Residues glutamate 216 and aspartate 301 are key determinants of substrate specificity and product regioselectivity in cytochrome P450 2D6. (Q44226094)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12446689%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

title

Residues glutamate 216 and aspartate 301 are key determinants of substrate specificity and product regioselectivity in cytochrome P450 2D6 (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12446689%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12446689%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

Mark John Ingraham Paine

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12446689%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

Mike Sutcliffe

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12446689%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

author name string

Lesley A McLaughlin

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12446689%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

Jack U Flanagan

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12446689%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

Carol A Kemp

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12446689%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

C Roland Wolf

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12446689%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

language of work or name

English

0 references

publication date

22 November 2002

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12446689%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

15 December 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12446689%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

volume

278

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12446689%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

issue

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12446689%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

page(s)

4021-4027

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12446689%20AND%20SRC:MED&resulttype=core&format=json

Polymorphic hydroxylation of Debrisoquine in man.

15 December 2019

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209519200

Defective N-oxidation of sparteine in man: A new pharmacogenetic defect

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209519200

Contribution of human hepatic cytochrome P450 isoforms to regioselective hydroxylation of steroid hormones

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209519200

Diversity in the oxidation of substrates by cytochrome P450 2D6: lack of an obligatory role of aspartate 301-substrate electrostatic bonding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209519200

Atypical metabolism of deprenyl and its enantiomer, (S)-(+)-N,alpha-dimethyl-N-propynylphenethylamine, by cytochrome P450 2D6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209519200

Cytochromes P450 mediating the N-demethylation of amitriptyline

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209519200

A three-dimensional molecular template for substrates of human cytochrome P450 involved in debrisoquine 4-hydroxylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209519200

Evidence that aspartic acid 301 is a critical substrate-contact residue in the active site of cytochrome P450 2D6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209519200

A model for human cytochrome P450 2D6 based on homology modeling and NMR studies of substrate binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209519200

Active-site topologies of human CYP2D6 and its aspartate-301 --> glutamate, asparagine, and glycine mutants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209519200

Heterologous expression of cytochrome P450 2D6 mutants, electron transfer, and catalysis of bufuralol hydroxylation: the role of aspartate 301 in structural integrity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209519200

Impact of incorporating the 2C5 crystal structure into comparative models of cytochrome P450 2D6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209519200

Determinants of the substrate specificity of human cytochrome P-450 CYP2D6: design and construction of a mutant with testosterone hydroxylase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209519200

A general strategy for the expression of recombinant human cytochrome P450s in Escherichia coli using bacterial signal peptides: expression of CYP3A4, CYP2A6, and CYP2E1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209519200

Rapid and efficient site-specific mutagenesis without phenotypic selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209519200

7 Purification and properties of NADPH-Cytochrome P-450 reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209519200

Comparative protein modelling by satisfaction of spatial restraints

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209519200

Development and validation of a genetic algorithm for flexible docking

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209519200

Amino acid 305 determines catalytic center accessibility in CYP3A4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209519200

Cytochrome P450 2C9 polymorphisms: a comprehensive review of the in-vitro and human data.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209519200

Comparative studies on the catalytic roles of cytochrome P450 2C9 and its Cys- and Leu-variants in the oxidation of warfarin, flurbiprofen, and diclofenac by human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209519200

Diclofenac and Its Derivatives As Tools for Studying Human Cytochromes P450 Active Sites: Particular Efficiency and Regioselectivity of P450 2Cs

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209519200

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine as a Substrate of Cytochrome P450 2D6: Allosteric Effects of NADPH−Cytochrome P450 Reductase†

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209519200

Identification of the cytochrome P450 isoforms involved in the O-demethylation of 4-nitroanisole in human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209519200

A predictive model for substrates of cytochrome P450-debrisoquine (2D6)

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209519200

The association between polymorphisms in the cytochrome P-450 2D6 gene and Parkinson's disease: a case-control study and meta-analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209519200

Microsomal cytochrome P450 2C5: comparison to microbial P450s and unique features

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209519200

Functional co-expression of CYP2D6 and human NADPH-cytochrome P450 reductase in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209519200

Characterization of CYP2C19 and CYP2C9 from human liver: respective roles in microsomal tolbutamide, S-mephenytoin, and omeprazole hydroxylations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209519200

A novel approach to predicting P450 mediated drug metabolism. CYP2D6 catalyzed N-dealkylation reactions and qualitative metabolite predictions using a combined protein and pharmacophore model for CYP2D6

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209519200

Molecular modelling of cytochrome P4502D6 (CYP2D6) based on an alignment with CYP102: structural studies on specific CYP2D6 substrate metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209519200

The CYP2 family: models, mutants and interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209519200