Design, Synthesis and Biological Evaluation of Two Opioid Agonist and Cav 2.2 Blocker Multitarget Ligands (Q44348169)

2 December 2017

Design, Synthesis and Biological Evaluation of Two Opioid Agonist and Cav 2.2 Blocker Multitarget Ligands (English)

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2 December 2017

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11

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2 December 2017

Stefano Pieretti

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Irina Vetter

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Irina Vetter

10

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Adriano Mollica

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Adriano Mollica

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Reza Samavati

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object named as

Reza Samavati

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2 December 2017

Roberto Costante

2

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2 December 2017

Azzurra Stefanucci

4

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2 December 2017

Ferenc Zador

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2 December 2017

Anna Borsodi

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2 December 2017

8 December 2014

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Chemical Biology and Drug Design

2 December 2017

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2 December 2017

86

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2 December 2017

2

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2 December 2017

156-162

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Stimulating the development of mechanism-based, individualized pain therapies

2 December 2017

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https://api.crossref.org/works/10.1111%2FCBDD.12479

75 years of opioid research: the exciting but vain quest for the Holy Grail

21 January 2018

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https://api.crossref.org/works/10.1111%2FCBDD.12479

An evaluation of intrathecal ziconotide for the treatment of chronic pain

21 January 2018

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https://api.crossref.org/works/10.1111%2FCBDD.12479

Intrathecal ziconotide for refractory chronic pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.12479

Intrathecal ziconotide in the treatment of refractory pain in patients with cancer or AIDS: a randomized controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.12479

A randomized, double-blind, placebo-controlled study of intrathecal ziconotide in adults with severe chronic pain.

21 January 2018

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https://api.crossref.org/works/10.1111%2FCBDD.12479

Low molecular weight non-peptide mimics of omega-conotoxin GVIA.

21 January 2018

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https://api.crossref.org/works/10.1111%2FCBDD.12479

Synthesis and biological evaluation of nonpeptide mimetics of omega-conotoxin GVIA.

21 January 2018

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https://api.crossref.org/works/10.1111%2FCBDD.12479

Structure-function relationships of omega-conotoxin GVIA. Synthesis, structure, calcium channel binding, and functional assay of alanine-substituted analogues.

21 January 2018

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https://api.crossref.org/works/10.1111%2FCBDD.12479

Development of small molecules that mimic the binding of omega-conotoxins at the N-type voltage-gated calcium channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.12479

Intrathecal combination of ziconotide and morphine for refractory cancer pain: a rapidly acting and effective choice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.12479

From models to molecules: opioid receptor dimers, bivalent ligands, and selective opioid receptor probes

21 January 2018

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https://api.crossref.org/works/10.1111%2FCBDD.12479

Designing multiple ligands - medicinal chemistry strategies and challenges

21 January 2018

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https://api.crossref.org/works/10.1111%2FCBDD.12479

Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.12479

Novel peptide ligands with dual acting pharmacophores designed for the pathophysiology of neuropathic pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.12479

Structure-activity relationships of bifunctional cyclic disulfide peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.12479

Spinal or systemic TY005, a peptidic opioid agonist/neurokinin 1 antagonist, attenuates pain with reduced tolerance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.12479

Design of novel neurokinin 1 receptor antagonists based on conformationally constrained aromatic amino acids and discovery of a potent chimeric opioid agonist-neurokinin 1 receptor antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.12479

Potent analgesic activity of the enkephalin-like tetrapeptide H-Tyr-D-Ala-Gly-Phe-NH2

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.12479

Double-enkephalins--synthesis, activity on guinea-pig ileum, and analgesic effect

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.12479

Delta and kappa opiate receptors in primary astroglial cultures from rat cerebral cortex

21 January 2018

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https://api.crossref.org/works/10.1111%2FCBDD.12479

Development of novel enkephalin analogues that have enhanced opioid activities at both mu and delta opioid receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.12479

Design and synthesis of novel hydrazide-linked bifunctional peptides as delta/mu opioid receptor agonists and CCK-1/CCK-2 receptor antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.12479

Recent updates of N-type calcium channel blockers with therapeutic potential for neuropathic pain and stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.12479

Three-dimensional structure in solution of the calcium channel blocker omega-conotoxin MVIIA

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.12479

Biological active analogues of the opioid peptide biphalin: mixed α/β(3)-peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.12479

Antinociceptive profile of potent opioid peptide AM94, a fluorinated analogue of biphalin with non-hydrazine linker

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.12479

Hybrid peptides endomorphin-2/DAMGO: design, synthesis and biological evaluation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.12479

Novel omega-conotoxins from Conus catus discriminate among neuronal calcium channel subtypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.12479

Spinal antinociceptive effects of AA501, a novel chimeric peptide with opioid receptor agonist and tachykinin receptor antagonist moieties

21 January 2018

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https://api.crossref.org/works/10.1111%2FCBDD.12479

21 January 2018

Identifiers

DOI

10.1111/CBDD.12479

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2 December 2017

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