Reduced (+/-)-3,4-methylenedioxymethamphetamine ("Ecstasy") metabolism with cytochrome P450 2D6 inhibitors and pharmacogenetic variants in vitro. (Q44057989)

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English	Reduced (+/-)-3,4-methylenedioxymethamphetamine ("Ecstasy") metabolism with cytochrome P450 2D6 inhibitors and pharmacogenetic variants in vitro.	scientific article

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10 November 2019

Reduced (+/-)-3,4-methylenedioxymethamphetamine ("Ecstasy") metabolism with cytochrome P450 2D6 inhibitors and pharmacogenetic variants in vitro (English)

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Europe PubMed Central

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10 November 2019

Edward M. Sellers

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10 November 2019

Rachel F Tyndale

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10 November 2019

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Yamini Ramamoorthy

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10 November 2019

Ai-ming Yu

2

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10 November 2019

Nina Suh

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10 November 2019

Robert L Haining

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10 November 2019

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1 June 2002

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10 November 2019

Biochemical Pharmacology

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10 November 2019

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10 November 2019

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10 November 2019

2111-2119

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10 November 2019

Acute and subchronic effects of methylenedioxymethamphetamine [(+/-)MDMA] on locomotion and serotonin syndrome behavior in the rat

1 reference

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7 January 2021

Toxicity and deaths from 3,4-methylenedioxymethamphetamine ("ecstasy")

1 reference

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7 January 2021

Low-dose MDMA ("ecstasy") induces vasopressin secretion

1 reference

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7 January 2021

Acute Toxicity of 3,4-Methylenedioxymethamphetamine (MDMA) in Sprague–Dawley and Dark Agouti Rats

1 reference

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7 January 2021

Positron emission tomographic evidence of toxic effect of MDMA ("Ecstasy") on brain serotonin neurons in human beings

1 reference

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7 January 2021

Causes and consequences of the loss of serotonergic presynapses elicited by the consumption of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") and its congeners

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Defective N-oxidation of sparteine in man: A new pharmacogenetic defect

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7 January 2021

Polymorphic hydroxylation of Debrisoquine in man.

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7 January 2021

Interactions of amphetamine analogs with human liver CYP2D6

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Pronounced differences between native Chinese and Swedish populations in the polymorphic hydroxylations of debrisoquin and S-mephenytoin

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7 January 2021

The decreased in vivo clearance of CYP2D6 substrates by CYP2D6*10 might be caused not only by the low-expression but also by low affinity of CYP2D6.

1 reference

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7 January 2021

A combination of mutations in the CYP2D6*17 (CYP2D6Z) allele causes alterations in enzyme function.

1 reference

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7 January 2021

A novel mutant variant of the CYP2D6 gene (CYP2D6*17) common in a black African population: association with diminished debrisoquine hydroxylase activity

1 reference

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7 January 2021

CYP2D6 polymorphism in a Gabonese population: contribution of the CYP2D6*2 and CYP2D6*17 alleles to the high prevalence of the intermediate metabolic phenotype

1 reference

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7 January 2021

Polymorphism of the cytochrome P450 CYP2D6 gene in a European population: characterization of 48 mutations and 53 alleles, their frequencies and evolution.

1 reference

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7 January 2021

Frequent occurrence of CYP2D6 gene duplication in Saudi Arabians

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7 January 2021

Identification of metabolites of 3,4-(methylenedioxy)methamphetamine in human urine

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7 January 2021

Identification of the human cytochromes P450 involved in the oxidative metabolism of "Ecstasy"-related designer drugs

1 reference

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7 January 2021

The demethylenation of methylenedioxymethamphetamine ("ecstasy") by debrisoquine hydroxylase (CYP2D6)

1 reference

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7 January 2021

Non-linear pharmacokinetics of MDMA ('ecstasy') in humans

1 reference

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7 January 2021

Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine

1 reference

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7 January 2021

Evaluation of atypical cytochrome P450 kinetics with two-substrate models: evidence that multiple substrates can simultaneously bind to cytochrome P450 active sites

1 reference

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7 January 2021

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10.1016/S0006-2952(02)01028-6

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12110370%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12110370%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

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