Presenilin-dependent gamma-secretase activity mediates the intramembranous cleavage of CD44. (Q44357503)

2 December 2017

title

Presenilin-dependent gamma-secretase activity mediates the intramembranous cleavage of CD44. (English)

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Bart De Strooper

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2 December 2017

Daizo Murakami

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Isamu Okamoto

2

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2 December 2017

Yoshiaki Kawano

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Takeshi Iwatsubo

6

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Eiji Yumoto

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Hideyuki Saya

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2 December 2017

language of work or name

English

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publication date

1 March 2003

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2 December 2017

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2 December 2017

volume

22

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issue

10

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2 December 2017

page(s)

1511-1516

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CD44 is the principal cell surface receptor for hyaluronate

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cites work

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Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein

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A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

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The hyaluronate receptor is a member of the CD44 (H-CAM) family of cell surface glycoproteins

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7 January 2021

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

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Phosphorylation, subcellular localization, and membrane orientation of the Alzheimer's disease-associated presenilins.

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New functions for the matrix metalloproteinases in cancer progression

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A portrait of Alzheimer secretases--new features and familiar faces

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Candidate .gamma.-Secretases in the Generation of the Carboxyl Terminus of the Alzheimer's Disease .beta.A4 Amyloid: Possible Involvement of Cathepsin D

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7 January 2021

A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells

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Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

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7 January 2021

Calcium influx triggers the sequential proteolysis of extracellular and cytoplasmic domains of E-cadherin, leading to loss of beta-catenin from cell-cell contacts

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7 January 2021

Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane

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7 January 2021

Ras oncoprotein induces CD44 cleavage through phosphoinositide 3-OH kinase and the rho family of small G proteins

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7 January 2021

Presenilin-dependent gamma-secretase-like intramembrane cleavage of ErbB4.

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7 January 2021

Candidate gene for the chromosome 1 familial Alzheimer's disease locus

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7 January 2021

Proteolytic processing of low density lipoprotein receptor-related protein mediates regulated release of its intracellular domain

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7 January 2021

gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase

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7 January 2021

Regulated CD44 cleavage under the control of protein kinase C, calcium influx, and the Rho family of small G proteins.

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7 January 2021

Proteolytic release of CD44 intracellular domain and its role in the CD44 signaling pathway

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7 January 2021

CD44 cleavage induced by a membrane-associated metalloprotease plays a critical role in tumor cell migration

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7 January 2021

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

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7 January 2021

Inhibition of beta-catenin-mediated transactivation by cadherin derivatives

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7 January 2021

Presenilin-1 and -2 are molecular targets for gamma-secretase inhibitors

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7 January 2021

L-685,458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid beta-protein precursor gamma-secretase activity

1 reference

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7 January 2021

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

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7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1206298

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2 December 2017

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