In vitro ADME profiling using high-throughput rapidfire mass spectrometry: cytochrome p450 inhibition and metabolic stability assays (Q44356453)

2 December 2017

In vitro ADME profiling using high-throughput rapidfire mass spectrometry: cytochrome p450 inhibition and metabolic stability assays (English)

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2 December 2017

Xiang Wu

1

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2 December 2017

Jing Wang

2

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2 December 2017

Lory Tan

3

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2 December 2017

John Bui

4

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2 December 2017

Erik Gjerstad

5

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2 December 2017

Kirk McMillan

6

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2 December 2017

Wentao Zhang

7

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2 December 2017

29 March 2012

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Journal of Biomolecular Screening

2 December 2017

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2 December 2017

17

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2 December 2017

761-772

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2 December 2017

6

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Recent patterns of medication use in the ambulatory adult population of the United States: the Slone survey

2 December 2017

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Effects of voriconazole on tacrolimus metabolism in a kidney transplant recipient

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https://api.crossref.org/works/10.1177%2F1087057112441013

Cytochrome P450 inhibition using recombinant proteins and mass spectrometry/multiple reaction monitoring technology in a cassette incubation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112441013

Comparison of cytochrome P450 inhibition assays for drug discovery using human liver microsomes with LC-MS, rhCYP450 isozymes with fluorescence, and double cocktail with LC-MS.

21 January 2018

1 reference

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Development of a fluorescence-based, ultra high-throughput screening platform for nanoliter-scale cytochrome p450 microarrays

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1 reference

https://api.crossref.org/works/10.1177%2F1087057112441013

Evaluation of fluorescence- and mass spectrometry-based CYP inhibition assays for use in drug discovery

21 January 2018

1 reference

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In vitro assessment of cytochrome P450 inhibition: strategies for increasing LC/MS-based assay throughput using a one-point IC(50) method and multiplexing high-performance liquid chromatography.

21 January 2018

1 reference

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A rapid ultra-performance liquid chromatography/tandem mass spectrometric methodology for the in vitro analysis of Pooled and Cocktail cytochrome P450 assays

21 January 2018

1 reference

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High-throughput inhibition screening of major human cytochrome P450 enzymes using an in vitro cocktail and liquid chromatography-tandem mass spectrometry

21 January 2018

1 reference

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Development of an in vitro drug-drug interaction assay to simultaneously monitor five cytochrome P450 isoforms and performance assessment using drug library compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112441013

Evaluation of cytochrome P450 inhibition assays using human liver microsomes by a cassette analysis /LC-MS/MS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112441013

Applications of high-throughput ADME in drug discovery

21 January 2018

1 reference

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Determination of a 'GW cocktail' of cytochrome P450 probe substrates and their metabolites in plasma and urine using automated solid phase extraction and fast gradient liquid chromatography tandem mass spectrometry.

21 January 2018

1 reference

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Application of a rapid and integrated analysis system (RIAS) as a high-throughput processing tool for in vitro ADME samples by liquid chromatography/tandem mass spectrometry

21 January 2018

1 reference

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High-throughput analysis of in vitro cytochrome p450 inhibition samples using mass spectrometry coupled with an integrated liquid chromatography/autosampler system

21 January 2018

1 reference

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Development of a high-throughput online solid-phase extraction/tandem mass spectrometry method for cytochrome P450 inhibition screening

21 January 2018

1 reference

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Structural basis for ligand promiscuity in cytochrome P450 3A4.

21 January 2018

1 reference

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CYP3A4 drug interactions: correlation of 10 in vitro probe substrates

21 January 2018

1 reference

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Interspecies difference in liver-specific functions and biotransformation of testosterone of primary rat, porcine and human hepatocyte in an organotypical sandwich culture.

21 January 2018

1 reference

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Simultaneous determination of testosterone metabolites in liver microsomes using column-switching semi-microcolumn high-performance liquid chromatography

21 January 2018

1 reference

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Validation of higher-throughput high-performance liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry assays to conduct cytochrome P450s CYP2D6 and CYP3A4 enzyme inhibition studies in human liver microsomes

21 January 2018

1 reference

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In vitro interaction cocktail assay for nine major cytochrome P450 enzymes with 13 probe reactions and a single LC/MSMS run: analytical validation and testing with monoclonal anti-CYP antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057112441013

21 January 2018

Identifiers

DOI

10.1177/1087057112441013

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2 December 2017

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