Comprehensive analysis of gene expression in rat and human hepatoma cells exposed to the peroxisome proliferator WY14,643 (Q44428695)

2 December 2017

Comprehensive analysis of gene expression in rat and human hepatoma cells exposed to the peroxisome proliferator WY14,643 (English)

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30 December 2023

main subject

hepatocellular carcinoma

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1 reference

https://api.crossref.org/works/10.1016/S0041-008X(03)00015-2

30 December 2023

author name string

Dirk Kreder

2

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2 December 2017

Benjamin Belda

3

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2 December 2017

John P. Vanden Heuvel

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12729718

30 December 2023

Daniel B. Hannon

4

1 reference

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30 December 2023

Courtney A. Nugent

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12729718

30 December 2023

Katherine A. Burns

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12729718

30 December 2023

Michael J. Taylor

7

1 reference

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30 December 2023

language of work or name

English

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National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12729718

30 December 2023

publication date

1 May 2003

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full work available at URL

2 December 2017

https://api.elsevier.com/content/article/PII:S0041008X03000152?httpAccept=text/xml

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https://api.crossref.org/works/10.1016/S0041-008X(03)00015-2

https://api.elsevier.com/content/article/PII:S0041008X03000152?httpAccept=text/plain

30 December 2023

1 reference

https://api.crossref.org/works/10.1016/S0041-008X(03)00015-2

Toxicology and Applied Pharmacology

30 December 2023

published in

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2 December 2017

188

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2 December 2017

3

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2 December 2017

185-198

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Transcriptional activation by peroxisome proliferator-activated receptor gamma is inhibited by phosphorylation at a consensus mitogen-activated protein kinase site

2 December 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900015-2

7 January 2021

Suppression of liver cell apoptosis in vitro by the non-genotoxic hepatocarcinogen and peroxisome proliferator nafenopin

1 reference

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7 January 2021

Wy-14,643 stimulates hepatic protein kinase C activity

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900015-2

7 January 2021

Insulin regulates MAP kinase phosphatase-1 induction in Hirc B cells via activation of both extracellular signal-regulated kinase (ERK) and c-Jun-N-terminal kinase (JNK).

1 reference

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7 January 2021

Regulation of peroxisome proliferator-activated receptor gamma activity by mitogen-activated protein kinase

1 reference

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7 January 2021

Do peroxisome proliferating compounds pose a hepatocarcinogenic hazard to humans?

1 reference

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7 January 2021

Identification of novel peroxisome proliferator-activated receptor alpha (PPARalpha) target genes in mouse liver using cDNA microarray analysis

1 reference

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7 January 2021

Perplexing peroxisome proliferators

1 reference

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7 January 2021

Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900015-2

7 January 2021

Conditional expression of the mitogen-activated protein kinase (MAPK) phosphatase MKP-1 preferentially inhibits p38 MAPK and stress-activated protein kinase in U937 cells

1 reference

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7 January 2021

A Truncated Human Peroxisome Proliferator-Activated Receptor Splice Variant with Dominant Negative Activity

1 reference

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7 January 2021

Inhibition of monocyte and macrophage chemotaxis by hypoxia and inflammation--a potential mechanism

1 reference

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7 January 2021

Resistance to TNF-alpha cytotoxicity can be achieved through different signaling pathways in rat mesangial cells.

1 reference

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7 January 2021

Gene expression analysis reveals chemical-specific profiles

1 reference

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7 January 2021

Downregulation of lactoferrin by PPARalpha ligands: role in perturbation of hepatocyte proliferation and apoptosis

1 reference

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7 January 2021

Map kinase phosphatases (MKP's) are early responsive genes during induction of cerulein hyperstimulation pancreatitis

1 reference

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7 January 2021

Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators

1 reference

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7 January 2021

Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase

1 reference

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7 January 2021

The peroxisome proliferator-activated receptor alpha regulates amino acid metabolism.

1 reference

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7 January 2021

Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha and gamma

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900015-2

7 January 2021

Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors

1 reference

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7 January 2021

mkp-1 encoding mitogen-activated protein kinase phosphatase 1, a verotoxin 1 responsive gene, detected by differential display reverse transcription-PCR in Caco-2 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900015-2

7 January 2021

Mitogen-activated protein kinase phosphatase-1 (MKP-1) expression is induced by low oxygen conditions found in solid tumor microenvironments. A candidate MKP for the inactivation of hypoxia-inducible stress-activated protein kinase/c-Jun N-terminal

1 reference

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7 January 2021

Cycloheximide-induced cPLA2 activation is via the MKP-1 down-regulation and ERK activation

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900015-2

7 January 2021

Biochemical mechanisms of induction of hepatic peroxisome proliferation

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900015-2

7 January 2021

Diverse peroxisome proliferator-activated receptors bind to the peroxisome proliferator-responsive elements of the rat hydratase/dehydrogenase and fatty acyl-CoA oxidase genes but differentially induce expression

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900015-2

7 January 2021

Independent regulation of JNK/p38 mitogen-activated protein kinases by metabolic oxidative stress in the liver

1 reference

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7 January 2021

Induction of mitogen-activated protein kinase phosphatase-1 by arachidonic acid in vascular smooth muscle cells

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900015-2

7 January 2021

Peroxisome proliferation and nongenotoxic carcinogenesis: commentary on a symposium

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900015-2

7 January 2021

A protein histidine kinase induced in rat liver by peroxisome proliferators. In vitro activation by Ras protein and guanine nucleotides

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900015-2

7 January 2021

Protein phosphorylation by peroxisome proliferators: species-specific stimulation of protein kinases and its role in PP-induced transcriptional activation

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900015-2

7 January 2021

Evidence for direct binding of fatty acids and eicosanoids to human peroxisome proliferators-activated receptor alpha

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900015-2

7 January 2021

Microarrays and toxicology: the advent of toxicogenomics

1 reference

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7 January 2021

Ciprofibrate, a carcinogenic peroxisome proliferator, increases the phosphorylation of epidermal-growth-factor receptor in isolated rat hepatocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900015-2

7 January 2021

Peroxisome proliferator activated receptor-alpha expression in human liver.

1 reference

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7 January 2021

Human HepG2 and rat Fao hepatic-derived cell lines show different responses to ciprofibrate, a peroxisome proliferator: analysis by flow cytometry

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900015-2

7 January 2021

Influence of peroxisome proliferators on phosphoprotein levels in human and rat hepatic-derived cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900015-2

7 January 2021

Role of PPAR alpha in the mechanism of action of the nongenotoxic carcinogen and peroxisome proliferator Wy-14,643.

1 reference

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7 January 2021

Apoptosis and proliferation in nongenotoxic carcinogenesis: species differences and role of PPARalpha

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7 January 2021

Application of DNA arrays to toxicology

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7 January 2021

Revolution through genomics in investigative and discovery toxicology

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7 January 2021

Peroxisome proliferators activate extracellular signal-regulated kinases in immortalized mouse liver cells

1 reference

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7 January 2021

MAP kinase phosphatase-1 gene transcription in rat neuroendocrine cells is modulated by a calcium-sensitive block to elongation in the first exon

1 reference

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7 January 2021

Androgen-independent induction of prostate-specific antigen gene expression via cross-talk between the androgen receptor and protein kinase A signal transduction pathways

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7 January 2021

Microarrays: biotechnology's discovery platform for functional genomics.

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7 January 2021

Glucagon-induced expression of the MAP kinase phosphatase MKP-1 in rat hepatocytes

1 reference

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7 January 2021

Hypoxia-induced regulation of MAPK phosphatase-1 as identified by subtractive suppression hybridization and cDNA microarray analysis

1 reference

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7 January 2021

The peroxisome proliferator-activated receptor alpha is a phosphoprotein: regulation by insulin

1 reference

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7 January 2021

Distinct binding determinants for ERK2/p38alpha and JNK map kinases mediate catalytic activation and substrate selectivity of map kinase phosphatase-1

1 reference

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7 January 2021

Regulation of peroxisome proliferator-activated receptor-alpha mRNA in rat liver

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7 January 2021

Regulatory implications of peroxisome proliferation: an industrial perspective

1 reference

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7 January 2021

MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo

1 reference

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7 January 2021

The mouse peroxisome proliferator activated receptor recognizes a response element in the 5' flanking sequence of the rat acyl CoA oxidase gene

1 reference

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7 January 2021

Protein kinase C epsilon is required for the induction of mitogen-activated protein kinase phosphatase-1 in lipopolysaccharide-stimulated macrophages

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7 January 2021

Peroxisome proliferator-activated receptors (PPARS) and carcinogenesis

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7 January 2021

Peroxisome proliferator-activated receptors: a critical link among fatty acids, gene expression and carcinogenesis

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7 January 2021

Identification of a novel peroxisome proliferator responsive cDNA isolated from rat hepatocytes as the zinc-finger protein ZFP-37

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7 January 2021

Chemical carcinogen mechanisms of action and implications for testing methodology

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7 January 2021

Effect of a peroxisome proliferator on 3 beta-hydroxysteroid dehydrogenase

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7 January 2021

Microarray analysis of gene expression changes in mouse liver induced by peroxisome proliferator- activated receptor alpha agonists

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7 January 2021

Insulin- and mitogen-activated protein kinase-mediated phosphorylation and activation of peroxisome proliferator-activated receptor gamma

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7 January 2021

Identification of a peroxisome proliferator-responsive element upstream of the gene encoding rat peroxisomal enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase

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7 January 2021

Cross-talk between janus kinase-signal transducer and activator of transcription (JAK-STAT) and peroxisome proliferator-activated receptor-alpha (PPARalpha) signaling pathways. Growth hormone inhibition of pparalpha transcriptional activity mediated

1 reference

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7 January 2021

STAT5b Down-regulates Peroxisome Proliferator-activated Receptor α Transcription by Inhibition of Ligand-independent Activation Function Region-1trans-Activation Domain

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7 January 2021

MKP-1 as a target for pharmacological manipulations in PC12 cell survival

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7 January 2021

Insulin-mediated cell proliferation and survival involve inhibition of c-Jun N-terminal kinases through a phosphatidylinositol 3-kinase- and mitogen-activated protein kinase phosphatase-1-dependent pathway

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30 December 2023

peroxisome proliferators

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Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxisome proliferator-activated receptors by coactivator-dependent receptor ligand assay

30 December 2023

28

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Insulin-induced mitogen-activated protein (MAP) kinase phosphatase-1 (MKP-1) attenuates insulin-stimulated MAP kinase activity: a mechanism for the feedback inhibition of insulin signaling

30 December 2023

29

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Activation of peroxisome proliferator-activated receptors (PPARs) by their ligands and protein kinase A activators

30 December 2023

31

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Adrenocorticotropic hormone regulates the activities of the orphan nuclear receptor Nur77 through modulation of phosphorylation

30 December 2023

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30 December 2023

Identifiers

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2 December 2017

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