Carcinogen-induced pancreatic lesions in the mouse: effect of Smad4 and Apc genotypes (Q44049470)

29 November 2017

Carcinogen-induced pancreatic lesions in the mouse: effect of Smad4 and Apc genotypes (English)

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29 November 2017

7

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29 November 2017

John O Mason

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author name string

Jan Cullingworth

1

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29 November 2017

Martin L Hooper

2

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29 November 2017

David J Harrison

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29 November 2017

Christian Sirard

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29 November 2017

Charles E Patek

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29 November 2017

language of work or name

English

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publication date

1 July 2002

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29 November 2017

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29 November 2017

21

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29 November 2017

4696-4701

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29 November 2017

30

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1205673

29 November 2017

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Genetic and immunohistochemical analysis of pancreatic acinar cell carcinoma: frequent allelic loss on chromosome 11p and alterations in the APC/beta-catenin pathway

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Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes

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Induction of apoptosis by DPC4, a transcriptional factor regulated by transforming growth factor-beta through stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) signaling pathway

21 January 2018

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Expression of a dominant-negative mutant TGF-beta type II receptor in transgenic mice reveals essential roles for TGF-beta in regulation of growth and differentiation in the exocrine pancreas

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Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma

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The molecular genetics of pancreatic cancer

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Role of transforming growth factor-beta signaling in cancer

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Differential expression of surface markers on thymic lymphomas induced by two carcinogenic agents in different mouse strains.

21 January 2018

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Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation

21 January 2018

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Identification and characterization of the familial adenomatous polyposis coli gene

21 January 2018

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DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1

21 January 2018

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Identification of c-MYC as a target of the APC pathway

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TGF-beta signalling from cell membrane to nucleus through SMAD proteins

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Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

21 January 2018

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Incidence of p53 and Ha-ras gene mutations in chemically induced rat mammary carcinomas.

21 January 2018

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Dysregulated expression of beta-catenin marks early neoplastic change in Apc mutant mice, but not all lesions arising in Msh2 deficient mice.

21 January 2018

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Association of Smads with lymphoid enhancer binding factor 1/T cell-specific factor mediates cooperative signaling by the transforming growth factor-beta and wnt pathways

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Tumor suppressor activity of the TGF-beta pathway in human cancers

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A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse

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Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein

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Interaction between Wnt and TGF-beta signalling pathways during formation of Spemann's organizer.

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The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo

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Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes

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Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells

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Haploid loss of the tumor suppressor Smad4/Dpc4 initiates gastric polyposis and cancer in mice.

21 January 2018

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The tumor suppressor SMAD4/DPC4 is essential for epiblast proliferation and mesoderm induction in mice

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DNA cytofluorometric and nuclear morphometric analyses of lung adenocarcinoma

21 January 2018

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7 January 2021

Recent discoveries in cancer genetics of exocrine pancreatic neoplasia

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Analysis of cell ploidy in histological sections of mouse tissues by DNA-DNA in situ hybridization with digoxigenin-labelled probes

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Interphase and metaphase resolution of different distances within the human dystrophin gene

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Higher frequency of Smad4 gene mutation in human colorectal cancer with distant metastasis

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The adenomatous polyposis coli (APC) tumor suppressor

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Identifiers

DOI

10.1038/SJ.ONC.1205673

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Dimensions Publication ID

29 November 2017

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