BMP2 exposure results in decreased PTEN protein degradation and increased PTEN levels (Q44350476)

2 December 2017

BMP2 exposure results in decreased PTEN protein degradation and increased PTEN levels. (English)

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2 December 2017

2

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2 December 2017

Kristin A Waite

1

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2 December 2017

1 March 2003

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2 December 2017

Human Molecular Genetics

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2 December 2017

12

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2 December 2017

6

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2 December 2017

679-684

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PTEN: a tumour suppressor that functions as a phospholipid phosphatase

2 December 2017

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https://api.crossref.org/works/10.1093%2FHMG%2FDDG069

P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG069

Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDG069

Gab1 acts as an adapter molecule linking the cytokine receptor gp130 to ERK mitogen-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG069

PTEN inhibits insulin-stimulated MEK/MAPK activation and cell growth by blocking IRS-1 phosphorylation and IRS-1/Grb-2/Sos complex formation in a breast cancer model

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG069

Tumor suppressor and anti-inflammatory actions of PPARgamma agonists are mediated via upregulation of PTEN.

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDG069

Regulation of PTEN transcription by p53

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDG069

The Egr-1 transcription factor directly activates PTEN during irradiation-induced signalling

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDG069

The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDG069

Phosphorylation of the PTEN tail regulates protein stability and function

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDG069

Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG069

Mutation spectrum and genotype-phenotype analyses in Cowden disease and Bannayan-Zonana syndrome, two hamartoma syndromes with germline PTEN mutation

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDG069

Germline mutations in PTEN are present in Bannayan-Zonana syndrome.

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDG069

PTEN mutation spectrum and genotype-phenotype correlations in Bannayan-Riley-Ruvalcaba syndrome suggest a single entity with Cowden syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG069

Germline and germline mosaic PTEN mutations associated with a Proteus-like syndrome of hemihypertrophy, lower limb asymmetry, arteriovenous malformations and lipomatosis

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDG069

Bone morphogenetic proteins: multifunctional regulators of vertebrate development

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDG069

Bone morphogenetic protein-2 induces cyclin kinase inhibitor p21 and hypophosphorylation of retinoblastoma protein in estradiol-treated MCF-7 human breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG069

Bone morphogenetic protein 2 (BMP-2) induces sequential changes of Id gene expression in the breast cancer cell line MCF-7.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG069

PTEN coordinates G(1) arrest by down-regulating cyclin D1 via its protein phosphatase activity and up-regulating p27 via its lipid phosphatase activity in a breast cancer model

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDG069

TGF-beta signalling from cell membrane to nucleus through SMAD proteins

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDG069

The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG069

Identification of p21 as a target of cycloheximide-mediated facilitation of CD95-mediated apoptosis in human malignant glioma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG069

Inhibition of H-Ras transformation by the PTEN/MMAC1/TEP1 tumor suppressor gene

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDG069

Tumor suppressor activity of the TGF-beta pathway in human cancers

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDG069

DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG069

Proteasomal degradation of Smad1 induced by bone morphogenetic proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG069

New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDG069

Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG069

Differential nuclear and cytoplasmic expression of PTEN in normal thyroid tissue, and benign and malignant epithelial thyroid tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG069

Immunohistochemical evidence of loss of PTEN expression in primary ductal adenocarcinomas of the breast

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDG069

Measurement of protein using bicinchoninic acid

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDG069

Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG069

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDG069

Localization of the gene for Cowden disease to chromosome 10q22–23

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG069

Association of germline mutation in the PTEN tumour suppressor gene and Proteus and Proteus-like syndromes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG069

Nuclear PTEN expression and clinicopathologic features in a population-based series of primary cutaneous melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG069

21 January 2018

Identifiers

DOI

10.1093/HMG/DDG069

1 reference

2 December 2017

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PubMed ID

12620973