The EGL-21 carboxypeptidase E facilitates acetylcholine release at Caenorhabditis elegans neuromuscular junctions. (Q44376549)

PubMed publication ID

12657671

2 December 2017

title

The EGL-21 carboxypeptidase E facilitates acetylcholine release at Caenorhabditis elegans neuromuscular junctions (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6742027&resulttype=core&format=json

12 May 2020

main subject

Caenorhabditis elegans

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neuropeptide processing

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Gene Ontology release 2020-05-02

Gene Ontology ID

GO:0061837

Carboxypeptidase E CELE_F01D4.4

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Acetylcholine receptor subunit beta-type unc-29 CELE_T08G11.5

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Kinesin-like protein unc-104 CELE_C52E12.2

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Neuroendocrine convertase 2 CELE_C51E3.7

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neuromuscular junction

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Tija C Jacob

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6742027&resulttype=core&format=json

12 May 2020

Joshua M Kaplan

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6742027&resulttype=core&format=json

12 May 2020

language of work or name

English

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publication date

1 March 2003

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PubMed publication ID

12657671

2 December 2017

published in

Journal of Neuroscience

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6742027&resulttype=core&format=json

12 May 2020

volume

23

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6742027&resulttype=core&format=json

12 May 2020

issue

6

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6742027&resulttype=core&format=json

12 May 2020

page(s)

2122-2130

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The neuroendocrine protein 7B2 is required for peptide hormone processing in vivo and provides a novel mechanism for pituitary Cushing's disease

12 May 2020

cites work

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12 December 2020

The complete family of genes encoding G proteins of Caenorhabditis elegans

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12 December 2020

Glu300 of rat carboxypeptidase E is essential for enzymatic activity but not substrate binding or routing to the regulated secretory pathway

1 reference

12 December 2020

A role for amontillado, the Drosophila homolog of the neuropeptide precursor processing protease PC2, in triggering hatching behavior.

1 reference

12 December 2020

Visualization of synaptic specializations in live C. elegans with synaptic vesicle protein-GFP fusions

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12 December 2020

Goalpha and diacylglycerol kinase negatively regulate the Gqalpha pathway in C. elegans

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12 December 2020

Facilitation of synaptic transmission by EGL-30 Gqalpha and EGL-8 PLCbeta: DAG binding to UNC-13 is required to stimulate acetylcholine release

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12 December 2020

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12 December 2020

A pdf neuropeptide gene mutation and ablation of PDF neurons each cause severe abnormalities of behavioral circadian rhythms in Drosophila

1 reference

12 December 2020

Neuropeptide gene families in the nematode Caenorhabditis elegans

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12 December 2020

Serotonin inhibition of synaptic transmission: Galpha(0) decreases the abundance of UNC-13 at release sites.

1 reference

12 December 2020

A look at the Caenorhabditis elegans Kex2/Subtilisin-like proprotein convertase family

1 reference

12 December 2020

Molecular cloning and characterization of a new insulin/IGF-like peptide of the nematode Caenorhabditis elegans

1 reference

12 December 2020

PHM is required for normal developmental transitions and for biosynthesis of secretory peptides in Drosophila

1 reference

12 December 2020

Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family

1 reference

12 December 2020

Attenuated processing of proglucagon and glucagon-like peptide-1 in carboxypeptidase E-deficient mice

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12 December 2020

Identification of peptides from brain and pituitary of Cpe(fat)/Cpe(fat) mice

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12 December 2020

Drosophila CAPS is an essential gene that regulates dense-core vesicle release and synaptic vesicle fusion

1 reference

12 December 2020

Multiple amidated neuropeptides are required for normal circadian locomotor rhythms in Drosophila.

1 reference

12 December 2020

Isolation and preliminary biological assessment of AADGAPLIRFamide and SVPGVLRFamide from Caenorhabditis elegans

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12 December 2020

The EGL-3 proprotein convertase regulates mechanosensory responses of Caenorhabditis elegans.

1 reference

12 December 2020

Identification of neuropeptide-like protein gene families in Caenorhabditiselegans and other species

1 reference

12 December 2020

Regulation of the pharynx of Caenorhabditis elegans by 5-HT, octopamine, and FMRFamide-like neuropeptides

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12 December 2020

Regulation of retrograde signaling at neuromuscular junctions by the novel C2 domain protein AEX-1.

1 reference

12 December 2020

Egg-laying defective mutants of the nematode Caenorhabditis elegans

1 reference

12 December 2020

Functional characterization of the adenylyl cyclase gene sgs-1 by analysis of a mutational spectrum in Caenorhabditis elegans.

1 reference

12 December 2020

Ubiquitin and AP180 regulate the abundance of GLR-1 glutamate receptors at postsynaptic elements in C. elegans

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12 December 2020

Localization of FMRFamide-like peptides in Caenorhabditis elegans

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12 December 2020

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12 December 2020

Mutations in the bli-4 (I) locus of Caenorhabditis elegans disrupt both adult cuticle and early larval development

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12 December 2020

Two soluble forms of bovine carboxypeptidase H have different NH2-terminal sequences

1 reference

12 December 2020

Identification of the pH-dependent membrane anchor of carboxypeptidase E (EC 3.4.17.10).

1 reference

12 December 2020

Human carboxypeptidase E. Isolation and characterization of the cDNA, sequence conservation, expression and processing in vitro

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12 December 2020

Organogenesis in C. elegans: positioning of neurons and muscles in the egg-laying system

1 reference

12 December 2020

The action of FMRFamide (Phe-Met-Arg-Phe-NH2) and related peptides on mammals

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12 December 2020

Distribution and partial characterization of FMRFamide-like peptides in the stomatogastric nervous systems of the rock crab, Cancer borealis, and the spiny lobster, Panulirus interruptus

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12 December 2020

The genetics of Caenorhabditis elegans

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12 December 2020

Caenorhabditis elegans mutants resistant to inhibitors of acetylcholinesterase

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12 December 2020

The silver gene of Drosophila melanogaster encodes multiple carboxypeptidases similar to mammalian prohormone-processing enzymes

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12 December 2020

Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity

1 reference

12 December 2020

A neuropeptide gene defined by the Drosophila memory mutant amnesiac

1 reference

12 December 2020

The bli-4 locus of Caenorhabditis elegans encodes structurally distinct kex2/subtilisin-like endoproteases essential for early development and adult morphology

1 reference

12 December 2020

Modulation of serotonin-controlled behaviors by Go in Caenorhabditis elegans

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12 December 2020

Participation of the protein Go in multiple aspects of behavior in C. elegans

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12 December 2020

Synaptic function is impaired but not eliminated in C. elegans mutants lacking synaptotagmin

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12 December 2020

The C-terminal region of carboxypeptidase E involved in membrane binding is distinct from the region involved with intracellular routing

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12 December 2020

Mutations in a C. elegans Gqalpha gene disrupt movement, egg laying, and viability.

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12 December 2020

Impaired processing of brain proneurotensin and promelanin-concentrating hormone in obese fat/fat mice

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12 December 2020

A genetic selection for Caenorhabditis elegans synaptic transmission mutants

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12 December 2020

Carboxypeptidase E activity is deficient in mice with the fat mutation. Effect on peptide processing

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12 December 2020

APEASPFIRFamide, a novel FMRFamide-related decapeptide from Caenorhabditis elegans: structure and myoactivity

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12 December 2020

Effect of carboxypeptidase E deficiency on progastrin processing and gastrin messenger ribonucleic acid expression in mice with the fat mutation

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12 December 2020

The pro region is not required for the expression or intracellular routeing of carboxypeptidase E

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12 December 2020

Defective prohormone processing and altered pancreatic islet morphology in mice lacking active SPC2.

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12 December 2020

An activating mutation in a Caenorhabditis elegans Gs protein induces neural degeneration

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12 December 2020

Cholecystokinin (CCK) levels are greatly reduced in the brains but not the duodenums of Cpe(fat)/Cpe(fat) mice: a regional difference in the involvement of carboxypeptidase E (Cpe) in pro-CCK processing

1 reference

12 December 2020

Caenorhabditis elegans rab-3 mutant synapses exhibit impaired function and are partially depleted of vesicles.

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12 December 2020

Disturbed progastrin processing in carboxypeptidase E-deficient fat mice

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12 December 2020

Inhibitory effects of nematode FMRFamide-related peptides (FaRPs) on muscle strips from Ascaris suum

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12 December 2020

The G alpha protein ODR-3 mediates olfactory and nociceptive function and controls cilium morphogenesis in C. elegans olfactory neurons.

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12 December 2020

G alphas-induced neurodegeneration in Caenorhabditis elegans.

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12 December 2020

Defect in synaptic vesicle precursor transport and neuronal cell death in KIF1A motor protein-deficient mice.

1 reference

12 December 2020

New insulin-like proteins with atypical disulfide bond pattern characterized in Caenorhabditis elegans by comparative sequence analysis and homology modeling.

1 reference

12 December 2020

Ethanol intoxication in Drosophila: Genetic and pharmacological evidence for regulation by the cAMP signaling pathway

1 reference

12 December 2020

KSAYMRFamide (PF3/AF8) is present in the free-living nematode, Caenorhabditis elegans.

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12 December 2020

Differential regulation of exocytosis by calcium and CAPS in semi-intact synaptosomes.

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12 December 2020

Cloning and developmental regulation of a novel member of the insulin-like gene family in Caenorhabditis elegans

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12 December 2020

G protein hyperactivation of the Caenorhabditis elegans adenylyl cyclase SGS-1 induces neuronal degeneration

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12 December 2020

Disruption of a neuropeptide gene, flp-1, causes multiple behavioral defects in Caenorhabditis elegans

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12 December 2020

Functional redundancy of FMRFamide-related peptides at the Drosophila larval neuromuscular junction

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12 December 2020

Natural variation in a neuropeptide Y receptor homolog modifies social behavior and food response in C. elegans

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12 December 2020

Altered processing of procholecystokinin in carboxypeptidase E-deficient fat mice: differential synthesis in neurons and endocrine cells.

1 reference

12 December 2020

Neurobiology of the Caenorhabditis elegans genome.

1 reference

12 December 2020

Isolation, pharmacology and gene organization of KPSFVRFamide: a neuropeptide from Caenorhabditis elegans

1 reference

12 December 2020

10.1523/JNEUROSCI.23-06-02122.2003

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6742027&resulttype=core&format=json

12 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6742027&resulttype=core&format=json

12 May 2020

PubMed publication ID

12657671

1 reference