Leucine is a direct-acting nutrient signal that regulates protein synthesis in adipose tissue (Q44095707)

29 November 2017

Leucine is a direct-acting nutrient signal that regulates protein synthesis in adipose tissue (English)

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29 November 2017

Christopher J Lynch

1

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29 November 2017

Brian J Patson

2

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29 November 2017

Joshua Anthony

3

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29 November 2017

Alain Vaval

4

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29 November 2017

Leonard S Jefferson

5

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29 November 2017

Thomas C Vary

6

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29 November 2017

1 September 2002

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American Journal of Physiology - Endocrinology and Metabolism

29 November 2017

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29 November 2017

283

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29 November 2017

E503-13

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29 November 2017

3

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Stimulaiton of insulin biosynthesis in isolated mouse islets by L-leucine, 2-aminonorbornane-2-carboxylic acid and alpha-ketoisocaproic acid

29 November 2017

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00084.2002

Amino acids and insulin are both required to regulate assembly of the eIF4E. eIF4G complex in rat skeletal muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00084.2002

The effects of halothane (2-bromo-2-chloro-1,1,1-trifluoroethane) on glycolysis and biosynthetic processes of the isolated perfused rat liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00084.2002

Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00084.2002

Leucine. A possible regulator of protein turnover in muscle

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00084.2002

Studies concerning the specificity of the effect of leucine on the turnover of proteins in muscles of control and diabetic rats

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00084.2002

Target of rapamycin (TOR): balancing the opposing forces of protein synthesis and degradation

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00084.2002

Mammalian TOR: a homeostatic ATP sensor

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00084.2002

Ribosomal S6 kinase signaling and the control of translation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00084.2002

Plasma Amino Acid Levels and Insulin Secretion in Obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00084.2002

Availability of eIF4E regulates skeletal muscle protein synthesis during recovery from exercise.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00084.2002

4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00084.2002

Regulation of translation initiation by FRAP/mTOR

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00084.2002

The effects of glucose and cyclic GMP on RNA synthesis and nuclear morphology in starved rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00084.2002

Human Maternal and Fetal Serum Insulin and Growth Hormone (HGH) Response to Glucose and Leucine

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00084.2002

Physiological covalent regulation of rat liver branched-chain alpha-ketoacid dehydrogenase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00084.2002

Distinct signalling pathways mediate insulin and phorbol ester-stimulated eukaryotic initiation factor 4F assembly and protein synthesis in HEK 293 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00084.2002

Immunopurified mammalian target of rapamycin phosphorylates and activates p70 S6 kinase alpha in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00084.2002

Leucine regulates translation of specific mRNAs in L6 myoblasts through mTOR-mediated changes in availability of eIF4E and phosphorylation of ribosomal protein S6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00084.2002

PHAS proteins as mediators of the actions of insulin, growth factors and cAMP on protein synthesis and cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00084.2002

Zinc stimulates the activity of the insulin- and nutrient-regulated protein kinase mTOR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00084.2002

Secretagogues modulate the calcium concentration in the endoplasmic reticulum of insulin-secreting cells. Studies in aequorin-expressing intact and permeabilized ins-1 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00084.2002

Branched-chain amino and keto acid metabolism in pancreatic islets

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00084.2002

Synthesis of the translational apparatus is regulated at the translational level

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00084.2002

Leucine-specific binding of photoreactive Leu7-MAP to a high molecular weight protein on the plasma membrane of the isolated rat hepatocyte.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00084.2002

Plasma free fatty acid concentrations in obesity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00084.2002

Bidirectional modulation of insulin action by amino acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00084.2002

Assessment of cell-signaling pathways in the regulation of mammalian target of rapamycin (mTOR) by amino acids in rat adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00084.2002

The target of rapamycin (TOR) proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00084.2002

The TOR kinases link nutrient sensing to cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00084.2002

Rapamycin in transplantation: a review of the evidence

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00084.2002

TOR, a central controller of cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00084.2002

Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00084.2002

4E-BP1 and S6K1: translational integration sites for nutritional and hormonal information in muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00084.2002

Branched-chain amino acid oxidation by isolated rat tissue preparations

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00084.2002

Amino acid-induced translation of TOP mRNAs is fully dependent on phosphatidylinositol 3-kinase-mediated signaling, is partially inhibited by rapamycin, and is independent of S6K1 and rpS6 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00084.2002

Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00084.2002

Tissue distribution, genomic structure, and chromosome mapping of mouse and human eukaryotic initiation factor 4E-binding proteins 1 and 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00084.2002

Amino acid-induced stimulation of translation initiation in rat skeletal muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00084.2002

Effects of chronic alcohol consumption on regulation of myocardial protein synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00084.2002

Multiphasic control of proteolysis by leucine and alanine in the isolated rat hepatocyte.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00084.2002

Multiple independent inputs are required for activation of the p70 S6 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00084.2002

Regulation of the p70 S6 kinase by phosphorylation in vivo. Analysis using site-specific anti-phosphopeptide antibodies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00084.2002

Metabolic regulation by leucine of translation initiation through the mTOR-signaling pathway by pancreatic beta-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00084.2002

Insulin mediates glucose-stimulated phosphorylation of PHAS-I by pancreatic beta cells. An insulin-receptor mechanism for autoregulation of protein synthesis by translation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00084.2002

Evidence That 3-Phosphoinositide-dependent Protein Kinase-1 Mediates Phosphorylation of p70 S6 Kinasein Vivoat Thr-412 as well as Thr-252

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00084.2002

10.1152/AJPENDO.00084.2002

21 January 2018

Identifiers

DOI

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29 November 2017

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