Leptin expression in hypothalamic PVN reverses dietary obesity and hyperinsulinemia but stimulates ghrelin (Q44196009)

30 November 2017

title

Leptin expression in hypothalamic PVN reverses dietary obesity and hyperinsulinemia but stimulates ghrelin (English)

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30 November 2017

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Michela Bagnasco

1

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30 November 2017

Michael G Dube

2

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30 November 2017

Adi Katz

3

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30 November 2017

Pushpa S Kalra

4

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30 November 2017

Satya P Kalra

5

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30 November 2017

publication date

1 December 2003

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30 November 2017

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30 November 2017

volume

11

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30 November 2017

issue

12

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30 November 2017

page(s)

1463-1470

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Obesity and the regulation of energy balance

30 November 2017

cites work

1 reference

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Leptin regulation of neuroendocrine systems

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Serum immunoreactive-leptin concentrations in normal-weight and obese humans

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Dynamic regulation of leptin entry into brain by the blood-brain barrier

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Obesity is associated with a decreased leptin transport across the blood-brain barrier in rats

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Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity

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Central leptin gene therapy suppresses body weight gain, adiposity and serum insulin without affecting food consumption in normal rats: a long-term study

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Dose-dependent effects of central leptin gene therapy on genes that regulate body weight and appetite in the hypothalamus

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Long-term suppression of weight gain, adiposity, and serum insulin by central leptin gene therapy in prepubertal rats: effects on serum ghrelin and appetite-regulating genes

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Evidence for the existence of distinct central appetite, energy expenditure, and ghrelin stimulation pathways as revealed by hypothalamic site-specific leptin gene therapy

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Central leptin gene therapy blocks high-fat diet-induced weight gain, hyperleptinemia, and hyperinsulinemia: increase in serum ghrelin levels

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Leptin receptors in estrogen receptor-containing neurons of the female rat hypothalamus

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Localization of leptin receptor mRNA and the long form splice variant (Ob-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization

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Unraveling the central nervous system pathways underlying responses to leptin

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The long form of the leptin receptor (OB-Rb) is widely expressed in the human brain

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Neural substrates for leptin and neuropeptide Y (NPY) interaction: hypothalamic sites associated with inhibition of NPY-induced food intake

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A war on obesity, not the obese

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Effects of the obese gene product on body weight regulation in ob/ob mice

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Long-term differential modulation of genes encoding orexigenic and anorexigenic peptides by leptin delivered by rAAV vector in ob/ob mice. Relationship with body weight change

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Leptin gene expression in the brain and pituitary gland

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Evidence that the caudal brainstem is a target for the inhibitory effect of leptin on food intake

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Brain stem is a direct target for leptin's action in the central nervous system

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Neuropeptide Y (NPY) Y1 receptor mRNA is upregulated in association with transient hyperphagia and body weight gain: evidence for a hypothalamic site for concurrent development of leptin resistance

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Disruption in neuropeptide Y and leptin signaling in obese ventromedial hypothalamic-lesioned rats

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Resistance to adenovirally induced hyperleptinemia in rats. Comparison of ventromedial hypothalamic lesions and mutated leptin receptors

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Viral vectors for gene therapy: the art of turning infectious agents into vehicles of therapeutics

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Real-time single-molecule imaging of the infection pathway of an adeno-associated virus

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Obesity and insulin resistance

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Ghrelin induces adiposity in rodents

21 January 2018

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Neuroendocrine and peripheral activities of ghrelin: implications in metabolism and obesity

21 January 2018

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The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis

21 January 2018

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Obesity and the environment: where do we go from here?

21 January 2018

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A clinical view of the obesity problem

31 March 2020

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https://api.crossref.org/works/10.1038%2FOBY.2003.196

Regulation of leptin secretion: effects of aging on daily patterns of serum leptin and food consumption

31 March 2020

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https://api.crossref.org/works/10.1038%2FOBY.2003.196

Impaired transport of leptin across the blood-brain barrier in obesity

31 March 2020

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Leptin receptor immunoreactivity in chemically defined target neurons of the hypothalamus

31 March 2020

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Towards a molecular understanding of adaptive thermogenesis

31 March 2020

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Neuropeptide Y injection into the fourth cerebroventricle stimulates c-Fos expression in the paraventricular nucleus and other nuclei in the forebrain: effect of food consumption

31 March 2020

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https://api.crossref.org/works/10.1038%2FOBY.2003.196

c-fos expression in the rat brain following central administration of neuropeptide Y and effects of food consumption

31 March 2020

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https://api.crossref.org/works/10.1038%2FOBY.2003.196

The adipoinsular axis: effects of leptin on pancreatic beta-cells

31 March 2020

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https://api.crossref.org/works/10.1038%2FOBY.2003.196

Minireview: ghrelin and the regulation of energy balance--a hypothalamic perspective

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.196

31 March 2020

Identifiers

DOI

10.1038/OBY.2003.196

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30 November 2017

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