Insulin modulates PC-1 processing and recruitment in cultured human cells (Q44222467)

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title

Insulin modulates PC-1 processing and recruitment in cultured human cells (English)

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1

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Di Paola R

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Baj G

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Funaro A

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Arnulfo A

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Ercolino T

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Surico N

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Malavasi F

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Trischitta V

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publication date

19 November 2002

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American Journal of Physiology - Endocrinology and Metabolism

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published in

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volume

284

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issue

3

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page(s)

E514-20

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Metabolic and genetic characterization of prediabetic states. Sequence of events leading to non-insulin-dependent diabetes mellitus

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Divalent cations stabilize the conformation of plasma cell membrane glycoprotein PC-1 (alkaline phosphodiesterase I).

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Nucleotide pyrophosphatases/phosphodiesterases on the move

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The Q allele variant (GLN121) of membrane glycoprotein PC-1 interacts with the insulin receptor and inhibits insulin signaling more effectively than the common K allele variant (LYS121)

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A cluster of three single nucleotide polymorphisms in the 3'-untranslated region of human glycoprotein PC-1 gene stabilizes PC-1 mRNA and is associated with increased PC-1 protein content and insulin resistance-related abnormalities

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High insulin levels do not influence PC-1 gene expression and protein content in human muscle tissue and hepatoma cells.

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Elevated PC-1 content in cultured skin fibroblasts correlates with decreased in vivo and in vitro insulin action in nondiabetic subjects: evidence that PC-1 may be an intrinsic factor in impaired insulin receptor signaling

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Increased adipose tissue PC-1 protein content, but not tumour necrosis factor-alpha gene expression, is associated with a reduction of both whole body insulin sensitivity and insulin receptor tyrosine-kinase activity.

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Expression of the nucleoside triphosphate pyrophosphohydrolase PC-1 is induced by basic fibroblast growth factor (bFGF) and modulated by activation of the protein kinase A and C pathways in osteoblast-like osteosarcoma cells

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21 January 2018

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Phosphatidylinositol 3-kinase acts at an intracellular membrane site to enhance GLUT4 exocytosis in 3T3-L1 cells

21 January 2018

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Identifiers

DOI

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1 December 2017

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