Substrate-dependent, non-hyperbolic kinetics of pig brain prolyl oligopeptidase and its tight binding inhibition by JTP-4819. (Q44082415)

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11 November 2019

title

Substrate-dependent, non-hyperbolic kinetics of pig brain prolyl oligopeptidase and its tight binding inhibition by JTP-4819 (English)

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11 November 2019

5

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11 November 2019

Markus M Forsberg

3

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11 November 2019

Arturo García-Horsman

4

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11 November 2019

Erik A A Wallén

6

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11 November 2019

Pekka T. Männistö

8

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11 November 2019

author name string

Jarkko I Venäläinen

1

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11 November 2019

Risto O Juvonen

2

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11 November 2019

Jukka Gynther

7

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11 November 2019

language of work or name

English

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publication date

1 August 2002

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11 November 2019

published in

Biochemical Pharmacology

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11 November 2019

volume

64

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11 November 2019

page(s)

463-471

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11 November 2019

issue

3

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Proline specific peptidases

11 November 2019

cites work

1 reference

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cDNA cloning of porcine brain prolyl endopeptidase and identification of the active-site seryl residue

7 January 2021

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In vitro and in vivo inhibition of prolyl endopeptidase

7 January 2021

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Effect of a novel prolyl endopeptidase inhibitor, JTP-4819, on spatial memory and central cholinergic neurons in aged rats.

7 January 2021

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Substrate- and pH-dependent contribution of oxyanion binding site to the catalysis of prolyl oligopeptidase, a paradigm of the serine oligopeptidase family

7 January 2021

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7 January 2021

Prolyl Oligopeptidase

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Structures of prolyl oligopeptidase substrate/inhibitor complexes. Use of inhibitor binding for titration of the catalytic histidine residue

7 January 2021

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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

7 January 2021

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Tight-binding inhibitors-I. Kinetic behavior

7 January 2021

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Automated docking using a Lamarckian genetic algorithm and an empirical binding free energy function

7 January 2021

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7 January 2021

Prolyl oligopeptidases

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pH-dependent mechanism in the catalysis of prolyl endopeptidase from pig muscle

7 January 2021

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Changes in Prolyl Endopeptidase During Maturation of Rat Brain and Hydrolysis of Substance P by the Purified Enzyme

7 January 2021

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Prolyl endopeptidase from bovine testis: purification, characterization and comparison with the enzymes from other tissues

7 January 2021

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Oligopeptidase B: a new type of serine peptidase with a unique substrate-dependent temperature sensitivity

7 January 2021

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A Novel Prolyl Endopeptidase Inhibitor, JTP-4819 - Its Behavioral and Neurochemical Properties for the Treatment of Alzheimer's Disease

7 January 2021

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Slow tight-binding inhibition of prolyl endopeptidase by benzyloxycarbonyl-prolyl-prolinal

7 January 2021

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Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

7 January 2021

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10.1016/S0006-2952(02)01184-X

7 January 2021

Identifiers

DOI

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11 November 2019

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