Constitutively active Akt is an important regulator of TRAIL sensitivity in prostate cancer (Q43761459)

26 November 2017

Constitutively active Akt is an important regulator of TRAIL sensitivity in prostate cancer (English)

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26 November 2017

X Chen

1

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26 November 2017

H Thakkar

2

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26 November 2017

F Tyan

3

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26 November 2017

S Gim

4

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26 November 2017

H Robinson

5

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26 November 2017

C Lee

6

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26 November 2017

S K Pandey

7

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26 November 2017

C Nwokorie

8

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26 November 2017

N Onwudiwe

9

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26 November 2017

R K Srivastava

10

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26 November 2017

language of work or name

English

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publication date

1 September 2001

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26 November 2017

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26 November 2017

20

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26 November 2017

42

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26 November 2017

6073-6083

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1204736

26 November 2017

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TRAIL receptor-2 signals apoptosis through FADD and caspase-8

21 January 2018

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Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

21 January 2018

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Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a)

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New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

21 January 2018

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Regulation of cell death protease caspase-9 by phosphorylation

21 January 2018

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Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

21 January 2018

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Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

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Pten is essential for embryonic development and tumour suppression

21 January 2018

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Mechanisms and consequences of activation of protein kinase B/Akt

21 January 2018

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Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

21 January 2018

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The TRAIL to selective tumor death

21 January 2018

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Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain

21 January 2018

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Mitochondria and apoptosis

21 January 2018

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Monocyte-mediated tumoricidal activity via the tumor necrosis factor-related cytokine, TRAIL.

21 January 2018

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Akt signaling: linking membrane events to life and death decisions

21 January 2018

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The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB.

21 January 2018

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Akt/Protein kinase B inhibits cell death by preventing the release of cytochrome c from mitochondria

21 January 2018

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Apo2L/TRAIL-dependent recruitment of endogenous FADD and caspase-8 to death receptors 4 and 5.

21 January 2018

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Cytochrome c activation of CPP32-like proteolysis plays a critical role in a Xenopus cell-free apoptosis system.

21 January 2018

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Inactivation of the PTEN/MMAC1/TEP1 gene in human lung cancers.

21 January 2018

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PTEN1 is frequently mutated in primary endometrial carcinomas

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Forkhead transcription factors: new insights into protein kinase B (c-akt) signaling.

21 January 2018

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Death and survival signals determine active/inactive conformations of pro-apoptotic BAX, BAD, and BID molecules

21 January 2018

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Mitochondrial control of cell death

21 January 2018

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Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt.

21 January 2018

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21 January 2018

Cancer statistics, 1999.

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PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

21 January 2018

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Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome

21 January 2018

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Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

21 January 2018

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Integrin-linked kinase regulates phosphorylation of serine 473 of protein kinase B by an indirect mechanism

21 January 2018

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AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

21 January 2018

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Apoptosis by death factor

21 January 2018

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Elevated AKT activity protects the prostate cancer cell line LNCaP from TRAIL-induced apoptosis

21 January 2018

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Structure and function of Fas/Fas ligand

21 January 2018

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The receptor for the cytotoxic ligand TRAIL

21 January 2018

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Chemotherapy for advanced hormone refractory prostate cancer

21 January 2018

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Anti-androgens and other hormonal therapies for prostate cancer

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204736

Human astrocytic brain tumors express AP02L/TRAIL.

21 January 2018

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Two CD95 (APO-1/Fas) signaling pathways

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204736

Characterization of two receptors for TRAIL

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204736

TRICK2, a new alternatively spliced receptor that transduces the cytotoxic signal from TRAIL

21 January 2018

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Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors

21 January 2018

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FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2

21 January 2018

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Intracellular mechanisms of TRAIL and its role in cancer therapy

21 January 2018

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Bcl-2-mediated drug resistance: inhibition of apoptosis by blocking nuclear factor of activated T lymphocytes (NFAT)-induced Fas ligand transcription

21 January 2018

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Bcl-2 and Bcl-X(L) block thapsigargin-induced nitric oxide generation, c-Jun NH(2)-terminal kinase activity, and apoptosis

21 January 2018

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Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

21 January 2018

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Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

21 January 2018

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Intracellular mechanisms of TRAIL: apoptosis through mitochondrial-dependent and -independent pathways

21 January 2018

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Molecular characterization of mitochondrial apoptosis-inducing factor

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204736

Negative regulation of the forkhead transcription factor FKHR by Akt.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204736

Structural assets of a tumor suppressor.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204736

Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins

21 January 2018

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Inhibition of death receptor-mediated gene induction by a cycloheximide-sensitive factor occurs at the level of or upstream of Fas-associated death domain protein (FADD)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204736

TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204736

Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204736

PTEN inhibits insulin-stimulated MEK/MAPK activation and cell growth by blocking IRS-1 phosphorylation and IRS-1/Grb-2/Sos complex formation in a breast cancer model

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204736

Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204736

KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204736

The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204736

Signalling by proteolysis: death receptors induce apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204736

The point of no return: mitochondria, caspases, and the commitment to cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204736

7 January 2021

TRAIL: a molecule with multiple receptors and control mechanisms

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204736

7 January 2021

How TRAIL kills cancer cells, but not normal cells

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204736

7 January 2021

Failure of Bcl-2 to block cytochrome c redistribution during TRAIL-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204736

7 January 2021

Activity of TNF-related apoptosis-inducing ligand (TRAIL) in haematological malignancies

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204736

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1204736

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Dimensions Publication ID

26 November 2017

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