Simple mono-derivatisation of the aryl moiety of D4A and DDA-based phosphoramidate prodrugs significantly enhances their anti-HIV potency in cell culture. (Q44303108)

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English	Simple mono-derivatisation of the aryl moiety of D4A and DDA-based phosphoramidate prodrugs significantly enhances their anti-HIV potency in cell culture.	scientific article

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10498207%20AND%20SRC:MED&resulttype=core&format=json

31 October 2019

Simple mono-derivatisation of the aryl moiety of D4A and DDA-based phosphoramidate prodrugs significantly enhances their anti-HIV potency in cell culture (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10498207%20AND%20SRC:MED&resulttype=core&format=json

31 October 2019

Carlo Ballatore

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10498207%20AND%20SRC:MED&resulttype=core&format=json

31 October 2019

2

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31 October 2019

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A Q Siddiqui

1

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31 October 2019

O Wedgwood

4

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31 October 2019

E De Clercq

5

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31 October 2019

J Balzarini

6

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31 October 2019

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1 September 1999

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31 October 2019

Bioorganic & Medicinal Chemistry Letters

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31 October 2019

9

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31 October 2019

17

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31 October 2019

2555-2560

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31 October 2019

Equal inhibition of the replication of human immunodeficiency virus in human T-cell culture by ddA bis(SATE)phosphotriester and 3'-azido-2',3'-dideoxythymidine

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2899%2900416-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Initial studies on the cellular pharmacology of 2',3'-dideoxyadenosine, an inhibitor of HTLV-III infectivity

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https://api.crossref.org/works/10.1016%2FS0960-894X%2899%2900416-3

7 January 2021

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Phosphoramidate derivatives of 2′,3′-didehydro-2′,3′-dideoxyadenosine [d4A] have markedly improved anti-HIV potency and selectivity

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https://api.crossref.org/works/10.1016%2FS0960-894X%2899%2900416-3

7 January 2021

based on heuristic

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Conversion of 2',3'-dideoxyadenosine (ddA) and 2',3'-didehydro-2',3'-dideoxyadenosine (d4A) to their corresponding aryloxyphosphoramidate derivatives markedly potentiates their activity against human immunodeficiency virus and hepatitis B virus.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2899%2900416-3

7 January 2021

based on heuristic

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Aryl phosphoramidate derivatives of d4T have improved anti-HIV efficacy in tissue culture and may act by the generation of a novel intracellular metabolite.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2899%2900416-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Lactate cannot substitute for alanine in d4T-based anti-HIV nucleotide prodrugs--despite efficient esterase-mediated hydrolysis.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2899%2900416-3

7 January 2021

based on heuristic

inferred from DOI database lookup

The presence of substituents on the aryl moiety of the aryl phosphoramidate derivative of d4T enhances anti-HIV efficacy in cell culture: A structure-activity relationship.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2899%2900416-3

7 January 2021

based on heuristic

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10.1016/S0960-894X(99)00416-3

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10498207%20AND%20SRC:MED&resulttype=core&format=json

31 October 2019

release_gwfxjnhntncddfexdz2wtz4joq

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24 November 2022

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PubMed publication ID

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10498207%20AND%20SRC:MED&resulttype=core&format=json

31 October 2019

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