinases PKR and GCN2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203187200

Identification of positive-acting domains in GCN2 protein kinase required for translational activation of GCN4 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203187200

Effect of brain ischemia and reperfusion on the localization of phosphorylated eukaryotic initiation factor 2 alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203187200

Yeast translation initiation suppressor sui2 encodes the alpha subunit of eukaryotic initiation factor 2 and shares sequence identity with the human alpha subunit.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203187200

Identification of phosphorylation sites in proteins separated by polyacrylamide gel electrophoresis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203187200

Association of RAP1 binding sites with stringent control of ribosomal protein gene transcription in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203187200

Phosphorylation of initiation factor 2 alpha by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203187200

Homologous segments in three subunits of the guanine nucleotide exchange factor eIF2B mediate translational regulation by phosphorylation of eIF2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203187200

Vector systems for the expression, analysis and cloning of DNA sequences in S. cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203187200

Mutations that bypass tRNA binding activate the intrinsically defective kinase domain in GCN2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203187200

Genetic and biochemical evidence for yeast GCN2 protein kinase polymerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203187200

Coupling of GCN4 mRNA translational activation with decreased rates of polypeptide chain initiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203187200

21 January 2018

Identifiers

DOI

10.1074/JBC.M203187200

1 reference

29 November 2017

1 reference